Gilead throws its weight — and $50M cash — be­hind Tan­go's I/O dis­cov­ery en­gine

Gilead is in for the long game in im­muno-on­col­o­gy. And that has spelled a big break for a small Third Rock start­up boast­ing a CRISPR-pow­ered dis­cov­ery en­gine.

Tan­go Ther­a­peu­tics has scored a “sig­nif­i­cant” col­lab­o­ra­tion with the big biotech that starts with $50 mil­lion up­front and dons a string of fees and mile­stones that could add up to $1.7 bil­lion.

No­tably, though, Tan­go is hold­ing on­to an op­tion to co-de­vel­op and co-com­mer­cial­ize two of the five pro­grams that could emerge from the pact. That’s in line with its vi­sion to even­tu­al­ly be­come a ful­ly in­te­grat­ed biotech — not a CRO — even though its lead pro­grams are still in very pre­lim­i­nary stages of pre­clin­i­cal de­vel­op­ment, CEO Bar­bara We­ber tells me.

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