Grail vet Ba­jaj aims for some broad in­flu­ence with Fore­site bucks

Biotech has lost an­oth­er top ex­ec­u­tive to the al­lure of fi­nance. Vikram Ba­jaj, just one year in­to his job as chief sci­en­tif­ic of­fi­cer at Grail, has joined the ranks of Sil­i­con Val­ley VCs.

Vikram Ba­jaj

Ba­jaj is tak­ing a full-time gig as man­ag­ing di­rec­tor of SF-based Fore­site Cap­i­tal, a VC and pri­vate eq­ui­ty firm where Ba­jaj hopes to have a big­ger im­pact mov­ing sci­ence for­ward. Fore­site closed a $450 mil­lion fund back in 2015, and ap­pears to still be mak­ing in­vest­ments from that pool. With $1.2 bil­lion in as­sets un­der man­age­ment, Fore­site has made bets on a few big names in­clud­ing Juno, Nan­tK­west, and Grail, Ba­jaj’s for­mer em­ploy­er.

Grail is a high-fly­ing start­up try­ing to make a test that de­tects can­cer ear­ly. Oth­er than its am­bi­tious goals, Grail is prob­a­bly best known for rais­ing $1 bil­lion in un­der two years. It’s al­so known for its c-suite of ex-Googlers (al­though many are now mov­ing on).

But work­ing at a whizbang start­up ap­pears to have on­ly whet­ted Ba­jaj’s ap­petite for in­no­va­tion. He tells me en­ter­ing the VC world is ex­cit­ing be­cause ac­cess to mon­ey means he’ll have a wider im­pact.

“It puts me in a unique po­si­tion to have in­flu­ence in a va­ri­ety of ar­eas, not just one com­pa­ny, but across dif­fer­ent seg­ments of our in­dus­try,” Ba­jaj said.

He’s par­tic­u­lar­ly in­ter­est­ed in the com­pa­nies that com­bine da­ta sci­ence and hu­man bi­ol­o­gy, which is sort of his do­main. On top of be­ing the co-founder of Ver­i­ly (for­mer­ly Google Life Sci­ences), Ba­jaj al­so led lab­o­ra­to­ry and da­ta sci­ence teams at Grail. And as a for­mer aca­d­e­m­ic re­searcher, Ba­jaj and his col­lab­o­ra­tors have de­vel­oped nan­otech and oth­er tools that were lat­er com­mer­cial­ized by star­tups.

Ba­jaj said per­son­al­ized med­i­cine — with the help of da­ta sci­ence — is on­ly get­ting start­ed. He thinks it’s a good time to en­ter this space as an in­vestor, with cash to move the right tech­nolo­gies for­ward.

“I think we’re poised for mas­sive change as se­quenc­ing costs go down and med­i­cine be­comes more pre­cise as a re­sult of this ex­plo­sion of da­ta,” Ba­jaj said.

Fore­site plans to tap his knowl­edge of the space to spot promis­ing star­tups to in­vest in.

“I’ve known of Vik years through his pre­vi­ous roles,” Fore­site’s CEO Jim Tanan­baum tells me. “His ex­per­tise in the field and team-ori­ent­ed and hum­ble ap­proach to his work makes him an ex­cel­lent ad­di­tion to our high­ly col­lab­o­ra­tive team here at Fore­site Cap­i­tal. He brings a unique mix of skills and ex­pe­ri­ence that will be par­tic­u­lar­ly help­ful as we ex­pand on our in­vest­ments in pre­ci­sion med­i­cine.”

Ba­jaj said Fore­site’s stage-ag­nos­tic in­vest­ment strat­e­gy was re­fresh­ing, and a ma­jor rea­son he want­ed to join the firm.

“There are no ar­bi­trary bar­ri­ers to in­vest­ing at a par­tic­u­lar stage,” Ba­jaj said. “We can in­vest any­where from the seed stage through to pub­lic liq­uid­i­ty and be­yond. I like this ap­proach be­cause health care star­tups are dif­fer­ent from oth­er tech­nol­o­gy star­tups: the time hori­zon is longer, the prob­lems more com­plex, and the reg­u­la­to­ry en­vi­ron­ment more chal­leng­ing to nav­i­gate.”

Ba­jaj will be sta­tioned at the com­pa­ny’s SF of­fice in the Transamer­i­ca Pyra­mid.

Paul Hudson, Getty Images

Sanofi CEO Hud­son lays out new R&D fo­cus — chop­ping di­a­betes, car­dio and slash­ing $2B-plus costs in sur­gi­cal dis­sec­tion

Earlier on Monday, new Sanofi CEO Paul Hudson baited the hook on his upcoming strategy presentation Tuesday with a tell-tale deal to buy Synthorx for $2.5 billion. That fits squarely with hints that he’s pointing the company to a bigger future in oncology, which also squares with a major industry tilt.

In a big reveal later in the day, though, Hudson offered a slate of stunners on his plans to surgically dissect and reassemble the portfoloio, saying that the company is dropping cardio and diabetes research — which covers two of its biggest franchise arenas. Sanofi missed the boat on developing new diabetes drugs, and now it’s pulling out entirely. As part of the pullback, it’s dropping efpeglenatide, their once-weekly GLP-1 injection for diabetes.

“To be out of cardiovascular and diabetes is not easy for a company like ours with an incredibly proud history,” Hudson said on a call with reporters, according to the Wall Street Journal. “As tough a choice as that is, we’re making that choice.”

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.

Amarin CEO John Thero discussing the company's plans for Vascepa, August 2019 — via Bloomberg

Amarin wins a block­buster ap­proval from the FDA. Now every­one can shift fo­cus to the patent

For all those people who could never quite believe that Amarin $AMRN would get an expanded label with blockbuster implications, the stress and anxiety on display right up to the last minute on Twitter can now end. But new, pressing questions will immediately surface now that the OK has come through.

On Friday afternoon, the FDA stamped its landmark approval on the industrial strength fish oil for reducing cardio risks for a large and well defined population of patients. The approval doesn’t give Amarin everything it wants in expanding its use, losing out on the primary prevention group, but it goes a long way to doing what the company needed to make a major splash. The approval was cited for patients with “elevated triglyceride levels (a type of fat in the blood) of 150 milligrams per deciliter or higher. Patients must also have either established cardiovascular disease or diabetes and two or more additional risk factors for cardiovascular disease.”

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.

Sarep­ta was stunned by the re­jec­tion of Vyondys 53. Now it's stun­ning every­one with a sur­prise ac­cel­er­at­ed ap­proval

Sarepta has a friend in the FDA after all. Four months after the agency determined that it would be wrong to give Sarepta an accelerated approval for their Duchenne MD drug golodirsen, regulators have executed a stunning about face and offered the biotech a quick green light in any case.

It was the agency that first put out the news late Thursday, announcing that Duchenne MD patients with a mutation amenable to exon 53 skipping will now have their first targeted treatment: Vyondys 53, or golodirsen. Having secured the OK via a dispute resolution mechanism, the biotech said the new drug has been priced on par with their only other marketed drug, Exondys 51 — which for an average patient costs about $300,000 per year, but since pricing is based on weight, that sticker price can even cross $1 million.

Sarepta shares $SRPT surged 23% after-market to $124.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.

Paul Biondi (File photo)

Paul Biondi's track record at Bris­tol-My­ers cov­ered bil­lions in deals of every shape and size. Here's the com­plete break­down

Paul Biondi was never afraid to bet big during his stint as business development chief at Bristol-Myers Squibb. And while the gambles didn’t all pay out, by any means, his roster of pacts illustrates the broad ambitions the pharma giant has had over the last 5 years — capped by the $74 billion Celgene buyout.

On Thursday, we learned that Biondi had exited the company. And Chris Dokomajilar at DealForma came up with the complete breakdown on every buyout, licensing pact and product purchase Bristol-Myers forged during his tenure in charge of the BD team at one of the busiest companies in biopharma.

Endpoints Premium

Premium subscription required

Unlock this article along with other benefits by subscribing to one of our paid plans.

Paul Biondi (File photo)

Bris­tol-My­er­s' strat­e­gy, BD chief Paul Bion­di ex­it­ed the com­pa­ny — just ahead of the $74B Cel­gene deal close

Paul Biondi, who orchestrated billions of dollars in deals for Bristol-Myers Squibb over the 5 years he’s run their business development team, has exited the company. Biondi left last month, according to a company spokesperson, in pursuit of another — unspecified — external opportunity.

After 17 years with Bristol-Myers Squibb, Paul Biondi, Head of Strategy and Business Development, decided to leave the company to pursue an external opportunity. The company wishes him well in his new endeavors. Bristol-Myers Squibb  is actively searching for Paul’s successor, and will make an announcement, as appropriate.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.

Arie Belldegrun at UKBIO 2019. Shai Dolev for Endpoints News

Kite Phar­ma's ex-CEO con­tra­dicts founder as CAR-T patent tri­al heats up, with con­flict­ing val­u­a­tions

Two days after Kite Pharma founder Arie Belldegrun told a federal courtroom that a meeting he had with a Memorial Sloan Kettering executive wasn’t about licensing their immunotherapy patent, Kite’s ex-CEO Aya Jakobovits said it was.

The admission came Tuesday during cross-examination in a patent infringement case that features two of the biggest cancer biotechs and some of the most well-known names in American medicine.

Jakobovits initially said she was not in attendance, didn’t know it was going to happen and didn’t know what took place, according to Law360. But then the plaintiff’s lawyer handed her a document – whose contents were not publicly revealed – and asked again if she learned after-the-fact that the meeting involved a potential patent license.

“Yes,” Jakobovits eventually said.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.

On the heels of promis­ing MCL da­ta, Kite hus­tles its 2nd CAR-T to the FDA as the next big race in the field draws to the fin­ish line

Three days after Gilead’s Kite subsidiary showed off stellar data on their number 2 CAR-T KTE-X19 at ASH, the executive team has pivoted straight to the FDA with a BLA filing and a shot at a near-term approval.

In a small, 74-patient Phase II trial reported out at the beginning of the week, investigators tracked a 93% response rate with two out of three mantle cell lymphoma patients experiencing a complete response.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.

What does $6.9B buy these days in on­col­o­gy R&D? As­traZeneca has a land­mark an­swer

Given the way the FDA has been whisking through new drug approvals months ahead of their PDUFA date, AstraZeneca and their partners Daiichi Sankyo may not have to wait until Q2 of next year to get a green light on trastuzumab deruxtecan (DS-8201).

The pharma giant this morning played their ace in the hole, showing off why they were willing to commit to a $6.9 billion deal — with $1.35 billion in a cash upfront — to partner on the drug.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.

Arie Belldegrun (Photo: Jeff Rumans for Endpoints News)

Ju­ry finds Gilead li­able for $585M and big roy­al­ties in Kite CAR-T patent case

A Kite deal that’s already become a burden on Gilead’s back just got heavier as a California jury has ruled Gilead must pay Bristol-Myers Squibb and Sloan Kettering $585 million plus a 27.6% royalty for patent infringement committed by its subsidiary. The ruling is almost certain to be appealed.

Kite Pharma — founded by Arie Belldegrun, now focused on a next-gen CAR-T company — has been facing a lawsuit since the day its first CAR–T therapy won approval in October, 2017. Juno Therapeutics and Sloan Kettering filed a complaint saying Kite had copied its technology. Gilead acquired Kite in June of that year for $11.9 billion.  Juno was acquired the following year by Celgene for $9 billion, before Celgene was acquired by Bristol-Myers Squibb in 2019.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 67,600+ biopharma pros reading Endpoints daily — and it's free.