Charles Lieber (Charles Krupa, AP)

Har­vard's Charles Lieber in­dict­ed for ly­ing to the feds, bring­ing US re­searcher­s' Chi­na ties back to the spot­light

Five months af­ter his shock­ing ar­rest, Charles Lieber has been in­dict­ed by a fed­er­al grand ju­ry for ly­ing to au­thor­i­ties about his in­volve­ment in Chi­na’s Thou­sand Tal­ents Pro­gram.

The 61-year-old sci­en­tist — who chaired Har­vard’s chem­istry de­part­ment and led a lab spe­cial­iz­ing in nanoscience be­fore he was ar­rest­ed and placed on ad­min­is­tra­tive leave in late Jan­u­ary — is fac­ing two counts of mak­ing false state­ments. He will be ar­raigned in fed­er­al court at a lat­er date, and is ex­pect­ed to con­test the charges.

While Lieber was not the first Amer­i­can sci­en­tist not of Chi­nese eth­nic­i­ty to be swept up in the FBI’s probe in­to aca­d­e­m­ic es­pi­onage, his case stood out be­cause of his high pro­file and the sever­i­ty of the po­ten­tial con­se­quences. From a DOJ re­lease:

The charge of mak­ing false state­ments pro­vides for a sen­tence of up to five years in prison, three years of su­per­vised re­lease and a fine of $250,000.

Amid some re­newed ten­sion in US-Chi­na re­la­tions — with Pres­i­dent Don­ald Trump point­ing fin­gers at Chi­na’s ini­tial han­dling of the coro­n­avirus out­break, and Xi Jin­ping es­sen­tial­ly dar­ing the US by im­pos­ing a na­tion­al se­cu­ri­ty law on Hong Kong — Amer­i­can of­fi­cials are said to be con­sid­er­ing fur­ther re­stric­tions on the en­try of Chi­nese stu­dents as re­tal­i­a­tion. The re­ports sparked new de­bates around the Trump ad­min­is­tra­tion’s ac­cu­sa­tions that Chi­na has been steal­ing sci­en­tif­ic se­crets by in­fil­trat­ing top or­ga­ni­za­tions. With­in the bio­med­ical en­ter­prise, aca­d­e­m­ic es­pi­onage is an ac­knowl­edged prob­lem, al­though sci­en­tists are di­vid­ed on what counts as spy­ing, how per­va­sive it is and whether the gov­ern­ment is throw­ing out the ba­by with the bath wa­ter.

As an in­ter­nal in­ves­ti­ga­tion by the Mof­fitt Can­cer Cen­ter high­light­ed, col­lab­o­rat­ing with or even re­ceiv­ing funds from Chi­nese uni­ver­si­ties aren’t an of­fense in the gov­ern­ment and re­search in­sti­tu­tions’ eyes. It on­ly be­comes an is­sue when re­searchers hide their af­fil­i­a­tion — time com­mit­ment as well as pay­ments — even when no se­crets are ap­par­ent­ly di­vulged.

At Mof­fitt, the fail­ure to re­port cost six top of­fi­cials their job, in­clud­ing its for­mer CEO and ac­claimed hema­tol­o­gist Alan List.

Lieber’s ties to Chi­na al­leged­ly be­gan in 2011 when he, “un­be­knownst to Har­vard Uni­ver­si­ty,” be­came a strate­gic sci­en­tist at Wuhan Uni­ver­si­ty of Tech­nol­o­gy. For the next three years, he would sign on­to the Thou­sand Tal­ents Plan, which is de­signed to re­cruit top brains like him­self.

Un­der that con­tract, the DOJ said he was paid a salary of $50,000 per month, liv­ing ex­pens­es of up to ap­prox­i­mate­ly $158,000 USD, and award­ed more than $1.5 mil­lion to es­tab­lish a re­search lab at the uni­ver­si­ty. In re­turn, he al­leged­ly agreed to no less than nine months of work per year.

All of that came in on top of the $15 mil­lion in grants Lieber has re­ceived from the NIH over the years.

But when the feds came knock­ing in April 2018, he told in­ves­ti­ga­tors that he was nev­er asked to par­tic­i­pate in Thou­sand Tal­ents, ac­cord­ing to the com­plaint. Har­vard, al­leged­ly tak­ing him by his word, al­so told the NIH he had no for­mal as­so­ci­a­tion with WUT af­ter 2012 and that the Wuhan in­sti­tu­tion was false­ly ex­ag­ger­at­ing his role there.

His lawyer, Marc Mukasey, told the Har­vard Crim­son that the gov­ern­ment has it wrong, and that Lieber is the vic­tim, not the per­pe­tra­tor.

“Pro­fes­sor Lieber has ded­i­cat­ed his life to sci­ence and to his stu­dents,” Mukasey wrote. “Not mon­ey, not fame, just his sci­ence and his stu­dents. […] “When jus­tice is done, Char­lie’s good name will be re­stored and the sci­en­tif­ic com­mu­ni­ty again will be able to ben­e­fit from his in­tel­lect and pas­sion.”

A new era of treat­ment: How bio­mark­ers are chang­ing the way we think about can­cer

AJ Patel was recovering from a complicated brain surgery when his oncologist burst into the hospital room yelling, “I’ve got some really great news for you!”

For two years, Patel had been going from doctor to doctor trying to diagnose his wheezing, only to be dealt the devastating news that he had stage IV lung cancer and only six months to live. And then they found the brain tumors.

“What are you talking about?” Patel asked. He had never seen an oncologist so happy.

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ProFound Therapeutics founding team

Flag­ship's lat­est biotech could turn some of the thou­sands of new pro­teins it dis­cov­ered in­to ther­a­pies — and it has $75M to start

Flagship Pioneering, the incubator of Moderna and dozens of other biotechs, says it has landed upon tens of thousands of previously undiscovered human proteins. The VC shop wants to potentially turn them into therapeutics.

Like other drug developers that have turned proteins into therapeutics (think insulin for diabetes), Flagship’s latest creation, ProFound Therapeutics, wants to tap into this new trove of proteins as part of its mission to treat indications ranging from rare diseases to cancer to immunological diseases.

Richard Silverman, Akava Therapeutics founder and Northwestern professor

This time around, Lyri­ca's in­ven­tor is de­vel­op­ing his North­west­ern dis­cov­er­ies at his own biotech

Richard Silverman was left in the dark for the last five years of clinical development of the drug he discovered. The Northwestern University professor found out about the first approval of Lyrica, in the last few days of 2004, like most other people: in the newspaper.

What became one of Pfizer’s top-selling meds, at $5 billion in 2017 global sales before losing patent protection in 2019, started slipping out of his hands when Northwestern licensed it out to Parke-Davis, one of two biotechs that showed interest in developing the drug in the pre-email days, when the university’s two-person tech transfer team had to ship out letters to garner industry appetite.

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Robert Califf (Michael Brochstein/Sipa USA via AP Images)

House Re­pub­li­cans at­tack Chi­na-on­ly da­ta in FDA sub­mis­sions, seek new in­ves­ti­ga­tion in­to re­search in­spec­tions

Three Republican representatives are calling on the FDA to take a closer look at the applications including only clinical data from China.

The letter to FDA commissioner Rob Califf late last week comes as the agency recently rejected Eli Lilly’s anti-PD-1 antibody, which attempted to bring China-only data but ran into a bruising adcomm that may crush the hopes of any other companies looking to bring cheaper follow-ons based only on Chinese data.

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David Ricks, Eli Lilly CEO (David Paul Morris/Bloomberg via Getty Images)

Eli Lil­ly set to in­vest $2.1B in home state man­u­fac­tur­ing boost

Eli Lilly is looking to expand its footprint in its home Hoosier State by making a major investment in manufacturing.

The pharma is investing $2.1 billion in two new manufacturing sites at Indiana’s LEAP Lebanon Innovation and Research District in Boone County, northwest of Lilly’s headquarters in Indianapolis.

The two new facilities will expand Lilly’s manufacturing network for active ingredients and new therapeutic modalities, including genetic medicines, according to a press release.

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Up­dat­ed: US sees spike in Paxlovid us­age as Mer­ck­'s mol­nupi­ravir and As­traZeneca's Evusheld are slow­er off the shelf

New data from HHS show that more than 162,000 courses of Pfizer’s Covid-19 antiviral Paxlovid were administered across the US over the past week, continuing a streak of increased usage of the pill, and signaling not only rising case numbers but more awareness of how to access it.

In comparison to this week, about 670,000 courses of the Pfizer pill have been administered across the first five months since Paxlovid has been on the US market, averaging about 33,000 courses administered per week in that time.

Pfiz­er and CD­MOs ramp up Paxlovid man­u­fac­tur­ing with Kala­ma­zoo plant ex­pan­sion lead­ing the way

As the Covid-19 pandemic continues to evolve, pharma companies and manufacturers are exploring how to step up production on antivirals.

Pfizer is planning to expand its Kalamazoo-area facility to increase manufacturing capabilities for the oral Covid-19 antiviral Paxlovid, according to a report from Michigan-based news site MLive. The expansion of the facility, which serves as Pfizer’s largest manufacturing location, is expected to create hundreds of “high-skilled” STEM jobs, MLive reported. No details about the project’s cost and timeline have been released, but according to MLive, Pfizer will announce the details of the expansion at some point in early June.

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FDA spells out the rules and re­stric­tions for states seek­ing to im­port drugs from Cana­da

The FDA is offering more of an explanation of the guardrails around its program that may soon allow states to import prescription drugs in some select circumstances from Canada, but only if such imports will result in significant cost reductions for consumers.

While the agency has yet to sign off on any of the 5 state plans in the works so far, and PhRMA’s suit to block the Trump-era rule allowing such imports is stalled, the new Q&A guidance spells out the various restrictions that states will have to abide by, potentially signaling that a state approval is coming.

Pfizer CEO Albert Bourla at the World Economic Forum (Gian Ehrenzeller/Keystone via AP Images)

All about ac­cess: Pfiz­er moves to a non-prof­it mod­el for drug sales in 45 low­er-in­come coun­tries

Leading the way to increase access to cheaper drugs worldwide, Pfizer said Wednesday it will provide all current and future patent-protected medicines and vaccines available in the US or EU on a not-for-profit basis to about 1.2 billion people in 45 lower-income countries.

Rwanda, Ghana, Malawi, Senegal and Uganda are the first five countries to sign on to this accord, which will also seek to blaze new paths for quick and efficient regulatory and procurement processes to reduce the usual delays in making new medicines and vaccines available in these countries.