Thai Public Health Minister Anutin Charnvirakul (Photo by Vachira Vachira/NurPhoto via AP)

Home­grown mR­NA Thai vac­cine for Covid-19 could be ready by year end — re­port

The Thai Food and Drug Ad­min­is­tra­tion will soon re­view tri­al re­sults from its coun­try’s first lo­cal­ly-de­vel­oped Covid-19 vac­cine, which us­es the same mR­NA tech­nol­o­gy that suc­cess­ful vac­cines from Pfiz­er/BioN­Tech and Mod­er­na have al­so em­ployed. If all goes well, Thai­land will roll out its first home­grown vac­cine by the end of this year, its gov­ern­ment has said.

The first lot of the vac­cine was pro­duced by BioNet-Asia, and de­vel­oped by Chu­la­longko­rn Uni­ver­si­ty re­searchers, the Bangkok Post re­port­ed. The jab, dubbed Chu­la­Cov19, has yet to be­gin clin­i­cal tri­als in hu­mans but ex­pects to lat­er this year, the Chu­la Vac­cine Re­search Cen­ter said. The cen­ter worked in col­lab­o­ra­tion with UPenn Pro­fes­sor Drew Weiss­man, who al­so worked on the mR­NA vac­cine tech that Pfiz­er/BioN­Tech de­ployed.

The vac­cine’s pro­duc­tion was spurred by a 2.31 bil­lion baht ($67 mil­lion) in­vest­ment from the gov­ern­ment last year.

BioNet-Asia can make 20 mil­lion dos­es a year. More than a dozen vac­cines are be­ing de­vel­oped, ac­cord­ing to Bloomberg, in an ef­fort to cut back re­liance on for­eign sup­ply. Chu­la­longko­rn’s is the most ad­vanced. Thai­land is al­so home to As­traZeneca’s on­ly man­u­fac­tur­ing site in south­east Asia.

Racha­da Dhnadi­rek

Deputy gov­ern­ment spokes­woman Racha­da Dhnadi­rek told the Bangkok Post that Thai­land’s goal of pro­duc­ing its own vac­cine aligns with its 10-year strate­gic plan to be­come a med­ical hub by 2026.

“The goal was set be­fore the Covid-19 pan­dem­ic be­gan, and by be­com­ing a vac­cine pro­duc­tion cen­ter, more Thai peo­ple will have ac­cess to the vac­cine,” she told the out­let.

Last Ju­ly, As­traZeneca ran in­to vac­cine dis­tri­b­u­tion is­sues in Thai­land and was forced to ask the gov­ern­ment for a five-month ex­ten­sion of the time­line to de­liv­er 61 mil­lion dos­es, bring­ing its dead­line all the way to this May. The hic­cup led Thai­land to re­port­ed­ly con­sid­er im­pos­ing ex­port bans on lo­cal­ly pro­duced dos­es of the jab, as waves of the virus hit its pop­u­la­tion hard.

Two weeks ago, the Quad Vac­cine Part­ner­ship hand­ed over a con­sign­ment of Cov­di-19 vac­cines from In­dia to the gov­ern­ment of Thai­land. More than 200,000 made-in-In­dia dos­es of Cov­o­vax were giv­en to the Min­is­ter of Pub­lic Health Anutin Charn­vi­rakul on April 21 in Bangkok.

A new era of treat­ment: How bio­mark­ers are chang­ing the way we think about can­cer

AJ Patel was recovering from a complicated brain surgery when his oncologist burst into the hospital room yelling, “I’ve got some really great news for you!”

For two years, Patel had been going from doctor to doctor trying to diagnose his wheezing, only to be dealt the devastating news that he had stage IV lung cancer and only six months to live. And then they found the brain tumors.

“What are you talking about?” Patel asked. He had never seen an oncologist so happy.

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Cracks in the fa­cade: Is phar­ma's pan­dem­ic ‘feel good fac­tor’ wan­ing?

The discordant effects of the Covid-19 pandemic on pharma reputation continues. While the overall industry still retains a respectable halo from its Covid-19 quick response and leadership, a new patient group study reveals a different story emerging in the details.

On one hand, US patient advocacy groups rated the industry higher-than-ever overall. More than two-thirds (67%) of groups gave the industry a thumbs up for 2021, a whopping 10 percentage point increase over the year before, according to the PatientView annual study, now in its 9th year.

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Belén Garijo, Merck KGaA CEO (Kevin Wolf/AP Images for EMD Serono)

Mer­ck KGaA pumps €440M in­to ex­pand­ing and con­struct­ing Irish man­u­fac­tur­ing fa­cil­i­ties

The area of Ireland famous for Blarney Castle and its cliffsides along the Atlantic Ocean is seeing Merck KGaA expand its commitment there.

The German drug manufacturer is expanding its membrane and filtration manufacturing capabilities in Ireland. The company will invest approximately €440 million ($470 million) to increase membrane manufacturing capacity in Carrigtwohill, Ireland, and build a new manufacturing facility at Blarney Business Park, in County Cork, Ireland.

Phillip Gomez, SIGA CEO

UP­DAT­ED: On the back of SIGA Tech­nolo­gies' win with the FDA, the mon­key­pox virus sees the com­pa­ny spring­ing to fur­ther ac­tion

As the cases of monkeypox now sit at well over 100 worldwide and have spread to multiple continents, the orders for any type of vaccine against monkeypox are seeing nations and medical bodies looking to get their hands on anything and everything. And now SIGA Technologies seems to be getting in on the action.

According to Euronews, SIGA Technologies, a pharmaceutical company that is focused on providing medical countermeasures to biological and chemical attacks, is now in talks with several European authorities looking to stockpile its antiviral that can counter monkeypox. The drug known as tecovirimat or Tpoxx was approved by the FDA in 2018 as a vaccine for smallpox but was approved by the European Medicines Agency to also act against monkeypox, cowpox and complications from immunization with vaccinia.

Co­pay coupons gone wrong, again: Pfiz­er pays al­most $300K to set­tle com­plaints in four states

Pfizer has agreed to pay $290,000 to settle allegations of questionable copay coupon practices in Arizona, Colorado, Kansas, and Vermont from 2014 to 2018.

While the company has not admitted any wrongdoing as part of the settlement, Pfizer has agreed to issue restitution checks to about 5,000 consumers.

A Pfizer spokesperson said the company has “enhanced its co-pay coupons to alleviate the concerns raised by states and agreed to a $30,000 payment to each.”

Delaware court rules against Gilead and Astel­las in years-long patent case

A judge in Delaware has ruled against Astellas Pharma and Gilead in a long-running patent case over Pfizer-onwed Hospira’s generic version of Lexiscan.

The case kicked off in 2018, after Hospira submitted an Abbreviated New Drug Application (ANDA) for approval to market a generic version of Gilead’s Lexiscan. The drug is used in myocardial perfusion imaging (MPI), a type of nuclear stress test.

Taye Diggs (courtesy Idorsia)

Idor­sia inks an­oth­er celebri­ty en­dors­er deal with ac­tor and dad Taye Dig­gs as Qu­viviq in­som­nia am­bas­sador

Idorsia’s latest Quviviq insomnia campaign details the relatable dad story of a well-known celebrity — actor and Broadway star Taye Diggs.

Diggs stopped sleeping well after the birth of his son, now more than 10 years ago. Switching mom-and-dad nightly shifts to take care of a baby interrupted his sleep patterns and led to insomnia.

“When you’re lucky enough to be living out your dream and doing what you want, but because of something as simple as a lack of sleep, you’re unable to do that, it felt absolutely — it was treacherous,” he says in an interview-style video on the Quviviq website.

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Rep. Katie Porter (D-CA) (Michael Brochstein/Sipa USA/Sipa via AP Images)

House Dems to Sen­ate lead­er­ship: Quick­ly move a rec­on­cil­i­a­tion bill with drug price ne­go­ti­a­tion re­forms

Twenty House Democrats, including Reps. Katie Porter of California and Susan Wild of Pennsylvania, are calling on Senate leaders to move quickly with a reconciliation bill (meaning they only need a simple majority for passage) with prescription drug pricing reforms, and to include adding new authority for Medicare to negotiate drug prices.

They also called on the Senate to specifically follow suit with the House passage of a $35 per month insulin cap (as Senate Majority Leader Chuck Schumer’s deadline for a vote on that provision has come and gone), and to cap Medicare Part D costs at $2,000 per year for seniors.

Bris­tol My­ers Squibb sues No­var­tis for roy­al­ties sur­round­ing the use of trans­genic mice

Two Big Pharma companies are going to the mat over genetically modified mice in a licensing dispute.

Bristol Myers Squibb is suing Novartis in New York over a dispute concerning an evaluation, research and commercialization agreement stretching back to the late ’90s initially inked between Novartis and BMS’ predecessor Medarex. The deal in question allowed Novartis to use Medarex’s patented transgenic mice to develop therapeutic drugs. Novartis agreed to pay Medarex – and subsequently BMS – a royalty on sales of drugs it developed using the mice.