In a pioneering first, AstraZeneca scores FDA OK to use its PARP against breast cancer
AstraZeneca $AZN has picked up another key win for its cancer drug franchise.
The FDA approved its PARP inhibitor Lynparza for BRCA-mutated metastatic breast cancer, offering the pharma giant a path forward to expand its use beyond ovarian cancer. And this is a first in the field.
Their Phase III data made the showcase round at ASCO last summer and is further enhancing the FDA’s focus on drugs that can target cancers triggered by the same genetic causes. The drug was linked with tumor shrinkage in 60% of the patients with germline BRCA1 or BRCA2 mutations taking the drug, compared to 29% in the chemo group. And the OK gives them an edge over their rivals: Clovis’ Rubraca and Tesaro’s Zejula.
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