In ‘clever’ ex­per­i­ment, sci­en­tists use gene edit­ing to treat heart dis­ease in mice

Re­searchers are al­ready us­ing gene edit­ing to tack­le rare in­her­it­ed dis­eases. But in a new pa­per, re­searchers use that tool in mice to treat the lead­ing cause of death in the world: heart dis­ease.

In a study pub­lished in Sci­ence Thurs­day, Er­ic Ol­son, Si­mon Lebek and col­leagues from UT South­west­ern mod­i­fied a gene in mice that en­codes an en­zyme that, when chron­i­cal­ly over­ac­tive, can lead to an ar­ray of heart dis­eases. The en­zyme, known as CaMKI­I𝛿, reg­u­lates heart func­tion, and is one form of CaMKII, which plays im­por­tant reg­u­la­to­ry roles in many or­gans in the body.

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