In ‘clever’ experiment, scientists use gene editing to treat heart disease in mice
Researchers are already using gene editing to tackle rare inherited diseases. But in a new paper, researchers use that tool in mice to treat the leading cause of death in the world: heart disease.
In a study published in Science Thursday, Eric Olson, Simon Lebek and colleagues from UT Southwestern modified a gene in mice that encodes an enzyme that, when chronically overactive, can lead to an array of heart diseases. The enzyme, known as CaMKII𝛿, regulates heart function, and is one form of CaMKII, which plays important regulatory roles in many organs in the body.
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