In the foot­steps of As­traZeneca, No­var­tis com­mits to car­bon-neu­tral sup­ply chain by 2030

Fol­low­ing in As­traZeneca’s car­bon-re­duced foot­steps, No­var­tis an­nounced new sus­tain­abil­i­ty tar­gets on Tues­day, which in­clude plans to neu­tral­ize sup­ply chain emis­sions in the next 10 years.

The Swiss phar­ma aims to be car­bon-neu­tral in its own op­er­a­tions by 2025, and across its sup­ply chain by 2030. To get there, it says it will re­duce ab­solute emis­sions by 35% across its val­ue chain, and fol­low a “dual strat­e­gy” to de­crease en­er­gy and fu­el con­sump­tion, im­prove ef­fi­cien­cy and adopt re­new­able en­er­gy sources. It au­dit­ed all ma­jor sites for po­ten­tial im­prove­ments.

“We have a long­stand­ing, com­pre­hen­sive en­er­gy and cli­mate pro­gram, which aims to im­prove en­er­gy ef­fi­cien­cy for all in­dus­tri­al and com­mer­cial op­er­a­tions and use re­new­able en­er­gy sources where avail­able and fea­si­ble,” the com­pa­ny stat­ed.

No­var­tis tout­ed what it’s al­ready do­ing to pre­serve the en­vi­ron­ment, in­clud­ing se­ques­ter­ing car­bon through forestry projects in Colom­bia, Mali, Chi­na and Ar­genti­na. It plant­ed 800 hectares of trees at the San­to Domin­go Es­tate in Ar­genti­na in 2007, then added 2,250 hectares in the fol­low­ing three years. By 2040, the com­pa­ny ex­pects to col­lect up to 2 mil­lion tons of car­bon diox­ide equiv­a­lents through the project. It al­so boast­ed of its Texas wind farm, and says it has sim­i­lar plans to achieve green en­er­gy in Eu­rope.

“Af­ter the suc­cess­ful com­ple­tion of a re­new­able pow­er pur­chase agree­ment in the US that achieved car­bon neu­tral­i­ty in that mar­ket for pro­cured elec­tric­i­ty we are now ac­tive­ly pur­su­ing a pan-Eu­ro­pean pow­er pur­chase agree­ment that will achieve the same, de­car­boniz­ing our pur­chased elec­tric­i­ty in one of our largest re­gions of op­er­a­tions and elim­i­nat­ing tran­si­tion risk as­so­ci­at­ed with car­bon pric­ing,” No­var­tis’ CDP cli­mate change in­for­ma­tion re­quest states.

The an­nounce­ment comes about 7 months af­ter UK-based As­traZeneca com­mit­ted to achiev­ing neg­a­tive car­bon emis­sions across its val­ue chain by 2030. The com­pa­ny will in­vest up to $1 bil­lion in its “Am­bi­tion Ze­ro Car­bon” strat­e­gy, which in­cludes us­ing re­new­able en­er­gy for pow­er and heat, and switch­ing to a 100% elec­tric ve­hi­cle fleet five years ahead of sched­ule.

“Cli­mate change is an ur­gent threat to pub­lic health, the en­vi­ron­ment and the sus­tain­abil­i­ty of the glob­al econ­o­my. Since 2015, we have re­duced our car­bon emis­sions from op­er­a­tions by al­most a third and our wa­ter con­sump­tion by al­most one fifth,” As­traZeneca CEO Pas­cal So­ri­ot said in a state­ment.

Pfiz­er lays off em­ploy­ees at Cal­i­for­nia and Con­necti­cut sites

Pfizer has laid off employees at its La Jolla, CA, and Groton, CT sites, according to multiple LinkedIn posts from former employees.

The Big Pharma confirmed to Endpoints News it has let go of some employees, but a spokesperson declined to specify how many workers were impacted and the exact locations affected. Earlier this month, the drug developer had confirmed to Endpoints it was sharpening its focus and doing away with some early research on areas such as rare disease, oncology and gene therapies.

Endpoints Premium

Premium subscription required

Unlock this article along with other benefits by subscribing to one of our paid plans.

Late Fri­day ap­proval; Trio of biotechs wind down; Stem cell pi­o­neer finds new fron­tier; Biotech icon to re­tire; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

I hope your weekend is off to a nice start, wherever you are reading this email. As for me, I’m trying to catch the tail of the Lunar New Year festivities.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 157,500+ biopharma pros reading Endpoints daily — and it's free.

Jake Van Naarden, Loxo@Lilly CEO

Lil­ly en­ters ripe BTK field with quick FDA nod in man­tle cell lym­phoma

Eli Lilly has succeeded in its attempt to get the first non-covalent version of Bruton’s tyrosine kinase, or BTK, inhibitors to market, pushing it past rival Merck.

The FDA gave an accelerated nod to Lilly’s daily oral med, to be sold as Jaypirca, for patients with relapsed or refractory mantle cell lymphoma.

The agency’s green light, disclosed by the Indianapolis Big Pharma on Friday afternoon, catapults Lilly into a field dominated by covalent BTK inhibitors, which includes AbbVie and Johnson & Johnson’s Imbruvica, AstraZeneca’s Calquence and BeiGene’s Brukinsa.

Filip Dubovsky, Novavax CMO

No­vavax gets ready to take an­oth­er shot at Covid vac­cine mar­ket with next sea­son plans

While mRNA took center stage at yesterday’s FDA vaccine advisory committee meeting, Novavax announced its plans to deliver an updated protein-based vaccine based on new guidance.

Vaccines and Related Biological Products Advisory Committee (VRBPAC) members voted unanimously in favor of “harmonizing” Covid vaccine compositions, meaning all future vaccine recipients would receive a bivalent vaccine, regardless of whether they’ve gotten their primary series.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 157,500+ biopharma pros reading Endpoints daily — and it's free.

CBER Director Peter Marks (Susan Walsh/AP Images)

FDA ad­vi­so­ry com­mit­tee votes unan­i­mous­ly in fa­vor of bi­va­lent Covid shots re­plac­ing pri­ma­ry se­ries

The FDA’s Vaccines and Related Biological Products Advisory Committee (VRBPAC) voted unanimously in favor of “harmonizing” Covid vaccine compositions, meaning all current vaccine recipients would receive a bivalent vaccine, regardless of whether they’ve gotten their primary series.

The vote marks an effort to clear up confusion around varying formulations and dosing schedules for current primary series and booster vaccines, as well as “get closer to the strains that are circulating,” according to committee member Paul Offit, professor of pediatrics at the Children’s Hospital of Philadelphia.

Rodney Rietze, iVexSol CEO

Bris­tol My­ers, Charles Riv­er join Se­ries A fund­ing for iVex­Sol

Massachusetts-based iVexSol has secured funding to the tune of $23.8 million in its latest Series A round. The new investors include Bristol Myers Squibb, manufacturer Charles River Laboratories and Asahi Kasei Medical.

iVexSol is a manufacturer of lentiviral vectors (LVV), used in making gene therapies, and this latest round of fundraising brings its total Series A total over $39 million, which will be used to recruit more employees and bolster its technology.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 157,500+ biopharma pros reading Endpoints daily — and it's free.

John Rim, Samsung Biologics CEO (Samsung/PR Newswire)

Sam­sung Bi­o­log­ics spells out ex­pan­sion plans in South Ko­rea and US

The CDMO arm of one of South Korea’s largest conglomerates has posted its year-end results and plans for 2023, which include new construction.

Samsung Biologics netted north of KRW 3 trillion ($2.4 billion) in 2022 revenue and an operating profit of KRW 983.6 billion ($799 million), which the company touted on Friday as “record-high earnings.” The revenue boost was 55% compared to 2021.

No­var­tis' ap­proved sick­le cell dis­ease drug fails to beat place­bo in PhI­II

Novartis’ sickle cell drug, approved in 2019 and branded as Adakveo, has failed an ongoing Phase III, according to preliminary results.

The Swiss pharma giant unveiled early data from the ongoing STAND Phase III study on Friday, saying that crizanlizumab showed no statistically significant difference between the drug at two different dose levels compared to placebo in annualized rates of vaso-occlusive crises that lead to a healthcare visit over the first year since being randomized into the trial.

Sen. Elizabeth Warren (D-MA) (Michael Brochstein/Sipa USA/Sipa via AP Images)

Sen. Eliz­a­beth War­ren urges FTC to 'scru­ti­nize' two phar­ma buy­outs

Sen. Elizabeth Warren (D-MA) is calling on senior Federal Trade Commission officials to “closely scrutinize” two proposed pharma mergers.

Warren expressed concern over “rampant consolidation in the pharmaceutical industry,” in particular Amgen’s $28 billion plans to take over Horizon Therapeutics, and Indivior’s proposed acquisition of Opiant for $145 million upfront, in a letter to FTC Chair Lina Khan and Commissioners Alvaro Bedoya and Rebecca Kelly Slaughter earlier this week.