Ionis touts PhII MASH study data that feature its DGAT2 antisense inhibitor
Ionis said on Wednesday that its metabolic dysfunction-associated steatohepatitis (MASH) drug hit the primary and secondary endpoints of a Phase II trial, notably showing histologic improvement and MASH resolution.
The drug, a DGAT2 antisense inhibitor dubbed ION224, was tested at 120 mg and 90 mg in 160 patients across 49 weeks. Ionis used the NAFLD Activity Score to measure liver histologic improvement.
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