It’s fi­nal­ly over: Bio­gen, Ei­sai scrap big Alzheimer’s PhI­I­Is af­ter a pre­dictable BACE cat­a­stro­phe rais­es safe­ty fears

Months af­ter an­a­lysts and in­vestors called on Bio­gen and Ei­sai to scrap their BACE drug for Alzheimer’s and move on in the wake of a string of late-stage fail­ures and ris­ing safe­ty fears, the part­ners have called it quits. And they said they were drop­ping the drug — elen­be­ce­s­tat — af­ter the in­de­pen­dent mon­i­tor­ing board raised con­cerns about…safe­ty.

We don’t know ex­act­ly what re­searchers found in this lat­est cat­a­stro­phe, but the com­pa­nies not­ed in their re­lease that in­ves­ti­ga­tors had de­ter­mined that the drug was flunk­ing the risk/ben­e­fit analy­sis.

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