Peter Nell, Mammoth Biosciences CBO

Jen­nifer Doud­na spin­out inks a Mam­moth CRISPR deal with Ver­tex worth near­ly $700M

When a com­pa­ny gets its start in gene edit­ing pi­o­neer Jen­nifer Doud­na’s lab, it’s bound to make head­lines. But three years in, the fan­fare still hasn’t died down for Mam­moth Bio­sciences. Now, the Bris­bane, CA-based com­pa­ny is cheer­ing on its first ma­jor R&D pact.

Mam­moth un­veiled a near­ly $700 mil­lion deal with Ver­tex on Tues­day morn­ing, good for the de­vel­op­ment of in vi­vo gene ther­a­pies for two mys­tery dis­eases. The stars of the show are Mam­moth’s ul­tra-small CRISPR sys­tems, in­clud­ing two Cas en­zymes li­censed from Doud­na’s lab over the past cou­ple years, Cas14 and Casɸ.

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