J&J's Rybrevant-chemo combo shows positive PFS data in confirmatory study
Johnson & Johnson’s Rybrevant met its primary endpoint in a Phase III confirmatory study testing the drug on patients with newly diagnosed advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations, the company said in a topline data release Monday.
J&J compared a combo of chemotherapy and Rybrevant, which was the first drug approved for patients with the mutation, with just chemotherapy in the PAPILLON study. The combo showed a “statistically significant and clinically meaningful improvement” in progression-free survival, the company said.
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