Juno gets some badly needed relief after a glimpse of upbeat early data on JCAR017
Anxious to turn the page on a deadly series of cerebral edema cases, Juno Therapeutics today turned to an upbeat set of preliminary data for JCAR017, which may soon emerge as its top drug in the pipeline.
Twelve of 20 patients who could be evaluated for efficacy in the study of CD19-positive cases of non-Hodgkin lymphoma demonstrated a complete response to the CAR-T therapy following treatment at dose level 1 (5×107 cells). There was some evidence of durability, with 42% of the patients (8/19) with diffuse large B-cell lymphoma treated more than three months before the data cutoff experiencing an ongoing response. And there were no cases of severe cytokine release syndrome with grade 3-4 neurotoxicity seen in three individuals among 22 in the dose level 1 group who were evaluable for safety.
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