Lat­est rank­ing of top re­search in­sti­tu­tions show Chi­na com­ing on strong — with sig­nif­i­cant im­pli­ca­tions for biotech

As Chi­na’s biotech in­dus­try en­joys ex­plod­ing growth, there’s fresh ev­i­dence that the coun­try’s sci­en­tif­ic elite is muscling up the lad­der of pres­ti­gious in­sti­tu­tions around the world.

Na­ture as­sem­bled its close­ly-watched an­nu­al in­dex of re­search cen­ters around the world, and Chi­na con­tin­ues to hold the top spot, along with an over­all sec­ond-place fin­ish on aca­d­e­m­ic in­sti­tu­tions — be­hind the US.

Here’s the list of the top 15 in­sti­tu­tions over­all — based on counts of high-qual­i­ty re­search out­puts in the pre­vi­ous cal­en­dar year — along with a link to the full 500 they tracked this year. 

The Chi­nese Acad­e­my of Sci­ences made the top spot again this year, while Chi­na’s Peking Uni­ver­si­ty and Ts­inghua Uni­ver­si­ty scored in the top 15 aca­d­e­m­ic re­search in­sti­tu­tions. And Xin­hua made care­ful note that Nan­jing Uni­ver­si­ty along with the Uni­ver­si­ty of Sci­ence and Tech­nol­o­gy of Chi­na have jumped ahead from last year in­to the top ranks. 

To be sure, US aca­d­e­m­ic in­sti­tu­tions have re­tained their grip on the top places in acad­e­mia. Har­vard, Stan­ford, MIT, and Berke­ley dom­i­nate the top 5, with the Uni­ver­si­ty of Tokyo fill­ing the last spot there. 

Chi­na, though, now has 16 of the top 100 glob­al aca­d­e­m­ic cen­ters on this list, com­pared to 11 in 2016.

So what’s the big deal?

The first wave of Chi­nese biotechs we’ve been see­ing are large­ly in-li­cens­ing ap­proved and late-stage drugs from US part­ners. The busi­ness mod­el seems sound. Raise mon­ey, hus­tle up de­vel­op­ment of a known com­mod­i­ty with clear ideas on tri­al out­lines. Big out­fits like Mer­ck and As­traZeneca have al­so been en­joy­ing a shake­up of the coun­try’s reg­u­la­to­ry group, mak­ing strides in open­ing new mar­kets. There’s been one ap­proval of a drug in­vent­ed in Chi­na that I know about as de­vel­op­ers every­where fo­cus on fill­ing the drug gap be­tween the US and Chi­na.

But as the sci­ence gets bet­ter and the pipeline sifts through the first wave of drugs, you’ll start to see more orig­i­nal drug de­vel­op­ment work, which has been miss­ing. Things are chang­ing fast in Chi­na bio­phar­ma, and not just be­cause of the fi­nanc­ing that’s avail­able.

More change is straight ahead.

Im­age: Chi­nese Acad­e­my of Sci­ences HQ Cre­ative Com­mons

Health­care Dis­par­i­ties and Sick­le Cell Dis­ease

In the complicated U.S. healthcare system, navigating a serious illness such as cancer or heart disease can be remarkably challenging for patients and caregivers. When that illness is classified as a rare disease, those challenges can become even more acute. And when that rare disease occurs in a population that experiences health disparities, such as people with sickle cell disease (SCD) who are primarily Black and Latino, challenges can become almost insurmountable.

The End­points 11: They've got mad mon­ey and huge am­bi­tions. It's time to go big or go home

These days, selecting a group of private biotechs for the Endpoints 11 spotlight begins with a sprint to get ahead of IPOs and the M&A teams at Big Pharma. I’ve had a couple of faceplants earlier this year, watching some of the biotechs on my short list choose a quick leap onto Nasdaq or into the arms of a buyer.

Vividion, you would have been a great pick for the Endpoints 11. I’m sorry I missed you.

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Dave Lennon, former president of Novartis Gene Therapies

So what hap­pened with No­var­tis Gene Ther­a­pies? Here's your an­swer

Over the last couple of days it’s become clear that the gene therapy division at Novartis has quietly undergone a major reorganization. We learned on Monday that Dave Lennon, who had pursued a high-profile role as president of the unit with 1,500 people, had left the pharma giant to take over as CEO of a startup.

Like a lot of the majors, Novartis is an open highway for head hunters, or anyone looking to staff a startup. So that was news but not completely unexpected.

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Jacob Van Naarden (Eli Lilly)

Ex­clu­sives: Eli Lil­ly out to crash the megablock­buster PD-(L)1 par­ty with 'dis­rup­tive' pric­ing; re­veals can­cer biotech buy­out

It’s taken 7 years, but Eli Lilly is promising to finally start hammering the small and affluent PD-(L)1 club with a “disruptive” pricing strategy for their checkpoint therapy allied with China’s Innovent.

Lilly in-licensed global rights to sintilimab a year ago, building on the China alliance they have with Innovent. That cost the pharma giant $200 million in cash upfront, which they plan to capitalize on now with a long-awaited plan to bust up the high-price market in lung cancer and other cancers that have created a market worth tens of billions of dollars.

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Who are the women su­per­charg­ing bio­phar­ma R&D? Nom­i­nate them for this year's spe­cial re­port

The biotech industry has faced repeated calls to diversify its workforce — and in the last year, those calls got a lot louder. Though women account for just under half of all biotech employees around the world, they occupy very few places in C-suites, and even fewer make it to the helm.

Some companies are listening, according to a recent BIO survey which showed that this year’s companies were 2.5 times more likely to have a diversity and inclusion program compared to last year’s sample. But we still have a long way to go. Women represent just 31% of biotech executives, BIO reported. And those numbers are even more stark for women of color.

FDA+ roundup: Bs­U­FA III ready for show­time, court tells FDA to re-work com­pound­ing plan, new guid­ance up­dates and more

The FDA has now spelled out what exactly will be included in the third iteration of Biosimilar User Fee Act (BsUFA) from 2023 through 2027, which similarly to the prescription drug deal, sets fees that industry has to pay for submitting applications, in exchange for firm timelines that the agency must meet.

This latest deal includes several sweeteners for the biosimilar industry, which has yet to make great strides in the US market, with shorter review timelines for safety labeling updates and updates to add or remove an indication that does not contain efficacy data.

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Joshua Liang, Clover Biopharmaceuticals CEO

With world still in sore need of dos­es, Clover says its Covid-19 vac­cine is 67% ef­fec­tive in Phase III

With concerns about the Delta variant rising and much of the world still in desperate need of vaccine doses, a Chinese biotech announced Wednesday that a new shot has shown positive results in a large trial against Covid-19, including new variants.

Clover Biopharmaceuticals announced Wednesday that its vaccine candidate showed 79% efficacy against the Delta variant in a Phase II/III trial dubbed Spectra, and 67% effective against Covid-19 overall.

Jean Bennett (Brent N. Clarke/Invision/AP Images)

Lux­tur­na in­ven­tor Jean Ben­nett starts a new gene ther­a­py com­pa­ny to tack­le rare dis­eases left be­hind by phar­ma, VCs

A few years ago Jean Bennett found herself in a surprising place for a woman who invented the first gene therapy ever approved in the United States: No one, it seemed, wanted her work.

Bennett, who designed and co-developed Luxturna, approved in 2018 for a rare form of blindness, had kept building new gene therapies for eye diseases at her University of Pennsylvania lab. But although the results in animals looked promising, pharma companies and investors kept turning down the pedigreed ophthalmology professor.

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Maureen Hillenmeyer, Hexagon Bio CEO

Hexa­gon Bio rais­es $61M to con­tin­ue ef­forts to turn fun­gi in­to drugs

A year after raising a $47 million launch round, the fungi-loving drug hunters at Hexagon Bio have more than doubled their coffers.

Hexagon announced today that it raised another $61 million for its efforts to design cancer and infectious disease drugs based on insights mined from the DNA in millions of species of fungi. The new financing brings Hexagon’s committed funding to over $108 million.