Le­vo Ther­a­peu­tics miss­es pri­ma­ry end­point in PhI­II tri­al of Prad­er-Willi drug — the lat­est set­back in a dis­as­ter-prone field

Mark­ing yet an­oth­er set­back in the Prad­er-Willi Syn­drome field, Le­vo Ther­a­peu­tics failed to hit its pri­ma­ry end­point in a Phase III study of in­tranasal car­be­tocin. But the biotech is now shift­ing its fo­cus to the sec­ondary end­points in an ef­fort to pluck vic­to­ry out of the jaws of de­feat.

The dis­or­der, char­ac­ter­ized by a false sense of star­va­tion, is caused by the ab­sence or dele­tion of a fa­ther’s chro­mo­some 15. Illi­nois-based Le­vo’s po­ten­tial ther­a­py in­volves a se­lec­tive oxy­tocin-re­cep­tor ag­o­nist.

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