Little Alder bags positive PhIII migraine data, but giant rivals are racing ahead in a crowded field
Little Alder BioPharmaceuticals $ALDR has racked up a slate of positive late-stage data for its Phase III study of a new CGRP migraine drug, but it will likely have trouble standing out from some of the giant players that are already out front in the race to regulators.
Dubbed PROMISE 1, investigators established a baseline average of 8.6 monthly migraines in its group of frequent episodic migraine sufferers. Alder’s quarterly-dosed 300 mg and 100 mg cut that rate by 4.3 and 3.9 days. But the placebo arm also experienced a hefty 3.2 day improvement, leaving the biotech with a statistically significant but unremarkable hit on the primary endpoint.
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