Charles Ban­croft makes quick leap from Bris­tol My­ers ex­ec team to GSK; Medicxi adds two new part­ners to its team

Charles Ban­croft

→ Just a few days af­ter Bris­tol My­ers re­port­ed that Charles Ban­croft had “re­tired” from the ex­ec­u­tive team, he’s made a quick ca­reer shift to the board at Glax­o­SmithK­line. GSK re­port­ed to­day that Ban­croft is tak­ing a non-ex­ec­u­tive di­rec­tor post at the gi­ant phar­ma out­fit. He’s slat­ed to chair GSK’s au­dit & risk com­mit­tee. Ban­croft has ex­ten­sive com­mer­cial and strat­e­gy ex­pe­ri­ence in the busi­ness.

Eu­ro­pean in­vest­ment firm Medicxi has tapped San­ford (Sandy) Zweifach and Paul Sekhri as ven­ture part­ners. Zweifach is cur­rent­ly chair­man of Pal­la­dio Bio­sciences and ex­ec­u­tive chair­man of Jan­pix — both port­fo­lio com­pa­nies of Medicxi. Pre­vi­ous­ly, Zweifach was the CEO and co-founder of Nu­ve­la­tion Phar­ma and As­cen­dan­cy Health­care. Sekhri, one of the best con­nect­ed ex­ecs in bio­phar­ma, is the pres­i­dent and CEO of eGe­n­e­sis and has pre­vi­ous­ly served as pres­i­dent and CEO of Lyc­era, as well as chief strat­e­gy of­fi­cer for Te­va Phar­ma­ceu­ti­cals In­dus­tries and CBO and pres­i­dent of ARI­AD Phar­ma­ceu­ti­cals. As End­points News re­cent­ly re­port­ed, Sekhri has al­so al­lied him­self with ex-No­var­tis CEO Joe Jimenez, who’s been rais­ing mon­ey for a new ven­ture.

Paul Sekhri, Medicxi

→ Pe­ter Linde has been named CMO at Mass­a­chu­setts-based Mor­phic Ther­a­peu­tic, a bio­phar­ma do­ing work re­volv­ing around oral in­te­grin ther­a­pies out of Tim Springer’s lab at Har­vard. Linde will over­see de­vel­op­ment of small mol­e­cule in­te­grin in­hibitors as Mor­phic ad­vances its oral in­te­grin in­hibitors to­ward clin­i­cal tri­als. Be­fore join­ing Mor­phic, Linde was at Ac­celeron as VP, med­ical re­search and Ab­b­Vie as glob­al project leader, de­vel­op­ment.

Along with open­ing an of­fice in Boston, Gaithers­burg, MD-based Sen­sei Bio­ther­a­peu­tics has named Robert Pierce as CSO. Pierce joins the com­pa­ny from the Fred Hutchin­son Can­cer Re­search Cen­ter, where he served as sci­en­tif­ic di­rec­tor of the im­munopathol­o­gy lab in the clin­i­cal re­search di­vi­sion. Pri­or to that, Pierce was CSO of On­coSec Med­ical and held a post at Mer­ck de­vel­op­ing tis­sue-based bio­mark­er ap­proach­es for Mer­ck’s Keytru­da.

Pe­ter Linde

Cy­to­Dyn, de­vel­op­ing CCR5 an­tag­o­nist leron­limab (PRO 140), has en­list­ed Ja­cob Lalezari as in­ter­im CMO. Lalezari is cur­rent­ly lead­ing the com­pa­ny’s prepa­ra­tions to ini­ti­ate a coro­n­avirus clin­i­cal tri­al. Cur­rent­ly, Lalezari is the CEO and di­rec­tor of Quest Clin­i­cal Re­search.

→ Changes abound at Leap Ther­a­peu­tics, which fo­cus­es on im­muno-on­col­o­gy, with Chris Mirabel­li step­ping down as pres­i­dent and CEO. He will be re­placed by Dou­glas On­si, who will al­so stay on as Leap’s CFO. In oth­er reshuf­fling, John Lit­tlechild has stepped down from the board of di­rec­tors, Cyn­thia Sir­ard has been pro­mot­ed to CMO and Mark O’Ma­ho­ny has been pro­mot­ed to chief man­u­fac­tur­ing of­fi­cer. Sir­ard and O’Ma­ho­ny were for­mer­ly VP, clin­i­cal R&D and VP, man­u­fac­tur­ing at Leap, re­spec­tive­ly.

→ AI biotech Re­cur­sion, which added a $121 mil­lion C round last sum­mer, has wel­comed Shafique Vi­rani as its chief cor­po­rate de­vel­op­ment of­fi­cer, serv­ing as both CBO and CEO of its new­ly-cre­at­ed De­vel­op­ment Cor­po­ra­tion. Vi­rani will lead the in­ter­nal de­vel­op­ment of Re­cur­sion’s three clin­i­cal-stage as­sets. In a ca­reer in drug de­vel­op­ment that be­gan at Roche in 2004, he most re­cent­ly was the CEO of Navire Phar­ma and CoA Ther­a­peu­tics.

Shafique Vi­rani

Sasha Damouni El­lis has been ap­point­ed VP, in­vestor re­la­tions and cor­po­rate com­mu­ni­ca­tions at Penn­syl­va­nia-based Mar­i­nus Phar­ma­ceu­ti­cals, which fo­cus­es on the de­vel­op­ment of ther­a­peu­tics to treat or­phan seizure dis­or­ders. Damouni El­lis comes to Mar­i­nus from Bay­er, where she was the phar­ma gi­ant’s US di­rec­tor of ex­ter­nal com­mu­ni­ca­tions and me­dia re­la­tions.

→ Cal­i­for­nia-based in­vest­ment man­ag­er Sofinno­va In­vest­ments has brought Jonathan Leff in­to the fold as ex­ec­u­tive part­ner. Leff’s ex­per­tise ranges from tar­get iden­ti­fi­ca­tion to FDA ap­proval and com­mer­cial­iza­tion. For­mer­ly the EVP, re­search and de­vel­op­ment at In­ter­Mune and the CMO at Kalo­Bios Phar­ma­ceu­ti­cals, Leff al­so spent time at Roche, Mer­ck and Am­gen.

→ Deal savvy Zymeworks — who has had part­ner­ships with Cel­gene, BeiGene and J&J in the past — has wel­comed Kelvin Neu to its board of di­rec­tors. Neu is a part­ner at Bak­er Bros. Ad­vi­sors.

Tesla and SpaceX founder Elon Musk gestures to the audience after being recognized by President Trump following the successful launch of a Falcon 9 rocket at the Kennedy Space Center. (via Getty Images)

Tes­la chief Elon Musk teams up with Covid-19 play­er Cure­Vac to build 'R­NA mi­cro­fac­to­ries'

Elon Musk has joined the global tech crusade now underway to revolutionize vaccine manufacturing — now aimed at delivering billions of doses of a new mRNA vaccine to fight Covid-19. And he’s cutting right to the front.

In a late-night tweet Wednesday, the Tesla chief announced:

Tesla, as a side project, is building RNA microfactories for CureVac & possibly others.

That’s not a lot to go on. But the tweet comes a year after Tesla’s German division in Grohmann and CureVac filed a patent on a “bioreactor for RNA in vitro transcription, a method for RNA in vitro transcription, a module for transcribing DNA into RNA and an automated apparatus for RNA manufacturing.” CureVac, in the meantime, has discussed a variety of plans to build microfactories that can speed up the whole process for a global supply chain.

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George Yancopoulos (Regeneron)

UP­DAT­ED: Re­gen­eron co-founder George Yan­copou­los of­fers a com­bat­ive de­fense of the po­lice at a high school com­mence­ment. It didn’t go well

Typically, the commencement speech at Yorktown Central School District in Westchester — like most high schools — is an opportunity to encourage students to face the future with confidence and hope. Regeneron president and co-founder George Yancopoulos, though, went a different route.

In a fiery speech, the outspoken billionaire defended the police against the “prejudice and bias against law enforcement” that has erupted around the country in street protests from coast to coast. And for many who attended the commencement, Yancopoulos struck the wrong note at the wrong time, especially when he combatively challenged someone for interrupting his speech with a honk for “another act of cowardness.”

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Elias Zerhouni (Photo by Vincent Isore/IP3/Getty Images)

Elias Zer­houni dis­cuss­es ‘am­a­teur hour’ in DC, the de­struc­tion of in­fec­tious dis­ease R&D and how we need to prep for the next time

Elias Zerhouni favors blunt talk, and in a recent discussion with NPR, the ex-Sanofi R&D and ex-NIH chief had some tough points to make regarding the pandemic response.

Rather than interpret them, I thought it would be best to provide snippets straight from the interview.

On the Trump administration response:

It was basically amateur hour. There is no central concept of operations for preparedness, for pandemics, period. This administration doesn’t want to or has no concept of what it takes to protect the American people and the world because it is codependent. You can’t close your borders and say, “OK, we’re going to be safe.” You’re not going to be able to do that in this world. So it’s a lack of vision, basically just a lack of understanding, of what it takes to protect the American people.

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No­vavax snags Ben Machielse for CMC and pro­motes a trio of staffers; Mar­ty Du­vall lands an­oth­er CEO post at On­copep­tides

Novavax has been making waves recently by securing a $384 million commitment from CEPI to cover R&D and manufacturing for its Covid-19 vaccine while also spending $167 million on a 150,000 square-foot facility. The Maryland biotech continues to shore up its leadership team as well, bringing in Ben Machielse as their EVP of CMC just a couple weeks after nabbing AstraZeneca vet Filip Dubrovsky as their new CMO. Machielse was president and CEO of Vtesse from 2014-17, and before that, he also spent more than 11 years at MedImmune and was EVP of operations for the back half of his tenure.

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Sec­ond death trig­gers hold on Astel­las' $3B gene ther­a­py biotech's lead pro­gram, rais­ing fresh con­cerns about AAV

Seven months after Astellas shelled out $3 billion to acquire the gene therapy player Audentes, the biotech company’s lead program has been put on hold following the death of 2 patients taking a high dose of their treatment. And there was another serious adverse event recorded in the study as well, with a total of 3 “older” patients in the study affected.

The incidents are derailing plans to file for a near-term approval, which had been expected right about now.

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Look­ing for 'ex­ter­nal in­no­va­tion,' Boehringer In­gel­heim re­serves $500M+ for new Shang­hai hub

Now that Boehringer Ingelheim’s bet on contract manufacturing in China has paid off, the German drugmaker is anteing up more to get into the research game.

Boehringer has set aside $507.9 million (€451 million) for a new External Innovation Hub to be built in Shanghai over five years. The site will become one of its “strategic pillars” as the team strives to get 71 approvals — either for new products or indications — by 2030, said Felix Gutsche, president and CEO of Boehringer Ingelheim China.

Vas Narasimhan, Novartis CEO (Patrick Straub/​EPA-EFE/​Shutterstock)

No­var­tis pays $678M for kick­back scheme as Vas Narasimhan tries to dis­tance phar­ma gi­ant from shady be­hav­ior

Novartis has reached another large settlement to resolve misconduct allegations, agreeing to pay more than $678 million to settle claims that it had spent hundreds of millions of dollars on lavish dinners, so-called speaking fees and expensive alcohol “that were nothing more than bribes” to get doctors to prescribe Novartis medications.

The top-shelf alcohol and lavish meals included a $3,250 per person night at Nobu in Dallas, a $672-per person dinner at Washington DC’s Smith & Wollensky and a $314 per person meal at Sushi Roku in Pasadena, according to the Justice Department complaint. There were at least 7 trips to Hooters and fishing trips in Alaska and off the Florida coast. Each of these events were supposed to be “speaker programs” where doctors educated other doctors on a drug, but the DOJ alleged many were “bogus” wine-and-dine events where the drug was barely mentioned, if at all.  (“Nobody presented slides on the fishing trips,” the complaint says.)

Dan Gold, MEI Pharma CEO

De­vel­op­ment part­ners at MEI, Helsinn dump a high-risk PhI­II AML study af­ter con­clud­ing it would fail sur­vival goal

Four years after Switzerland’s Helsinn put $25 million of cash on the table for an upfront and near-term milestone to take MEI Pharma’s drug pracinostat into a long-running Phase III trial for acute myeloid leukemia, the partners are walking away from a clinical pileup.

The drug — an HDAC inhibitor — failed to pass muster during a futility analysis, as researchers concluded that pracinostat combined with azacitidine wasn’t going to outperform the control group in the pivotal.

No­var­tis los­es biosim­i­lar ap­peal as court up­holds a 31-year mo­nop­oly by Am­gen's En­brel

A new court ruling has strengthened Amgen’s grip on the IP estate around Enbrel, keeping biosimilars of the autoimmune and inflammatory drug at bay until 2029.

Novartis, the patent challenger, isn’t throwing in the towel yet. In a statement noting the failed appeal, its generics division Sandoz noted its reviewing options, “including potential appeal to US Supreme Court.”

It’s been almost four years since the FDA approved Erelzi, Sandoz’s copycat version of Enbrel. While sales of the Pfizer-partnered drug in the US — the market Amgen is in charge of — have dipped slightly during that time, it remains a solid megablockbuster with 2019 revenue slightly above $5 billion.