Merck halts enrollment on two PhIII Keytruda combo studies as outside monitors flag a worrying rate of deaths
Merck $MRK has had to hit the brakes on enrolling new patients for two of its late-stage combo studies involving its blockbuster checkpoint Keytruda after the monitoring committee raised a red flag on an imbalance of deaths in the studies involving multiple myeloma.
Treatment in the two trials will continue, says Merck, as they try to evaluate why there were more deaths in the Keytruda arms of KEYNOTE-183 and KEYNOTE-185. The trials involve combinations with Celgene’s Pomalyst as well as its flagship drug Revlimid in a field Celgene dominates in.
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