Mer­ri­mack CEO, CFO bow out, months af­ter last clin­i­cal drug fiz­zles

Richard Pe­ters Mer­ri­mack

Two months ago, Mer­ri­mack was forced to aban­don its last drug in clin­i­cal tri­als, af­ter an ear­ly-stage study showed that treat­ment with the drug, MM-310, was cu­mu­la­tive­ly tox­ic to pa­tients, de­spite tri­al pro­to­col amend­ments. On Mon­day, the ex-Sanofi ex­ec­u­tive the Cam­bridge, Mass­a­chu­setts-based com­pa­ny ush­ered in 2017 to re­vive its for­tunes de­part­ed.

In 2015, Mer­ri­mack $MACK se­cured FDA ap­proval for its pan­cre­at­ic can­cer drug — Onivyde, which had a dis­ap­point­ing de­but. It was sold to Ipsen in 2017, in par­al­lel to a re­struc­tur­ing, which cul­mi­nat­ed in a new CEO — Richard Pe­ters — a slim­mer work­force and three pipeline prospects: MM-141, MM-121 and MM-310. Each of these drugs has now been rel­e­gat­ed to the scrap heap.

Jean Franchi LinkedIn

In April, af­ter ax­ing MM-310, the com­pa­ny said it was cut­ting jobs, but did not spec­i­fy how many. It now has two pre­clin­i­cal drugs — MM-401 and MM-201 — left in its ar­se­nal. Last No­vem­ber, the com­pa­ny slashed its work­force by 60%, weeks af­ter dis­clos­ing MM-121, or serib­an­tum­ab, added to do­c­etax­el made no dif­fer­ence to pa­tients with non-small cell lung can­cer. This slash and burn was pre­ced­ed by an­oth­er flop in 2018. The com­pa­ny rid it­self of MM-141 af­ter it failed a Phase II com­bo study in pan­cre­at­ic can­cer.

On Mon­day, Mer­ri­mack said Pe­ters was leav­ing the com­pa­ny. He will re­ceive $743,746.21 — 12 months of his base salary — in sev­er­ance, a pro-rat­ed bonus of $294,891.15, and the com­pa­ny will con­tin­ue pay­ing a share of the pre­mi­um for Pe­ters’ health and den­tal in­sur­ance for a pe­ri­od of one year (un­less he changes his cov­er­age). Pe­ters on June 25 agreed to con­sult with Mer­ri­mack at a rate of $30,989.43 per month to as­sist with its re­port­ing oblig­a­tions and the ad­min­is­tra­tion of re­main­ing as­sets.

Gary Crock­er Crock­er Ven­tures

Apart from Pe­ters, CFO Jean Franchi and board chair­man Gary Crock­er are al­so de­part­ing. Franchi gets $415,002.70 in sev­er­ance, a pro-rat­ed bonus of $77,544.30, a share paid for health and den­tal in­sur­ance, and con­sult­ing fees of $17,291.78 per month.

As of March 31, Mer­ri­mack had an ac­cu­mu­lat­ed deficit of $533.7 mil­lion; cash, cash equiv­a­lents and mar­ketable se­cu­ri­ties of $58.5 mil­lion; and said it ex­pects to con­tin­ue to gen­er­ate op­er­at­ing loss­es in the fore­see­able fu­ture in a fil­ing post­ed in May.

Roger Perl­mut­ter lines up deals, fresh fund­ing at Eikon; Sec­ond RSV vac­cine ap­proved; Sev­er­al biotechs flash­ing red; and more

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As you come back to our website this weekend for ASCO news, don’t forget to check out our updated event lineup at BIO, which will cover everything from the current state of VC investing in biotech to top pharma R&D chiefs discussing how to make pipeline decisions.

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Image courtesy of The Janssen Pharmaceutical Companies of Johnson & Johnson.

Pro­tect­ing the glob­al phar­ma­ceu­ti­cal in­no­va­tion ecosys­tem – what’s at stake?

We are living in a new era of healthcare that is rapidly advancing progress impacting patient outcomes and experiences. We’ve seen a remarkable pace of transformational innovation, applied research, and advanced clinical development over the last decade.

Despite this tremendous progress, there is much more work to be done, and patients are counting on us – now more than ever – to continue that momentum. At the heart of our industry is a focus on developing and delivering medicines for some of the world’s most challenging diseases, including those that have few or no effective treatments today.

Roger Perlmutter, Eikon Therapeutics CEO

Roger Perl­mut­ter builds Eikon's pipeline with deal-mak­ing flur­ry, rais­ing $106M more

Eikon Therapeutics announced three business development deals on Thursday, effectively dropping in a pipeline of cancer drugs alongside more than $100 million in fresh funding.

The Hayward, CA-based company has become one of biotech’s richest startups since its 2019 founding, having raised nearly $775 million. It’s developing a massive, automated research approach built around Nobel Prize-winning microscope science to peer inside cells and watch proteins in action. After its Series B last year, PitchBook reported a $3.02 billion valuation. And while CEO Roger Perlmutter declined to comment on that figure, he said its first tranche of nearly $106 million in Series C funding is a “meaningful step-up to our Series B valuation.”

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Stephen MacMillan, Hologic CEO (Photo by Riccardo Savi/Getty Images for Concordia Summit)

Il­lu­mi­na names Ho­log­ic CEO as new board mem­ber and chair

Illumina’s board appointed two new members, including Hologic CEO Stephen MacMillan as the non-executive chair, a move that followed a proxy fight that saw shareholders oust the company’s board chair.

The DNA sequencing company also appointed Scott Ullem, the CFO of Edwards Lifesciences, to the board, according to a company statement.

Illumina’s plans to add two new board members came as Carl Icahn waged a board proxy campaign culminating with shareholders electing his candidate, Andrew Teno, over board chair John Thompson. Illumina CEO Francis deSouza survived a threat to his board seat by securing more than twice the shareholder votes than his challenger. Another Illumina candidate, Robert Epstein, was also elected and remained on the board.

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Catal­ent makes ad­di­tion­al lay­offs at In­di­ana fa­cil­i­ty

Contract manufacturer Catalent is making more staff cuts at one of its locations in the US amid dramatic corrective actions it’s been taking over the past few months.

In an email to Endpoints News, a Catalent spokesperson confirmed the company is making “a number of personnel changes” at a manufacturing facility in Bloomington, IN. While a specific number was not given to Endpoints, several local media outlets, including Indiana Public Media and the Bloomington Herald-Times, have put the number of layoffs at 150. No postings have been made to the Indiana Department of Workforce Development’s WARN notice.

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Grail’s blood test charts path for di­ag­nos­ing pa­tients sus­pect­ed of hav­ing can­cer in large study: #AS­CO23

Grail’s vision is simple but bold. The blood testing company has long held that people are often diagnosed with cancer too late. If seemingly healthy people were screened for early signs of the disease before symptoms appear, they may be able to get more effective treatments that nip cancer in the bud.

That premise is the basis of Grail’s commercial blood test, Galleri, which searches for the genetic fingerprints of cancer in the blood. The test, launched in 2021, reaped $55 million in sales last year, but now the company is setting its sights on a new market: patients suspected of having cancer due to symptoms such as abdominal pain, rectal bleeding or unexplained weight loss. Rather than administering expensive scans or conducting invasive biopsies right away, Grail hopes doctors will consider a simple blood test.

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GSK pro­motes rou­tine im­mu­niza­tions for adults amid post-pan­dem­ic vac­cine back­slide

GSK launched a new initiative on Thursday and committed up to $1 million in grant funding to improve adult routine vaccination rates.

While the pandemic spotlight was trained on the race for novel Covid-19 vaccines, other routine vaccination rates plummeted, raising concerns that missed doses may put children and even some adults at risk of preventable diseases such as measles or shingles. The World Health Organization last year reported the largest drop in childhood vaccinations in roughly three decades.

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Tammie Denyse speaks up about Black women and breast cancer inequity in Gilead's first TikTok campaign. (Gilead Sciences)

Gilead joins Tik­Tok with on­col­o­gy aware­ness cam­paign fea­tur­ing di­verse group of can­cer ad­vo­cates

Gilead Sciences is taking over the opening page on TikTok for the next two weeks. A Gilead-sponsored video, featuring cancer advocates talking about equity and other issues, will show up as the landing page, called the “For You” page, for millions of TikTok watchers.

The cancer awareness campaign will begin on Monday and run for two weeks, a Gilead spokesperson told Endpoints News. The TikTok ad debut is timed around the ASCO medical conference, but the work is aimed more broadly at healthcare professionals, as well as people touched by cancer and people interested in advancing Black and general health equity.

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Novartis headquarters in Basel, Switzerland (Kyle LaHucik for Endpoints News)

No­var­tis’ Kisqali pre­vents breast can­cer from com­ing back for longer — but can it best Eli Lil­ly’s Verzenio? #AS­CO23

CHICAGO — Novartis’ CDK4/6 inhibitor Kisqali helped early breast cancer patients stay cancer-free for longer after surgery, according to interim study results presented at ASCO.

In a Phase III study, Kisqali was added on top of endocrine therapy — the current standard treatment for early breast cancer patients. Kisqali reduced the risk of disease relapse by 25% compared with endocrine therapy alone in patients with Stage II or III HR-positive, HER2-negative breast cancer.

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