MIT sci­en­tists look to un­lock po­ten­tial of ‘self-ad­ju­vant­i­ng’ mR­NA vac­cines in mice

Sci­en­tists at MIT have re­vamped mR­NA Covid jabs to boost their im­mune re­spons­es, po­ten­tial­ly paving the way for work on a new class of “self-ad­ju­vant­i­ng” mR­NA vac­cines.

New find­ings in mice stud­ies sug­gest that mR­NA vac­cines can be made “self-ad­ju­vant­i­ng” through spe­cif­ic de­sign al­ter­ations, pro­duc­ing a stronger im­mune re­sponse at a low­er dose. Cer­tain tra­di­tion­al vac­cines can have ad­ju­vants to en­hance im­mune stim­u­la­tion, but these have not been used in mod­ern mR­NA ap­proach­es to date.

Unlock this article instantly by becoming a free subscriber.

You’ll get access to free articles each month, plus you can customize what newsletters get delivered to your inbox each week, including breaking news.

SIGN UP LOG IN BECOME A PREMIUM SUBSCRIBER