MPM adds $408M for its next big wave of biotech star­tups — and on­col­o­gy still dom­i­nates the menu

MPM Cap­i­tal has put the fin­ish­ing touch­es to its 7th ven­ture fund — BV2018 — now tidi­ly tot­ting up to about $408 mil­lion as the ven­ture crew that runs this pro­lif­ic biotech deal­mak­er gets squared away for the next wave of in­vest­ments. Adding it up with their on­col­o­gy-on­ly funds, and the part­ners are work­ing with more than a bil­lion dol­lars.

Luke Evnin

Guid­ed by some close ex­pert con­nec­tions in the field, MPM has been keen on the on­col­o­gy R&D boom. Luke Evnin, who co-found­ed MPM in the late ‘90s, es­ti­mates that about 70% of MPM’s last fund went to fi­nance pro­grams for ex­per­i­men­tal can­cer drugs. In this next fund, he ex­pects the to­tal for can­cer to drop from that mark, but re­main the dom­i­nant field, tak­ing more than half its in­vest­ment cap­i­tal.

The last 5 years has seen im­muno-on­col­o­gy reach a peak, Evnin tells me. Dur­ing the next 3 or 4 years they’ll be fo­cused on one of the key mantras in biotech R&D: drug­ging the un­drug­gable. That could lead them to de­graders, syn­thet­ic lethal­i­ty or pro­tein-pro­tein in­ter­ac­tions, among oth­er fields. But wher­ev­er the bi­ol­o­gy of a drug tar­get is well known, you may well find MPM back­ing the hunt for a drug that can do the job.

MPM has had some re­cent IPOs from the port­fo­lio — Har­poon’s re­cent $76 mil­lion of­fer­ing for one — and Evnin is of the opin­ion the IPO win­dow will re­main open for busi­ness in 2019, though not quite as busy as last year. This next round of of­fer­ings will like­ly be lim­it­ed to more ma­ture com­pa­nies, he says, with the kind of deep-pock­et­ed in­sid­ers that can of­fer con­sid­er­able as­sis­tance.

Ans­bert Gadicke

Like a lot of new funds, MPM has a plan to back some 15 to 20 star­tups with their new mon­ey, which is al­ready be­ing di­rect­ed in­to the first round of in­vest­ments. But they have their own par­tic­u­lar Goldilocks ap­proach that will like­ly guide much of that. MPM wants to jump in­to launch rounds that are nei­ther too small to get any­thing done, nor too weight­ed to­ward mega-sized pack­ages that draw heat — from some sides — as too big for a start­up’s own good.

“Twen­ty mil­lion dol­lars runs out. You can’t get enough done,” says Evnin. But a syn­di­cate that brings in $50 mil­lion, look­ing to a non-di­lu­tive deal to fol­low up and then move on to a crossover and po­ten­tial IPO af­ter that, that sort of busi­ness strat­e­gy works well in this in­dus­try.

The cap­i­tal base for biotech right now is in sol­id shape, says Evnin. And so is the tal­ent pool all the VCs can draw from for their star­tups. That’s all en­cour­ag­ing as they look to the next 5 years and what’s ahead for the in­dus­try.

As Nas­daq en­rolls the fi­nal batch of 2019 IPOs, how have the num­bers com­pared to past years?

IGM Biosciences’ upsized IPO haul, coming after SpringWorks’ sizable public debut, has revved up some momentum for the last rush of biotech IPOs in 2019.

With 39 new listings on the books and roughly two more months to go before winding down, Nasdaq’s head of healthcare listings Jordan Saxe sees the exchange marking 50 to 60 biopharma IPOs for the year.

“December 15 is usually the last possible day that companies will price,” he said, as companies get ready for business talks at the annual JP Morgan Healthcare Conference in January.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 59,900+ biopharma pros reading Endpoints daily — and it's free.

A fa­vorite in Alex­ion’s C-suite is leav­ing, and some mighty sur­prised an­a­lysts aren’t the least bit hap­py about it

Analysts hate to lose a biotech CFO they’ve come to trust and admire — especially if they’re being blindsided by a surprise exit.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 59,900+ biopharma pros reading Endpoints daily — and it's free.

David Grainger [file photo]

'Dis­con­nect the bas­tard­s' — one biotech's plan to break can­cer cell­s' uni­fied de­fens­es

Chemotherapy and radiotherapy are the current gladiators of cancer treatment, but they come with well-known limitations and side-effects. The emergence of immunotherapy — a ferocious new titan in oncologist’s toolbox — takes the brakes off the immune system to kill cancer cells with remarkable success in some cases, but the approach is not always effective. What makes certain forms of cancer so resilient? Scientists may have finally pieced together a tantalizing piece of the puzzle, and a new biotech is banking on a new approach to fill the gap.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 59,900+ biopharma pros reading Endpoints daily — and it's free.

While No­var­tis ban­ish­es Zol­gens­ma scan­dal scars — Bio­gen goes on a Spin­raza 'of­fen­sive'

While Novartis painstakingly works to mop up the stench of the data manipulation scandal associated with its expensive gene therapy for spinal muscular atrophy (SMA) Zolgensma— rival Biogen is attempting to expand the use of its SMA therapy, Spinraza. 

The US drugmaker $BIIB secured US approval for Spinraza for use in the often fatal genetic disease in 2016. The approval covered a broad range of patients with infantile-onset (most likely to develop Type 1) SMA. 

Jason Kelly. Mike Blake/Reuters via Adobe

Eye­ing big ther­a­peu­tic push, Gink­go bags $290M to build a cell pro­gram­ming em­pire

Ginkgo Bioworks is on a roll. Days after publicizing a plan to nurture new startups via partnerships with accelerators Y Combinator and Petri, the Boston biotech says it has raised another $290 million for its cell programming platform to reach further and wider.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 59,900+ biopharma pros reading Endpoints daily — and it's free.

UP­DAT­ED: Speak­er Nan­cy Pelosi to un­veil bill for fed­er­al­ly ne­go­ti­at­ed drug prices

After months of buzz from both sides of the aisle, Speaker Nancy Pelosi will today introduce her plan to allow the federal government to negotiate prices for 250 prescription drugs, setting up a showdown with a pharmaceutical industry working overtime to prevent it.

The need to limit drug prices is a rare point of agreement between President Trump and Democrats, although the president has yet to comment on the proposal and will likely face pressure to back a more conservative option or no bill at all. Republican Senator Chuck Grassley is reportedly lobbying his fellow party members on a more modest proposal he negotiated with Democratic Senator Ron Wyden in July.

Jeff Kindler's Cen­trex­ion re­news bid to make pub­lic de­but

Jeffrey Kindler’s plan to take his biotech — which is developing a slate of non-opioid painkillers — public, is back on.

The Boston based company, led by former Pfizer $PFE chief Kindler, originally contemplated a $70 million to $80 million IPO last year— but eventually postponed that strategy. On Wednesday, the company revived its bid to make a public debut in a filing with the SEC — although no pricing details were disclosed.

Zachary Hornby. Boundless

'A fourth rev­o­lu­tion in can­cer ther­a­pies': ARCH-backed Bound­less Bio flash­es big check, makes big­ger promis­es in de­but

It was the cellular equivalent of opening your car door and finding an active, roaring engine in the driver seat.

Scientists learned strands of DNA could occasionally appear outside of its traditional home in the nucleus in the 1970s, when they appeared as little, innocuous circles on microscopes; inexplicable but apparently innate. But not until UC San Diego’s Paul Mischel published his first study in Science in 2014 did researchers realize these circles were not only active but potentially overactive and driving some cancer tumors’ superhuman growth.

Scott Gottlieb, AP Images

Scott Got­tlieb is once again join­ing a team that en­joyed good times at the FDA un­der his high-en­er­gy stint at the helm

Right after jumping on Michael Milken’s FasterCures board on Monday, the newly departed FDA commissioner is back today with news about another life sciences board post that gives him a ringside chair to cheer on a lead player in the real-world evidence movement — one with very close ties to the FDA.

Aetion is reporting this morning that Gottlieb is joining their board, a group that includes Mohamad Makhzoumi, a general partner at New Enterprise Associates, where Gottlieb returned after stepping out of his role at the FDA 2 years after he started.

Gottlieb — one of the best connected execs in biopharma — knows this company well. As head of FDA he championed the use of real-world evidence to help guide drug developers and the agency in gaining greater efficiencies, which helped set up Aetion as a high-profile player in the game.

Endpoints News

Keep reading Endpoints with a free subscription

Unlock this story instantly and join 59,900+ biopharma pros reading Endpoints daily — and it's free.