No speedy nasal roll­out for Ox­ford/As­traZeneca’s Covid-19 jab af­ter PhI flop

Ox­ford/As­traZeneca’s nasal spray vac­cine per­formed poor­ly in an ear­ly-stage study, squash­ing hopes for a quick ad­vance­ment of the duo’s orig­i­nal for­mu­la­tion via an in­oc­u­la­tion at SARS-CoV-2’s en­try­way.

A small study at one site in the UK re­vealed a bleak out­look for a nasal ver­sion of one of the top-ad­min­is­tered Covid-19 vac­cines in the world, be­hind break­outs Pfiz­er/BioN­Tech and Mod­er­na. The Phase I study in­clud­ed 30 pa­tients who hadn’t pre­vi­ous­ly re­ceived a Covid-19 jab and 12 pa­tients who test­ed the nasal vac­cine as a boost­er.

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