One of Hal Bar­ron's top drug prospects at GSK flunks a PhII test for rheuma­toid arthri­tis, flail­ing in an in­tense­ly com­pet­i­tive field

One of Glax­o­SmithK­line’s $GSK top pipeline can­di­dates has failed a Phase II tri­al — bad­ly.

The phar­ma gi­ant re­port­ed to­day that their an­ti-GM-CSF — GSK3196165, held up as a top drug can­di­date by new R&D chief Hal Bar­ron in a re­cent in­ter­view — failed the pri­ma­ry end­point of DAS28(CRP) < 2.6 at Week 24.

GSK did pull out some pos­i­tive sec­on­daries, but in an in­tense­ly com­pet­i­tive field where oth­er play­ers have been tout­ing much bet­ter, sta­tis­ti­cal­ly sig­nif­i­cant pri­ma­ry goal re­sults, the fu­ture of this drug is very much in doubt.

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