Open wa­ter: NI­BR chief Jay Brad­ner part­ners with UC Berke­ley on pro­tein drug re­search in­sti­tute

Al­most ex­act­ly two years to the day since he was named head of the No­var­tis In­sti­tutes for Bio­Med­ical Re­search, Jay Brad­ner is cel­e­brat­ing the an­niver­sary with a new col­lab­o­ra­tion with top in­ves­ti­ga­tors at UC Berke­ley fo­cus­ing on pro­tein drug re­search.

In­spired by the land­mark al­liance with Penn that re­cent­ly led to the ap­proval of the world’s first CAR-T drug, Brad­ner is div­ing deep in­to a field he was al­ready im­mersed in as a re­searcher at Dana-Far­ber. In do­ing so he plans to take co­va­lent bind­ing to a whole new lev­el in search of new break­throughs that can start hit­ting some cur­rent­ly “un­drug­gable” tar­gets.

The deal cre­ates the new No­var­tis-Berke­ley Cen­ter for Pro­teomics and Chem­istry Tech­nolo­gies, which will be led by Berke­ley’s Daniel No­mu­ra with an eye to get­ting the sci­en­tists at each cam­pus work­ing to­geth­er on some com­mon goals.

“This col­lab­o­ra­tion re­al­ly checks all the box­es,” Brad­ner tells me. It’s im­por­tant chem­istry with a tru­ly out­stand­ing group of in­ves­ti­ga­tors out to ad­dress in­tractable tar­gets. And it helps de­fine the open dis­cov­ery frame­work that No­var­tis is still work­ing on, with more such part­ner­ships planned for the fu­ture.

“More and more,’ says Brad­ner, “this best prac­tice ought to be our stan­dard prac­tice.”

The col­lab­o­ra­tion will seek out ir­re­versibly bind­ing mol­e­cules, he notes, while al­so fol­low­ing a path in search of next-gen ap­proach­es to pro­tein degra­da­tion, some­thing along the lines that his last Dana-Far­ber biotech spin­off — C4 — is en­gaged on. The goal is to “en­gage the ubiq­ui­tin/pro­tea­some sys­tem in a new way.”

Brad­ner spent much of his first year at NI­BR, one of the world’s largest dis­cov­ery or­ga­ni­za­tions with around 6,000 staffers, do­ing some re­struc­tur­ing and re­align­ment. That called for grow­ing chem­i­cal bi­ol­o­gy ex­per­tise while re­lo­cat­ing the trop­i­cal dis­ease group from Sin­ga­pore to a base in Emeryville, CA. NI­BR al­so moved to re­gen­er­ate its res­pi­ra­to­ry dis­ease re­search group. And more re­cent­ly Brad­ner de­light­ed in re­cruit­ing new tal­ent — most no­tably UCSF car­dio ex­pert Shaun Cough­lin — in­to the or­ga­ni­za­tion while pro­mot­ing oth­ers from with­in.

Says Brad­er: “This has ruth­less­ly been the search for the strongest swim­mer.”

Now the fo­cus is on cre­at­ing more of these ex­ter­nal part­ner­ships, while let­ting the sci­en­tists in­volved do some blue sky think­ing about what they can ac­com­plish.

“I have to tell you,” he adds, “I have found that No­var­tis is most com­fort­able in open wa­ter.”

Whether it works or not will be de­ter­mined by the num­ber and qual­i­ty of the new drugs they steer to ap­provals in the world’s big drug ports.


Im­age: Jay Brad­ner (mid­dle) File Pho­to

M&A: a crit­i­cal dri­ver for sus­tain­able top-line growth in health­care

2021 saw a record $600B in healthcare M&A activity. In 2022, there is an anticipated slowdown in activity, however, M&A prospects remain strong in the medium to long-term. What are future growth drivers for the healthcare sector? Where might we see innovations that drive M&A? RBC’s Andrew Callaway, Global Head, Healthcare Investment Banking discusses with Vito Sperduto, Global Co-Head, M&A.

15 LGBTQ lead­ers in bio­phar­ma; Paul Stof­fels’ Gala­pa­gos re­vamp; As­traZeneca catch­es up in AT­TR; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

A return to in-person conferences also marks a return to on-the-ground reporting. My colleagues Beth Synder Bulik and Nicole DeFeudis were on-site at Cannes Lions, bringing live coverage of pharma’s presence at the ad festival — accompanied by photos from Clara Bui, our virtual producer, that bring you right to the scene. You can find a recap (and links to all the stories) below.

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Abortion-rights protesters regroup and protest following Supreme Court's decision to overturn Roe v. Wade. (AP Photo/Gemunu Amarasinghe)

Fol­low­ing SCO­TUS de­ci­sion to over­turn abor­tion pro­tec­tions, AG Gar­land says states can't ban the abor­tion pill

Following the Supreme Court’s historic decision on Friday to overturn Americans’ constitutional right to an abortion after almost 50 years, Attorney General Merrick Garland sought to somewhat reassure women that states will not be able to ban the prescription drug sometimes used for abortions.

Following the decision, the New England Journal of Medicine also published an editorial strongly condemning the reversal, saying it “serves American families poorly, putting their health, safety, finances, and futures at risk.”

AstraZeneca's new Evusheld direct to consumer campaign aims to reach more immunocompromised patients.

As­traZeneca de­buts first con­sumer cam­paign for its Covid-19 pro­phy­lac­tic Evusheld — and a first for EUA drugs

AstraZeneca’s first consumer ad for Evusheld is also a first for drugs that have been granted emergency use authorizations during the pandemic.

The first DTC ad for a medicine under emergency approval, the Evusheld campaign launching this week aims to raise awareness among immunocompromised patients — and spur more use.

Evusheld nabbed emergency authorization in December, however, despite millions of immunocompromised people looking for a solution and now more widespread availability of the drug.

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GSK says its drug for chron­ic hep B could ‘lead to a func­tion­al cure’ — but will it be alone or in com­bi­na­tion?

GSK, newly branded and soon-to-be demerged, shared interim results from its Phase II trial on its chronic hepatitis B treatment, one that it says has the “potential to lead to a functional cure.”

At a presentation at the EASL International Liver Congress, GSK shared that in around 450 patients who received its hep B drug bepirovirsen for 24 weeks, just under 30% had hepatitis B surface antigen and viral DNA levels that were too low to detect.

Sanofi, GSK tout 72% Omi­cron ef­fi­ca­cy in PhI­II tri­al of next-gen, bi­va­lent shot — with an eye to year-end roll­out

Sometimes, being late can give you an advantage.

That’s what Sanofi and GSK are trying to say as the Big Pharma partners report positive results from a late-stage trial of their next-gen bivalent Covid-19 vaccine, which was designed to protect against both the original strain of the SARS-CoV-2 virus and the Beta variant. Specifically, against Omicron, they note, the vaccine delivered 72% efficacy in all adults and 93.2% in those previously infected.

Matt Kapusta, uniQure CEO

In trou­bled Hunt­ing­ton’s space, uniQure’s gene ther­a­py shows ear­ly promise

In randomized clinical trial data from a small number of patients, Dutch biotech uniQure shared that its gene therapy for Huntington’s disease seems to reduce the amount of the mutant protein responsible for the disease over the course of a year.

In seven patients with early-stage Huntington’s — four who got the treatment and three who got a placebo — mutant huntingtin protein levels in the cerebrospinal fluid decreased by an average of just over 50% in patients who got the gene therapy compared to around a 17% drop in patients who got the placebo after a year.

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De­spite a slow start to the year for deals, PwC pre­dicts a flur­ry of ac­tiv­i­ty com­ing up

Despite whispers of a busy year for M&A, deal activity in the pharma space is actually down 30% on a semi-annualized basis, according to PwC’s latest report on deal activity. But don’t rule out larger deals in the second half of the year, the consultants said.

PwC pharmaceutical and life sciences consulting solutions leader Glenn Hunzinger expects to see Big Pharma companies picking up earlier stage companies to try and fill pipeline gaps ahead of a slew of big patent cliffs. Though a bear market continues to maul the biotech sector, Hunzinger said recent deals indicate that pharma companies are still paying above current trading prices.

Joe Wiley, Amryt Pharma CEO

Am­ryt Phar­ma sub­mits a for­mal dis­pute res­o­lu­tion to the FDA over re­ject­ed skin dis­ease drug

The story of Amryt Pharma’s candidate for the genetic skin condition epidermolysis bullosa, or EB, will soon enter another chapter.

After the Irish drugmaker’s candidate, dubbed Oleogel-S10 and marketed as Filsuvez, was handed a CRL earlier this year, the company announced in a press release that it plans to submit a formal dispute resolution request for the company’s NDA for Oleogel-S10.