Pierre Beau­rang hits the ground run­ning at his 3rd start­up; Mike Grey poach­es Astel­las deal­mak­er to head pro­tein degra­da­tion play­er

Pierre Beau­rang

As Ni­trome Bio­sciences — a biotech found­ed in 2017 to fo­cus on a class of en­zymes called ni­trases — re­brands to Ni­trase Ther­a­peu­tics, the com­pa­ny is al­so bring­ing on a new CEO: Pierre Beau­rang.

In Ni­trase’s state­ment ear­li­er this week an­nounc­ing its new CEO, the biotech said that the founder and now-for­mer CEO — Irene Gris­wold-Pren­ner — will stay on with Ni­trase as the new CSO. And this new ap­point­ment comes in tan­dem with the biotech’s Se­ries A ex­pan­sion, where Bris­tol My­ers Squibb be­came an in­vestor along­side Ab­b­Vie and Sofinno­va Part­ners, bring­ing the to­tal amount raised to $45 mil­lion.

If you rec­og­nize Beau­rang’s name, you may re­mem­ber him as the for­mer CBO at Nurix — and as one of the found­ing team mem­bers at Five Prime Ther­a­peu­tics two decades ago.

Irene Gris­wold-Pren­ner

Beau­rang first start­ed in the bio sphere at Boston Uni­ver­si­ty, where he grad­u­at­ed with his bach­e­lor’s and mas­ter’s in bi­ol­o­gy and biotech­nol­o­gy — be­fore mov­ing to UC-Berke­ley to earn a PhD in mol­e­c­u­lar and cell bi­ol­o­gy.

Af­ter Berke­ley, he was a part of the team that found­ed Five Prime back in 2001 — where he spent the next 16 years work­ing up to ex­ec­u­tive di­rec­tor of busi­ness de­vel­op­ment. And he was on­ly in that po­si­tion for less than a year be­fore go­ing over to Nurix.

When we spoke with Beau­rang, he told us that he took the po­si­tion at Ni­trase for three rea­sons: be­cause of the op­por­tu­ni­ty it pro­vid­ed; be­cause it fit his 3 per­son­al “Ps” that he looks for in op­por­tu­ni­ties — peo­ple, plat­form, and pipeline; and be­cause it felt like Nurix and Five Prime.

“One of the feel­ings I felt when I was ap­proached about this op­por­tu­ni­ty is that it re­mind­ed me very much of what Nurix was when I joined that com­pa­ny sev­en years ago. At Ni­trase, to say we’re the lead­ers in ni­trase ther­a­peu­tics? That’s — that’s true. When I joined Nurix, at that time, we were say­ing we were the lead­ers in lig­ase ther­a­peu­tics, and that was true at that time,” Beau­rang said.

“And we want­ed to own that space, just like we are own­ing the space in net­works or build­ings. And so there were a lot of sim­i­lar­i­ties there. And again, the same thing — the peo­ple, the plat­form, the ear­ly pipelines — all those things were kind of aligned with them­selves,” Beau­rang added. “And that takes me back to what we did at Five Prime in the very ear­ly days, again, hav­ing the right peo­ple, build­ing a plat­form that can fill the pipeline, those three el­e­ments.”

Since Beau­rang came on board at Ni­trase two months ago, he has had a few ob­jec­tives to kick off his time as CEO — from ex­pand­ing Ni­trase’s R&D in dif­fer­ent ther­a­peu­tic ar­eas to hir­ing on more em­ploy­ees and po­si­tion­ing the com­pa­ny for po­ten­tial part­ner­ships.

The San Fran­cis­co biotech has a lead pro­gram po­ten­tial­ly for Parkin­son’s dis­ease, tar­get­ing a ni­trase for the pop­u­lar synu­cle­in tar­get — which, ac­cord­ing to Beau­rang, formed the ba­sis of Ni­trase’s plat­form. The team is al­so look­ing at di­ver­si­fy­ing its pipeline in­to on­col­o­gy, fi­brot­ic dis­eases and im­munol­o­gy.

And since the com­pa­ny has on­ly 17 or so em­ploy­ees, the num­ber of em­ploy­ees will change, de­pend­ing on what part­ner­ships or oth­er projects Ni­trase takes on. As for more specifics? You’ll have to wait for those.

Paul Schloess­er


Per­ci­val Bar­ret­to-Ko

→ Back in Jan­u­ary, Plex­i­um put more cash in the hop­per with a $35 mil­lion Se­ries B and made ex-Am­plyx CEO Mike Grey chair­man. The San Diego pro­tein degra­da­tion biotech has poached Per­ci­val Bar­ret­to-Ko from Astel­las to be pres­i­dent and CEO, suc­ceed­ing Swamy Vi­jayan and end­ing a 16-year run at the Japan­ese phar­ma. A mere nine months ago, Bar­ret­to-Ko took the CBO job at Astel­las af­ter three years as pres­i­dent of Astel­las US. This marks the sec­ond straight week that a pro­tein degra­da­tion com­pa­ny based in San Diego has named a chief ex­ec­u­tive fol­low­ing the ap­point­ment of Bio­Th­eryX CEO Philippe Drou­et.

Aaron Cox

→ Paul Hoelsch­er has an­nounced his re­tire­ment as CFO of Hori­zon Ther­a­peu­tics, which is turn­ing to one of their own to suc­ceed him. Hoelsch­er steps aside on May 16, 2022, in fa­vor of Aaron Cox, a Hori­zon staffer since 2016 who earns the ti­tle of EVP, fi­nance un­til he takes over. A for­mer ex­ec at BMO Cap­i­tal Mar­kets, Cox had been SVP of busi­ness de­vel­op­ment the last four years at the Dublin-based biotech that bought As­traZeneca spin­off Viela Bio and its neu­romyelitis op­ti­ca spec­trum dis­or­der (NMOSD) drug Up­liz­na for $3 bil­lion in Feb­ru­ary. Hoelsch­er will re­main with Hori­zon in an ad­vi­so­ry role un­til May 2023.

An­drew Drech­sler

→ On the sub­ject of CFO re­tire­ments, there’s an­oth­er one tak­ing place at Proven­tion Bio as An­drew Drech­sler has de­cid­ed to hang up the cleats af­ter four years on the job and al­most 30 years in the busi­ness over­all. Proven­tion Bio has al­ready lined up Alex­ion’s Thier­ry Chauche to take over as fi­nance chief on Dec. 1, and Drech­sler will stay un­til mid-2002 as a spe­cial ad­vi­sor to CEO Ash­leigh Palmer. Chauche was pre­vi­ous­ly the head of strate­gic fi­nan­cial plan­ning and analy­sis at Alex­ion, which is ex­pe­ri­enc­ing a con­sis­tent drain in tal­ent fol­low­ing the sale to As­traZeneca. Ear­li­er, Chauche was VP of FP&A at In­ter­cept and has a Big Phar­ma back­ground at No­var­tis and Bris­tol My­ers Squibb.

Fabi­an Tenen­baum

Fabi­an Tenen­baum has in­formed Peer Re­view that he has been ap­point­ed CEO of Is­raeli im­muno-on­col­o­gy start­up Nectin Ther­a­peu­tics as it de­vel­ops a pipeline that in­cludes AD­Cs, CAR-T and CAR-NK cell ther­a­pies. Tenen­baum, the for­mer CEO of Bellerophon Ther­a­peu­tics, has al­so been CBO and CFO of An­te­rios Ther­a­peu­tics, which was sold to Al­ler­gan for $90 mil­lion up­front at the start of 2016.

An­ni­ka Muskan­tor

→ It hasn’t been peach­es and cream at all for On­copep­tides late­ly — a cou­ple weeks ago its mul­ti­ple myelo­ma drug Pepax­to got yanked from the US mar­ket, which in turn pum­meled the stock. A week ear­li­er, CFO An­ders Mar­tin-Löf re­signed for per­son­al rea­sons af­ter three years on the job, and the Stock­holm biotech has turned to An­ni­ka Muskan­tor to suc­ceed him in an in­ter­im ca­pac­i­ty be­gin­ning Mon­day. Muskan­tor, most re­cent­ly the fi­nance chief at Stock­holm-based Frisq, has been an in­ter­im group CFO be­fore at Sci­en­ta Omi­cron and So­bi, among oth­er com­pa­nies.

Stew­art Camp­bell

→ Last week Ipsen CBO Philippe Lopes-Fer­nan­des gave our Nicole De­Feud­is an in­side look at the com­pa­ny in the year since he took the job, and now Ipsen has giv­en Stew­art Camp­bell a dif­fer­ent role: EVP and pres­i­dent of North Amer­i­ca. Just this year, Camp­bell joined CEO David Loew’s squad as SVP and fran­chise head of on­col­o­gy fol­low­ing a 15-year run at Roche/Genen­tech that saw him take on a col­lage of roles work­ing with such block­busters as Rit­ux­an and Kad­cy­la, end­ing with his time as life­cy­cle leader, glob­al prod­uct strat­e­gy.

Stephanie Brown

→ Swiss-based San­thera has been rid­ing the strug­gle bus for awhile, punc­tu­at­ed by a sig­nif­i­cant re­duc­tion in its staff af­ter scrap­ping a Duchenne mus­cu­lar dy­s­tro­phy pro­gram in Oc­to­ber 2020. But hit­ting the pri­ma­ry end­point with an­oth­er Duchenne drug, va­morolone, in a Phase IIb study has giv­en San­thera rea­son for op­ti­mism, and Stephanie Brown will be pres­i­dent, North Amer­i­ca start­ing Dec. 1. Brown’s ca­reer is a ver­i­ta­ble Big Phar­ma sam­pler, tak­ing on lead­er­ship po­si­tions at Take­da, Bio­gen, Mer­ck and Genen­tech. She will jump to San­thera next month af­ter clos­ing out her tenure as Ipsen’s SVP and head of the rare dis­eases fran­chise, North Amer­i­ca.

Vick­ie Reed

→ Ac­cord­ing to an SEC fil­ing Mon­day, both COO Daniel Fa­ga and CMO Joseph Lev­eque are out at Mi­rati, while chief ac­count­ing of­fi­cer Vick­ie Reed has stepped in­to the role of CFO. Af­ter his Fer­Gene flame­out, David Meek will now re­tool his lead­er­ship a month and a half in­to his tenure as CEO, shep­herd­ing Mi­rati through an NDA slat­ed for Q4 with a KRAS in­hibitor that it hopes can put a dent in Am­gen’s Lumakras in non-small cell lung can­cer. Mi­rati al­so took the wraps off pos­i­tive colon can­cer da­ta for that same drug, ada­gra­sib, in Sep­tem­ber.

→ On Dec. 3, Er­ic Mur­phy will walk away as CSO of Ni­ma Farzan’s can­cer biotech Kin­nate Bio­phar­ma “to pur­sue a new op­por­tu­ni­ty.” This isn’t good­bye com­plete­ly for Mur­phy, who stays on as a mem­ber of the sci­en­tif­ic ad­vi­so­ry board at the Cal­i­for­nia-based de­vel­op­er of small mol­e­cule ki­nase in­hibitors. Af­ter a whop­ping $276 mil­lion IPO at the tail end of the 2020 gold rush, Kin­nate es­tab­lished a sub­sidiary in Shang­hai with the as­sis­tance of Or­biMed and Fore­site Cap­i­tal in May.

Jielun Zhu

→ Fresh off a new al­liance with Sinopharm, Shang­hai-based I-Mab has shift­ed CFO Jielun Zhu to chief strat­e­gy of­fi­cer and named John Long as fi­nance lead in his stead. Zhu, the CFO since Au­gust 2018, steered I-Mab to an IPO that cracked the $100 mil­lion mark in Jan­u­ary 2020, the first Chi­nese biotech to hit Nas­daq since Saman­tha Du’s Zai Lab in 2017. Long will be­come part of I-Mab’s board of di­rec­tors and has pre­vi­ous­ly been SVP of fi­nance at WuXi AppTec.

→ San Diego-based Aca­dia — forced by the FDA to re­assess its sN­DA for Nu­plazid af­ter the agency sad­dled the neu­ro biotech with a CRL in April — has pro­mot­ed Bren­dan Tee­han to EVP, COO, head of com­mer­cial. Tee­han has swift­ly climbed the lad­der here af­ter join­ing Aca­dia in 2018 as VP, com­mer­cial in­sights, an­a­lyt­ics & op­er­a­tions; since Jan­u­ary he had held the ti­tle of chief in­sights and an­a­lyt­ics of­fi­cer. The J&J and Am­gen vet al­so logged two years as VP, provider so­lu­tions at Tesaro.

Marc Rudoltz

Tan­go in the night: Un­der the lead­er­ship of Bar­bara We­ber, pre­ci­sion on­col­o­gy play­er Tan­go Ther­a­peu­tics found a dance part­ner to light up the biotech ball­room in April, re­verse merg­ing with Box­er Cap­i­tal’s blank-check com­pa­ny BCTG Ac­qui­si­tion Corp. Tan­go has now tapped Marc Rudoltz as CMO and Doug Bar­ry as gen­er­al coun­sel to shore up the lead­er­ship. Rudoltz is a No­var­tis vet in clin­i­cal de­vel­op­ment (with Gleevec and Tasigna) who has held the CMO job on an in­ter­im ba­sis at Wind­MIL Ther­a­peu­tics, De­ci­phera Phar­ma­ceu­ti­cals and Con­stel­la­tion Phar­ma­ceu­ti­cals. Bar­ry was pre­vi­ous­ly VP of cor­po­rate law at Alex­ion.

Christo­pher Lea­mon

→ As ra­dio­phar­ma con­tin­ues to siz­zle, Fu­sion Phar­ma­ceu­ti­cals — a Cana­di­an biotech in the space that burst on­to Nas­daq with a $212.5 mil­lion IPO last sum­mer — has se­lect­ed Christo­pher Lea­mon as CSO. Lea­mon was VP of re­search and lat­er pres­i­dent of En­do­cyte, the ra­dio­phar­ma­ceu­ti­cal play­er No­var­tis bought in 2018 for $2.1 bil­lion. And just be­fore he took this gig at Fu­sion, Lea­mon served as No­var­tis’ ex­ec­u­tive di­rec­tor, ra­di­oli­gand drug dis­cov­ery. Er­ic Bu­rak, Fu­sion’s on­ly oth­er chief sci­en­tist since its launch, will now shift to chief tech­nol­o­gy of­fi­cer.

Joel Bar­rish

Roche im­munol­o­gy and neu­rol­o­gy part­ner Jnana Ther­a­peu­tics has bumped up its co-founder Joel Bar­rish to pres­i­dent and CSO. A 27-year vet­er­an of Bris­tol My­ers, Bar­rish helped found Jnana af­ter a short stay as CSO of Achillion, and he’s al­so on the sci­en­tif­ic ad­vi­so­ry board at Ko­jin Ther­a­peu­tics, led by new CEO Lu­ba Green­wood. The Stu­art Schreiber-found­ed Jnana, fo­cused on solute car­ri­er (SLC) trans­porters, en­joyed a $50 mil­lion Se­ries B haul in Au­gust that was head­lined by RA Cap­i­tal.

Sta­cy Price

→ Boston hear­ing loss biotech Ak­ou­os has named Sta­cy Price as chief tech­ni­cal of­fi­cer, its first ma­jor hire since ex-Spark CMO Kathy Reape joined Man­ny Si­mons’ team in ear­ly May as chief de­vel­op­ment of­fi­cer. Price es­capes the dra­ma at Zio­pharm On­col­o­gy — now un­der new man­age­ment af­ter the ac­tivist at­tack brouha­ha — where she was SVP of tech­ni­cal op­er­a­tions. While with Shire, Price led phar­ma­ceu­ti­cal de­vel­op­ment op­er­a­tions and was in charge of CMC pro­gram man­age­ment.

→ Blend­ing to­geth­er with K5 Ther­a­peu­tics and gath­er­ing up a Se­ries A in Ju­ly co-led by No­vo Hold­ings and Sofinno­va Part­ners, Dan­ish neu­rode­gen­er­a­tive dis­ease com­pa­ny Mu­na Ther­a­peu­tics has pegged Niels Plath as CSO. Plath had been a main­stay at a fa­mil­iar Dan­ish name, clos­ing out 16 years at Lund­beck as act­ing head of glob­al re­search and VP for neu­ro­science. Mu­na has its sights set on small mol­e­cule drugs for such dis­eases as Alzheimer’s, fron­totem­po­ral de­men­tia and Parkin­son’s.

Scott Gi­a­co­bel­lo

→ It didn’t take long for Los An­ge­les-based can­cer out­fit Aa­di Bio­science to resur­face in Peer Re­view, nam­ing Scott Gi­a­co­bel­lo CFO af­ter the ap­point­ment of CMO Loret­ta Itri last week. A for­mer fi­nance ex­ec for sev­en years at Al­ler­gan, Gi­a­co­bel­lo spent the last four years as CFO of GW Phar­ma­ceu­ti­cals, the mak­er of the cannabi­noid Epid­i­olex that Jazz Phar­ma­ceu­ti­cals scooped up in a $7.2 buy­out in Feb­ru­ary. Gi­a­co­bel­lo’s first day at Aa­di is Nov. 28.

→ J&J vet Frank Wie­gand has leapfrogged to Ox­ford-based Beck­ley Psytech, which re­ceived $80 mil­lion in Se­ries B fund­ing this sum­mer, as CMO. Be­fore piv­ot­ing to Beck­ley, which is de­vel­op­ing ther­a­pies de­rived from psilo­cy­bin and “toad ven­om” for se­vere headaches and treat­ment-re­sis­tant de­pres­sion, Wie­gand spent more than 20 years with J&J, round­ing out his time at the phar­ma gi­ant as VP, glob­al med­ical af­fairs in neu­ro­science.

Greg MacMichael

→ Hous­ton neu­ro start­up Coya Ther­a­peu­tics is build­ing out its lead­er­ship ros­ter fur­ther by wel­com­ing Adri­an Hep­n­er as CMO and Greg MacMichael as chief tech­ni­cal of­fi­cer. Hep­n­er jumps to Coya from his dou­ble du­ty at Pharnext as CMO and head of R&D, and he spent his pre­vi­ous five years as the med­ical chief of Ea­gle Phar­ma­ceu­ti­cals. An Eli Lil­ly and No­var­tis alum, MacMichael held the same ti­tle at Cas­tle Creek Bio­sciences and has been a man­u­fac­tur­ing ex­ec with Ax­o­vant, Nan­tK­west and Rock­et Phar­ma­ceu­ti­cals.

→ Gene, we hard­ly knew ye: Gene Mack seemed like he just took the CFO job 10 min­utes ago at Coya, but he’s al­ready had a change of heart and has be­come fi­nance chief at Im­cyse, a Bel­gian biotech de­vel­op­ing syn­thet­ic pep­tides called Imo­topes which is part­ner­ing with Pfiz­er on rheuma­toid arthri­tis ther­a­pies. Mack was pre­vi­ous­ly CFO at On­coIm­mune and its spin­out On­coC4.

David Kao

→ A tri­ad of new ex­ecs is hop­ing to strike the right chord at San Diego-based In­hi­brx, which rolled out re­sults in Oc­to­ber for its al­pha-1 an­tit­rypsin de­fi­cien­cy drug IN­BRX-101. Eli Lil­ly vet David Mat­ly (chief com­mer­cial of­fi­cer) climbs aboard af­ter four years at No­var­tis On­col­o­gy, and in his fi­nal year he was the glob­al leader of the MDS/AML port­fo­lio. David Kao (VP of reg­u­la­to­ry af­fairs) owns reg­u­la­to­ry ex­pe­ri­ence from Roche, Dai­ichi Sankyo and Re­cep­tos/Cel­gene and was re­cent­ly de­vel­op­ment pro­gram lead (im­muno­science) at Bris­tol My­ers. And af­ter 12 years at Sanofi Gen­zyme, Jack Tsai (VP of busi­ness de­vel­op­ment) had a year-long stay as Take­da’s on­col­o­gy and cell ther­a­py new prod­uct busi­ness de­vel­op­ment lead be­fore tak­ing on this role.

Fi­nal­ly, San­ford Burn­ham Pre­bys Med­ical Dis­cov­ery In­sti­tute pres­i­dent Kris­ti­ina Vuori has been added to In­hi­brx’s board of di­rec­tors.

Jen­nifer Mi­nai-Azary

→ Philadel­phia-based women’s can­cer biotech Con­text Ther­a­peu­tics has an­nounced two up­dates to its C-suite. Jen­nifer Mi­nai-Azary has tak­en over as CFO this month, and back in April, ex-Te­va as­so­ciate gen­er­al coun­sel Alex Lev­it was ap­point­ed chief le­gal of­fi­cer. Most re­cent­ly, Mi­nai-Azary served as CFO at Mil­len­do Ther­a­peu­tics, and Lev­it was VP, deputy gen­er­al coun­sel and as­sis­tant cor­po­rate sec­re­tary of Opti­Nose.

Kia Mote­sharei

→ One of the biotechs tack­ling the rid­dle wrapped in a mys­tery in­side of an enig­ma known as NASH, Penn­syl­va­nia-based Madri­gal Phar­ma­ceu­ti­cals has re­cruit­ed Stephen Dodge as glob­al head of med­ical af­fairs and Kia Mote­sharei as SVP, busi­ness & cor­po­rate de­vel­op­ment. Dodge worked in med­ical af­fairs at Mer­ck, No­vo Nordisk and No­var­tis, chang­ing course here af­ter two years at In­ter­cept that con­clud­ed as cholesta­sis pro­gram head. Mote­sharei just had a quick stay at an­oth­er com­pa­ny out of Penn­syl­va­nia, NeuBase Ther­a­peu­tics, as chief busi­ness and strat­e­gy of­fi­cer. The ex-Gen­fit CFO has al­so been a busi­ness de­vel­op­ment ex­ec at EMD Serono and Akcea.

Livi­ja De­ban

Livi­ja De­ban has been pro­mot­ed to CSO at Prokar­i­um, a mi­cro­bial im­munother­a­py biotech out of Lon­don with a lead pro­gram that tar­gets non-mus­cle in­va­sive blad­der can­cer. De­ban, a Prokar­i­um ex­ec since 2018, pre­vi­ous­ly got el­e­vat­ed to VP of re­search in 2020 from her orig­i­nal post — VP of im­munol­o­gy and on­col­o­gy. Kris­ten Al­bright re­ceived the ul­ti­mate pro­mo­tion in Ju­ly at Prokar­i­um, vault­ing to CEO af­ter a year as COO.

Ted Danse

Ted Danse has hit the ground run­ning as head of busi­ness de­vel­op­ment at Seat­tle pres­by­opia biotech Vi­s­us Ther­a­peu­tics, which bagged a $36 mil­lion Se­ries A in March. Danse, an Al­ler­gan and Scher­ing-Plough alum, is the ex-CEO of ISTA Phar­ma­ceu­ti­cals and Neu­rotech. Else­where at Vi­s­us, SV Health In­vestors ven­ture part­ner David Guy­er has been named chair­man of the board af­ter serv­ing as an ad­vi­sor since the com­pa­ny was found­ed in 2019.

→ CD­MO AGC Bi­o­log­ics has re­cruit­ed Jean-Bap­tiste Ag­nus as CBO. Ag­nus hails from Aji­nomo­to Bio-Phar­ma Ser­vices. Ad­di­tion­al­ly, Ag­nus has served at No­vasep and Isochem.

Bri­an John­son is mak­ing his way back to No­van to take back the man­tle of his for­mer job as CCO. John­son’s been busy since he part­ed ways with the com­pa­ny in 2018, busy work­ing stints at Two Hearts Group, UCB and Gal­der­ma. Ad­di­tion­al­ly, John­son for­mer­ly served at Re­vian, No­var­tis, Or­tho Phar­ma­ceu­ti­cal and Medicis.

→ Pa­lo Al­to, CA-based 180 Life Sci­ences has reeled in Quan Vu as COO/CBO. Vu hops aboard with ex­pe­ri­ence from his times at LS As­so­ci­ates, Baleena Bio­science, Opi­ant Phar­ma­ceu­ti­cals, An­them and Am­gen.

→ Hail to the vic­tors: Lo­cat­ed west of the Uni­ver­si­ty of Michi­gan, Stra­ta On­col­o­gy — a start­up that cap­tured a $90 mil­lion Se­ries C this sum­mer with the help of Mer­ck and Pfiz­er — has wel­comed Jen­nifer Reyn­t­jes as chief peo­ple of­fi­cer. Reyn­t­jes, who be­gan her ca­reer at Gen­er­al Mo­tors, comes from the an­i­mal health world af­ter a year and a half as chief hu­man re­sources of­fi­cer for Mis­sion Vet­eri­nary Part­ners.

Jinky Ang Rossel­li

BioCryst has pro­mot­ed Jinky Ang Rossel­li to the po­si­tion of chief da­ta and in­sights of­fi­cer. Rossel­li joined the NC-based com­pa­ny in 2015 as VP of glob­al busi­ness analy­sis and op­er­a­tions. She made her way over to BioCryst from Unit­ed Ther­a­peu­tics, where she led the glob­al busi­ness in­tel­li­gence and in­sight team. Pri­or to that, Rossel­li was with Tale­cris Bio­ther­a­peu­tics (now Gri­fols) and No­var­tis.

Bet­ter Ther­a­peu­tics is wel­com­ing aboard Thi­a­go Li­cias de Oliveira as chief peo­ple of­fi­cer. de Oliveira most re­cent­ly served as head of glob­al tal­ent man­age­ment for J&J Med­ical De­vices.

→ Surf’s up: Steven Spec­tor, who spent al­most 20 years as gen­er­al coun­sel at Are­na Phar­ma­ceu­ti­cals from 2001-20, has signed on at ex-Are­na sub Long­board Phar­ma­ceu­ti­cals in the same ca­pac­i­ty. Af­ter his de­par­ture from Are­na, Spec­tor worked part-time as a gen­er­al coun­sel and ad­vi­sor for not just Long­board, but Dy­navax and Galec­to as well. Mak­ing its de­but with a $56 mil­lion round in Oc­to­ber 2020, Long­board ven­tured off to Nas­daq in March through an $80 mil­lion IPO.

Alexan­der Bas­t­ian

→ Over in The Nether­lands, AM-Phar­ma has ap­point­ed Alexan­der Bas­t­ian as VP, val­ue and mar­ket ac­cess. Bas­t­ian held the same po­si­tion at Gala­pa­gos, which has im­plod­ed im­pres­sive­ly af­ter the fil­go­tinib fail with Gilead, be­fore mak­ing the leap to AM-Phar­ma. Back in Sep­tem­ber, AM-Phar­ma part­nered with Tokyo-based Ky­owa Kirin for ex­clu­sive de­vel­op­ment and com­mer­cial­iza­tion rights in Japan for its kid­ney drug, ilo­fo­tase al­fa.

→ While grab­bing a cool $275 mil­lion to help launch star­tups, Mis­sion Bio­Cap­i­tal has signed on Mike Tay­lor as op­er­at­ing part­ner and Steve Tre­gay as co-man­ag­ing part­ner. Tay­lor comes with ex­pe­ri­ence from his times at Pfiz­er, En­sem­ble Ther­a­peu­tics and De­ci­phera Phar­ma­ceu­ti­cals un­der his belt; while Tre­gay for­mer­ly served at No­var­tis and FOR­MA Ther­a­peu­tics.

Dave John­son

Brion Mur­ray has been ap­point­ed SVP of re­search at Lengo Ther­a­peu­tics, led by first-year CEO Enoch Kar­iu­ki. Be­fore join­ing the San Diego-based Lengo, Mur­ray was VP, can­cer bi­ol­o­gy and trans­la­tion­al re­search at Turn­ing Point Ther­a­peu­tics. He has al­so served as a re­search fel­low at Pfiz­er.

Speak­ing of Lengo, its chair­man Dave John­son has been added to the board of di­rec­tors at gly­co-im­munol­o­gy biotech Palleon Phar­ma­ceu­ti­cals, which racked up a nine-fig­ure Se­ries B last year to pro­pel its lead can­di­date — a en­zy­mat­ic sialo­gly­can de­grad­er — to­ward the clin­ic. John­son, the ex-CEO of Velos­Bio and Ac­er­ta Phar­ma, al­so chairs the board at Au­ra Bio­sciences.

Sheri Mc­Coy

→ If Laronde CEO Diego Mi­ralles start­ed singing the cho­rus of “We’re In the Mon­ey” af­ter the Flag­ship com­pa­ny’s gi­gan­tic $440 mil­lion Se­ries B in Au­gust, Peer Re­view wouldn’t be­grudge him. This week Sheri Mc­Coy and Pablo Cagnoni have been elect­ed to the board of di­rec­tors at Laronde, which is mak­ing a play at end­less RNA (eR­NA). Mc­Coy de­vot­ed 30 years to J&J and was the phar­ma gi­ant’s vice chair be­fore be­com­ing CEO of Avon, while Cagnoni has helmed Ru­bius Ther­a­peu­tics since 2018.

→ Long­time Gen­zyme vet Richard Dou­glas, who has been on the board at Max­Cyte since 2018, has now been ap­point­ed chair­man. Dou­glas, a board mem­ber at No­vavax, serves as an ad­vi­sor at Red­Sky Part­ners and is chair­man of Aldeyra Ther­a­peu­tics.

Seth Fis­ch­er

→ Back in Oc­to­ber, Es­pe­ri­on an­nounced that it would cut 40% of its staff due to bud­get con­cerns over the course of the month and there’s al­so been a change at the top. On the brighter side of things, the biotech has an­nounced the ap­point­ment of Seth Fis­ch­er to its board of di­rec­tors. Fis­ch­er, a J&J alum, al­so serves as a board mem­ber for Ag­ile Ther­a­peu­tics, Spec­trum Phar­ma­ceu­ti­cals and Mar­i­nus Phar­ma­ceu­ti­cals.

→ J&J alum Tom Graney is the lat­est mem­ber of the board of di­rec­tors at Cam­bridge, UK start­up Mo­gri­fy, which just brought in CSO Louise Modis last month. Graney, the cur­rent CFO at Ox­u­ri­on, al­so held that role at Iron­wood, Ver­tex and Gen­er­a­tion Bio.

Mon­i­ca Shaw

→ Graney is on the board of An­drea Pfeifer-led AC Im­mune, which is chaired by Co­di­ak CEO Doug Williams and al­so in­cludes Carl June and Evotec CEO Wern­er Lan­thaler — and has grown fur­ther with the ad­di­tions of Mon­i­ca Shaw and Moni­ka Bütler. Shaw is Leo Phar­ma’s EVP, head re­gion for Eu­rope, Cana­da and Aus­tralia, and Bütler is an econ­o­mist who’s a board mem­ber with Schindler Group and Hu­ber+Suh­n­er.

Ron Frieson

→ Ane­mia-fo­cused Ake­bia Ther­a­peu­tics has a seat ready for Ron Frieson on the board of di­rec­tors. A for­mer chair­man of the Amer­i­can Kid­ney Fund’s board of trustees, Frieson is COO at Chil­dren’s Health­care of At­lanta.

→ Af­ter nam­ing at­tor­ney Ken Clark to the board of di­rec­tors a month ago, Bob Dug­gan’s Sum­mit Ther­a­peu­tics has ap­point­ed Urte Gayko to the board this week. Gayko worked for Dug­gan in reg­u­la­to­ry af­fairs at Phar­ma­cyclics in the 2010s and she’s now the SVP of drug de­vel­op­ment & reg­u­la­to­ry af­fairs for Nek­tar.

→ For­mer Bris­tol My­ers and Am­gen R&D ex­ec El­liott Levy has joined the board of di­rec­tors at UK-based Nu­Cana. Back in May, Levy be­came a board mem­ber at Omega Ther­a­peu­tics and he pre­vi­ous­ly chaired the board at Tran­sCel­er­ate Bio­Phar­ma.

Bri­a­Cell Ther­a­peu­tics has wel­comed Jane Gross to its board of di­rec­tors. Gross has pre­vi­ous­ly served as CSO and SVP, re­search and non-clin­i­cal de­vel­op­ment at Apte­vo Ther­a­peu­tics and was VP, ap­plied re­search and non-clin­i­cal de­vel­op­ment at Emer­gent BioSo­lu­tions.

Robin An­drule­vich

Ace­po­dia has re­cruit­ed a cou­ple in­dus­try vet­er­ans to its board of di­rec­tors and sci­en­tif­ic ad­vi­so­ry board. Robin An­drule­vich, who cur­rent­ly serves as EVP and chief peo­ple of­fi­cer at Sana Biotech­nol­o­gy, will join the board of di­rec­tors. For the SAB, Ace­po­dia brings on Eileen High­am, who serves as SVP, head of tech­ni­cal op­er­a­tions at In­ter­galac­tic Ther­a­peu­tics.

Adi­al Phar­ma­ceu­ti­cals is adding for­mer In­di­v­ior CFO Cary Clai­borne to its board of di­rec­tors. In ad­di­tion to his past role at In­di­v­ior, Clai­borne has served as CFO of Su­cam­po Phar­ma­ceu­ti­cals and Osiris Ther­a­peu­tics.

Kathy La­Porte is tack­ing on an­oth­er board ap­point­ment to her ré­sumé with her lat­est ad­di­tion to 89bio. La­Porte for­mer­ly served as CEO of Nodal­i­ty and cur­rent­ly sits on the boards of Bolt Ther­a­peu­tics, Pre­ci­pio and Phoenix Biotech Ac­qui­si­tion Cor­po­ra­tion.

The Big Phar­ma dis­card pile; Lay­offs all around while some biotechs bid farewell; New Roche CEO as­sem­bles top team; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

With earnings seasons in full swing, we’ve listened in on all the calls so you don’t have to. But news is popping up from all corners, so make sure you check out our other updates, too.

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Sen. Ron Wyden (D-OR) (Francis Chung/E&E News/Politico via AP Images)

In­fla­tion re­bates in­com­ing: Wyden calls on CMS to move quick­ly as No­var­tis CEO pledges re­ver­sal

Senate Finance Chair Ron Wyden (D-OR) this week sent a letter to the head of the Centers for Medicare & Medicaid Services seeking an update on how and when new inflation-linked rebates will take effect for drugs that see major price spikes.

The newly signed Inflation Reduction Act requires manufacturers to pay a rebate to Medicare when they increase drug prices faster than the rate of inflation.

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Af­ter 13 years, Ramy Mah­moud steps in­to CEO seat at Opti­nose; Ru­pert Vessey set to ex­it Bris­tol My­ers in Ju­ly

After 13 years as president and COO at Optinose, Ramy Mahmoud has stepped into a new role as its CEO. He is taking the place of Peter Miller, who stepped down earlier this week, though Miller is still staying with the company as a consultant.

In 2010, the two business partners joined Optinose to take it in a new direction, transforming it from a delivery platform to product company. They previously worked together at Johnson & Johnson, when Miller was president at Janssen and Mahmoud headed medical affairs. Miller said after he learned about Optinose, “I did what I always do, which is find people smarter than me to talk with about the idea. And the first person I called was Ramy … and I said, ‘Hey, Ramy, what do you think of this technology?’”

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Trodelvy notch­es a win in most com­mon form of breast can­cer

Following a promise last year to go “big and fast in breast cancer,” Gilead has secured a win for Trodelvy in the most common form.

The drug was approved to treat HR-positive, HER2-negative breast cancer patients who’ve already received endocrine-based therapy and at least two other systemic therapies for metastatic cancer, Gilead announced on Friday.

Trodelvy won its first indication in metastatic triple-negative breast cancer back in 2020, and has since added urothelial cancer to the list. HR-positive HER2-negative breast cancer accounts for roughly 70% of new breast cancer cases worldwide per year, according to senior VP of oncology clinical development Bill Grossman, and many patients develop resistance to endocrine-based therapies or worsen on chemotherapy.

Raymond Stevens, Structure Therapeutics CEO

Be­hind Fri­day's $161M IPO: A star sci­en­tist, GPCR drug dis­cov­ery and a plan to chal­lenge phar­ma in di­a­betes

What does it take to pull off a $161 million biotech IPO these days?

In Structure Therapeutics’ case, it means having a star scientist co-founder paired with the computational drug discovery company Schrödinger, $198 million in private funding from blue-chip investors, almost six years of research work on G protein-coupled receptors and a slate of oral, small-molecule drugs, with an eye on the huge and growing diabetes and weight-loss market.

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Te­va drops out of in­dus­try trade group PhRMA

Following in AbbVie’s footsteps, Teva confirmed on Friday that it’s dropping out of the industry trade group Pharmaceutical Research and Manufacturers of America (PhRMA).

Teva didn’t give a reason for its decision to leave, saying only in a statement to Endpoints News that it annually reviews “effectiveness and value of engagements, consultants and memberships to ensure our investments are properly seated.”

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Sanofi CFO Jean-Baptiste de Chatillon (L) and CEO Paul Hudson (Romuald Meigneux/Sipa via AP Images)

Sanofi sees downtick in flu sales as it preps for launch of RSV an­ti­body

Sanofi expects its RSV antibody jointly developed with AstraZeneca will be available next season, executive VP of vaccines Thomas Triomphe announced on the company’s quarterly call.

Beyfortus, also known as nirsevimab, was approved in the EU back in November and is currently under FDA review with an expected decision coming in the third quarter of this year. The news comes as the FDA plans to hold advisory committee meetings over the next couple months to review RSV vaccines from Pfizer and GSK.

Christophe Weber, Takeda CEO (Photographer: Shoko Takayasu/Bloomberg via Getty Images)

Take­da fo­cus­es on ‘di­verse’ pipeline prospects on heels of two ac­qui­si­tions

After a whopping $4 billion asset buy from Nimbus Therapeutics, along with a $400 million deal with Hutchmed for a colorectal cancer drug, Takeda executives touted pipeline optimism on its latest earnings call this week.

That’s because the TYK2 inhibitor for psoriasis Takeda is getting from Nimbus, along with the Hutchmed fruquintinib commercialization outside of China, are just two of what it reports are 10 late-stage development programs of promising candidates.

Regeneron CSO George Yancopoulos (L) and CEO Len Schleifer at a groundbreaking for its new Tarrytown, NY facility, June 2022 (Lev Radin/Pacific Press/LightRocket via Getty Images)

In show­down with Roche, Re­gen­eron gears up for po­ten­tial Eylea ex­pan­sion amid Covid de­cline

Regeneron faced a substantial slump in overall revenue last year, but the focus still remains on some of its biggest blockbusters.

The pharma with several high-profile partnerships — Sanofi and Bayer among them — said Friday that Q4 revenue was down 31% for the quarter, and down 24% for the entire year. However, that won’t stop blockbuster expansion plans.

One of those is Eylea, the Bayer-partnered eye disease drug that has been in major competition with Roche’s Vabysmo. While Eylea is currently only approved in a 2 mg dose, the company recently filed for approval to give a 8 mg dose, in hopes of making a longer-lasting treatment.