Juan Andres, Moderna president, strategic partnerships and enterprise expansion

Ready for re­tire­ment, Juan An­dres is wav­ing good­bye to Mod­er­na in May

One of Mod­er­na’s tal­ents be­hind its rapid man­u­fac­tur­ing ramp-up dur­ing the Covid-19 pan­dem­ic will re­tire.

Juan An­dres, the com­pa­ny’s pres­i­dent of strate­gic part­ner­ships and en­ter­prise ex­pan­sion, will de­part Mod­er­na in May, CEO Stéphane Ban­cel said dur­ing the com­pa­ny’s fourth-quar­ter earn­ings call Thurs­day.

An­dres joined the biotech in 2017, ini­tial­ly head­ing up Mod­er­na’s man­u­fac­tur­ing op­er­a­tions be­fore be­com­ing chief tech­ni­cal op­er­a­tions and qual­i­ty of­fi­cer in 2020. Ban­cel said An­dres did a “his­toric job” with his team in 2020 and 2021 to scale Mod­er­na’s vac­cine man­u­fac­tur­ing dur­ing a pan­dem­ic.

“He led the team from hav­ing made, across our en­tire port­fo­lio, less than 100,000 dos­es in 2019 to more than 800 mil­lion dos­es in 2021,” Ban­cel said. “We and hun­dreds of mil­lions of peo­ple across the globe who re­ceived the Mod­er­na COVID-19 vac­cine owe Juan our grat­i­tude.”

An­dres has been fo­cused on build­ing out Mod­er­na’s ca­pa­bil­i­ties to sup­port its pipeline and lead­ing ef­forts to pro­duce a per­son­al­ized can­cer vac­cine, Ban­cel said. Af­ter his ex­it, his re­spon­si­bil­i­ties on the per­son­al­ized can­cer vac­cine will fall to pres­i­dent Stephen Hoge. Chief tech­ni­cal op­er­a­tions and qual­i­ty of­fi­cer Jerh Collins will be re­spon­si­ble for man­ag­ing the man­u­fac­tur­ing end of the Phase III tri­al and, even­tu­al­ly, the com­mer­cial re­lease.

An­dres was not im­me­di­ate­ly avail­able for an in­ter­view with End­points News.

Ac­cord­ing to An­dres’ LinkedIn pro­file, he has worked in man­u­fac­tur­ing for most of his ca­reer, start­ing with Eli Lil­ly, cul­mi­nat­ing in his role as VP of man­u­fac­tur­ing. He moved to No­var­tis in 2005, even­tu­al­ly be­com­ing glob­al head of tech­ni­cal op­er­a­tions, and was re­spon­si­ble for all as­pects of man­u­fac­tur­ing and the sup­ply chain for the com­pa­ny’s phar­ma di­vi­sion.

Ed­i­tor’s note: This sto­ry has been cor­rect­ed to re­move an in­cor­rect ref­er­ence to Ban­cel, and re­place it with An­dres. 

Image courtesy of The Janssen Pharmaceutical Companies of Johnson & Johnson.

Pro­tect­ing the glob­al phar­ma­ceu­ti­cal in­no­va­tion ecosys­tem – what’s at stake?

We are living in a new era of healthcare that is rapidly advancing progress impacting patient outcomes and experiences. We’ve seen a remarkable pace of transformational innovation, applied research, and advanced clinical development over the last decade.

Despite this tremendous progress, there is much more work to be done, and patients are counting on us – now more than ever – to continue that momentum. At the heart of our industry is a focus on developing and delivering medicines for some of the world’s most challenging diseases, including those that have few or no effective treatments today.

Roger Perl­mut­ter lines up deals, fresh fund­ing at Eikon; Sec­ond RSV vac­cine ap­proved; Sev­er­al biotechs flash­ing red; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

As you come back to our website this weekend for ASCO news, don’t forget to check out our updated event lineup at BIO, which will cover everything from the current state of VC investing in biotech to top pharma R&D chiefs discussing how to make pipeline decisions.

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Bris­tol My­er­s' Op­di­vo keeps can­cer at bay in more lym­phoma pa­tients than Seagen's Ad­cetris in PhI­II: #AS­CO23

CHICAGO — In a study pitting Seagen’s Adcetris against Bristol Myers Squibb’s Opdivo in newly diagnosed patients with advanced classic Hodgkin lymphoma, a greater proportion of those who received Opdivo saw no cancer growth at one year compared to those who got Adcetris.

In addition, patients in the Opdivo arm of the Phase III trial reported reduced toxicities, according to lead investigator Alex Herrera, a hematologist-oncologist at City of Hope’s cancer cancer in Duarte, CA. Notably, the trial included more than 200 children across both arms. Generally, more than half of children with advanced Hodgkin lymphoma receive radiation therapy, but in this trial, dubbed SWOG S1826, only a handful of patients in the two arms received radiotherapy, sparing many children from long-term side effects of radiation.

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Catal­ent makes ad­di­tion­al lay­offs at In­di­ana fa­cil­i­ty

Contract manufacturer Catalent is making more staff cuts at one of its locations in the US amid dramatic corrective actions it’s been taking over the past few months.

In an email to Endpoints News, a Catalent spokesperson confirmed the company is making “a number of personnel changes” at a manufacturing facility in Bloomington, IN. While a specific number was not given to Endpoints, several local media outlets, including Indiana Public Media and the Bloomington Herald-Times, have put the number of layoffs at 150. No postings have been made to the Indiana Department of Workforce Development’s WARN notice.

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Full TIG­IT da­ta from Gilead, Ar­cus show low­er PFS rates than De­cem­ber read­out: #AS­CO23

CHICAGO — Gilead and Arcus unveiled a fuller snapshot of a Phase II study testing their experimental cancer immunotherapy combo that showed lower progression-free survival rates than its previous update, results that are likely to spark further debate over the closely-watched clinical trial.

Last December, the anti-TIGIT/anti-PD-L1 combo, positioned as a first-line treatment for non-small cell lung cancer, recorded data that drew mixed reactions. The latest analysis, presented Saturday afternoon at ASCO, included only a handful more patients than the previous update, but PFS rates fell — in one cohort by nearly three months.

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Servi­er’s vo­rasi­denib stalls pro­gres­sion of brain can­cer by 61% in piv­otal PhI­II IN­DI­GO study: #AS­CO23

An experimental pill from Servier Pharmaceuticals showed potentially practice-changing results in a narrow group of brain cancer patients, cutting the risk of their cancers progressing by 61%, according to a late-stage clinical trial.

The drug, vorasidenib, is a precision medicine that only works in certain people whose cancer carries mutations in one of two genes called IDH1/2. Doctors hope that the therapy will delay the need for chemotherapy or radiation, which are often used to combat relapses in patients who’ve previously undergone surgery to remove brain tumors.

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Stephen MacMillan, Hologic CEO (Photo by Riccardo Savi/Getty Images for Concordia Summit)

Il­lu­mi­na names Ho­log­ic CEO as new board mem­ber and chair

Illumina’s board appointed two new members, including Hologic CEO Stephen MacMillan as the non-executive chair, a move that followed a proxy fight that saw shareholders oust the company’s board chair.

The DNA sequencing company also appointed Scott Ullem, the CFO of Edwards Lifesciences, to the board, according to a company statement.

Illumina’s plans to add two new board members came as Carl Icahn waged a board proxy campaign culminating with shareholders electing his candidate, Andrew Teno, over board chair John Thompson. Illumina CEO Francis deSouza survived a threat to his board seat by securing more than twice the shareholder votes than his challenger. Another Illumina candidate, Robert Epstein, was also elected and remained on the board.

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Take­da ax­es gene ther­a­py deal with Po­sei­da Ther­a­peu­tics amid broad­er re­think

Less than two years after Takeda inked a collaboration with Poseida Therapeutics to develop six liver-directed and hematopoietic stem cell-directed in vivo gene therapies, Takeda will end the partnership on July 30, the company confirmed to Endpoints News.

The breakup is not unexpected, coming on the heels of Takeda’s April announcement that it planned to stop discovery and preclinical work in AAV gene therapy, as well as research and preclinical work on rare hematology. A representative for Takeda confirmed that the partnership ended because of the company’s decision to stop that work.

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Roche plans to di­vest from lega­cy Genen­tech man­u­fac­tur­ing fa­cil­i­ty in Cal­i­for­nia

Roche is planning to make some changes to its subsidiary’s manufacturing network in California.

The Swiss pharma announced Wednesday that it plans to divest from Genentech’s manufacturing facility in Vacaville, CA, around 58 miles northeast of San Francisco. According to a statement from Roche, the move is part of a “broader strategy” to bring its manufacturing capabilities in line with its future pipeline. Roche is starting the process of finding a buyer for the site but has not named any candidates yet.

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