A sweeping form of search-and-replace editing has come for mRNA
For several years now, biotechs have enthused over DNA-altering technologies that allow the editing of any genetic sequence by swapping out defective or unwanted code for a new one. Now, a handful of startups and academic groups are working on a similar approach for short-lived mRNA molecules.
The goal is to combine the benefits of large-block edits with the more versatile, less permanent and potentially safer target of mRNA. While the new technologies go by many names, scientists familiar with the work told Endpoints News that the techniques were inspired by the conceptually analogous prime editing. Some call it RNA writing.
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