Roche Chi­na CEO preps for a move to Mer­ck KGaA while US Mer­ck adds to C-suite; Suc­ces­sion plan fi­nal­ized for EVPs re­tir­ing from Sanofi

Hong Chow

→ Be­gin­ning Oct. 1, Roche Chi­na CEO Hong Chow will be head of Chi­na & in­ter­na­tion­al for Mer­ck KGaA’s health­care busi­ness, a po­si­tion that al­so en­com­pass­es Japan, Eu­rope, Latin Amer­i­ca, Asia-Pa­cif­ic, the Mid­dle East, Africa and Rus­sia. The mul­ti-pronged po­si­tion al­so has Chow lead­ing the car­dio­vas­cu­lar me­tab­o­lism & en­docrinol­o­gy fran­chise and the Glob­al Busi­ness In­no­va­tion (GBI) unit. A Bay­er alum, Chow has helmed Roche Chi­na since 2015.

“My years with Roche have been just in­cred­i­ble and I am for­ev­er grate­ful for the op­por­tu­ni­ty to work with so many amaz­ing peo­ple in Chi­na and around the world to de­liv­er so many more in­no­v­a­tive drugs to Chi­nese pa­tients in an unimag­in­able speed,” Chow said on LinkedIn. “At the same time, I am very ex­cit­ed to start the new chap­ter in Oc­to­ber with Mer­ck to make a broad­er im­pact to pa­tients and so­ci­ety in Chi­na and in­ter­na­tion­al­ly.”

Cristal Down­ing

→ As for the oth­er Mer­ck, Cristal Down­ing will be­come chief com­mu­ni­ca­tions & pub­lic af­fairs of­fi­cer for new CEO Rob Davis’ team, ef­fec­tive Aug. 16. Down­ing jumps from an­oth­er Big Phar­ma, J&J, where she spent six years in mul­ti­ple com­mu­ni­ca­tions ca­pac­i­ties, end­ing her run there as VP, com­mu­ni­ca­tion & pub­lic af­fairs, med­ical de­vices. Mer­ck’s lead­er­ship re­vamp has ex­tend­ed be­yond the CEO slot, with Car­o­line Litch­field suc­ceed­ing Davis as CFO, for­mer chief mar­ket­ing of­fi­cer Mike Nal­ly leav­ing for Flag­ship’s Gen­er­ate Bio­med­i­cines, and Dean Li tak­ing over R&D for Roger Perl­mut­ter, who’s get­ting a fresh start as CEO of Eikon Ther­a­peu­tics.

Karen Line­han

→ Long­time ex­ecs Karen Line­han (EVP, gen­er­al coun­sel and head of le­gal, ethics & busi­ness in­tegri­ty) and Philippe Lus­can (EVP, glob­al head of in­dus­tri­al af­fairs) are re­tir­ing from Sanofi, with Roy Pa­p­atheodor­ou and Bren­dan O’Callaghan slat­ed to re­place them. Pa­p­atheodor­ou has been gen­er­al coun­sel at No­var­tis since 2017 and joined the Swiss phar­ma in 2014. O’Callaghan scores a pro­mo­tion from his cur­rent po­si­tion as glob­al head of Sanofi’s bi­o­log­ics plat­form that will take ef­fect af­ter Lus­can’s re­tire­ment some­time in 2022. Their pre­de­ces­sors share an im­pres­sive run: Lus­can’s Sanofi ca­reer be­gan in 1990, while Line­han, who re­tires on Dec. 31, joined soon af­ter in 1991.

Lu­ciana Bo­rio has quite the dec­o­rat­ed ré­sumé and she’s adding a new gig as a ven­ture part­ner at Bob Nelsen’s ARCH to the list. Bo­rio, who was once vet­ted by Pres­i­dent Biden’s team to lead the FDA as com­mis­sion­er, for­mer­ly served as the ad­min­is­tra­tion’s act­ing chief sci­en­tist. In ad­di­tion, she’s held roles as VP at non­prof­it in­vest­ment firm In-Q-Tel, serves as a se­nior fel­low for glob­al health at the Coun­cil on For­eign Re­la­tions, and is a mem­ber of CEPI’s sci­en­tif­ic ad­vi­so­ry com­mit­tee.

Bruce Eaton

Jim Mullen is fill­ing an­oth­er C-suite va­can­cy at Ed­i­tas Med­i­cine by pro­mot­ing Bruce Eaton to CBO af­ter choos­ing Mark Shear­man to re­place Charles Al­bright as CSO. Eaton’s as­so­ci­a­tion with Ed­i­tas dates back to 2015 when he start­ed con­sult­ing for the genome edit­ing play­er, then be­came a re­search col­lab­o­ra­tor be­fore ul­ti­mate­ly gain­ing the ti­tle of SVP, chem­istry, and site head in Boul­der, CO. Eaton al­so co-found­ed and was CEO of i2 Phar­ma­ceu­ti­cals and fleet­ing­ly served as COO of So­ma­Log­ic.

On a re­lat­ed Ed­i­tas note, for­mer CEO Cyn­thia Collins has been elect­ed to the board of di­rec­tors at Po­sei­da Ther­a­peu­tics.

→ Or­chard Ther­a­peu­tics’ for­mer chief tech­ni­cal of­fi­cer, Ran Zheng, is tak­ing over the wheel at Land­mark Bio — a new cen­ter for ad­vanced cell man­u­fac­tur­ing once known as the Cen­ter for Ad­vanced Bi­o­log­i­cal In­no­va­tion and Man­u­fac­tur­ing (CABIM). Dur­ing her time at Or­chard, Zheng was ad­vanc­ing the com­pa­ny’s prod­uct pipeline with the ap­proval of Lib­meldy for metachro­mat­ic leukody­s­tro­phy. Be­sides her stint at Or­chard, Zheng held lead­er­ship po­si­tions at Gen­zyme and Am­gen.

Medicxi-backed Syn­Ox Ther­a­peu­tics launched in No­vem­ber 2020 with a $44 mil­lion Se­ries A round, aim­ing to de­vel­op an an­ti­body to treat tenosyn­ovial gi­ant cell tu­mors (TGCT) named emac­tuzum­ab that John Reed once had on his radar while he was with Roche. This week Ray Bar­low takes over as CEO of Syn­Ox, while Ton Logten­berg has been named chair­man. Bar­low was CBO of Kiadis Phar­ma, the Dutch biotech which was sold to Sanofi — where Reed now leads R&D — for $357 mil­lion. He took on a num­ber of busi­ness de­vel­op­ment roles at As­traZeneca and was Am­gen’s ex­ec­u­tive di­rec­tor of cor­po­rate de­vel­op­ment from 2012-17. In ad­di­tion to start­ing Cru­cell (ac­quired by J&J), Logten­berg found­ed Merus and stepped down as the com­pa­ny’s pres­i­dent, CEO and prin­ci­pal fi­nan­cial of­fi­cer at the end of 2019.

Kris­ten Al­bright

→ Lon­don-based mi­cro­bial im­munother­a­py out­fit Prokar­i­um has pro­mot­ed Kris­ten Al­bright to CEO. Al­bright, who set her ca­reer in mo­tion as a post­doc­tor­al fel­low at J&J, first turned up at Prokar­i­um in 2018 as VP, busi­ness de­vel­op­ment & trans­la­tion­al re­search, then got the bump to COO last sum­mer. Al­bright has al­so been a busi­ness de­vel­op­ment and li­cens­ing man­ag­er with Emer­gent BioSo­lu­tions. That isn’t the on­ly C-suite news here: Prokar­i­um has en­list­ed Uz Stamm­berg­er as CMO, for­mer­ly the trans­la­tion­al clin­i­cal on­col­o­gy pro­gram leader at the No­var­tis In­sti­tutes for Bio­Med­ical Re­search and the clin­i­cal lead for tepo­tinib at Mer­ck KGaA.

Jude Samul­s­ki

→ It’s go big or go home with the re­in­force­ments at Se­lec­ta Bio­sciences, ap­point­ing AAV trail­blaz­er Jude Samul­s­ki as a gene ther­a­py spe­cial ad­vi­sor. What’s the con­nec­tion here? Play­ing a quick Six De­grees of Jude Samul­s­ki game, he co-found­ed and is CSO at AskBio, which made a splash by bring­ing in pres­i­dent of ther­a­peu­tics Kathy High, who co-found­ed Spark, which has col­lab­o­rat­ed on gene ther­a­pies with … Se­lec­ta Bio­sciences.

James Cas­sidy

Pfiz­er spin­out Spring­Works Ther­a­peu­tics adds to its long line of new ex­ecs with CMO James Cas­sidy. While he was with Len Schleifer’s squad at Re­gen­eron, Cas­sidy was VP of on­col­o­gy/strate­gic pro­gram di­rec­tion, and he’s al­so been VP of on­col­o­gy at Bris­tol My­ers Squibb. In De­cem­ber 2020, Spring­Works pro­mot­ed Badred­din Edris to COO and Mary Smith to chief de­vel­op­ment of­fi­cer, then plucked chief com­mer­cial of­fi­cer Bhavesh Ashar from Bay­er in March. Spring­Works sub­se­quent­ly brought in R&D chief Mike Burgess from Turn­stone Bi­o­log­ics in May.

Pe­ter Buh­ler

→ French vac­cine biotech Val­ne­va has fi­nal­ly found a re­place­ment for CFO David Lawrence, but they’re stretch­ing out the tran­si­tion by in­di­cat­ing that Pe­ter Buh­ler’s first day will be some­time “with­in the six months.” This odyssey to­ward a new CFO be­gan when Lawrence ini­tial­ly re­tired from Val­ne­va in Sep­tem­ber 2020, on­ly to be named act­ing CFO sev­er­al months lat­er. Now he’ll “con­tin­ue sup­port­ing Val­ne­va un­til late 2021” in a change to the orig­i­nal plan up­on re­tire­ment to stick around as an ad­vi­sor un­til ear­ly 2021. Buh­ler, the cur­rent CFO of Quo­tient, has a num­ber of fi­nan­cial roles on his ré­sumé, in­clud­ing head of fi­nance, Eu­rope at Mer­ck Serono.

→ The next wave of new lead­er­ship at Pe­ter Thiel-backed Pep­ti­log­ics fea­tures a quin­tet of ex­ecs, with CBO Nik Bhide lead­ing off. A No­var­tis and Al­ler­gan vet in fi­nance and cor­po­rate de­vel­op­ment, Bhide joins the pep­tide drug de­vel­op­er af­ter a stint as the ex­ec­u­tive di­rec­tor, busi­ness de­vel­op­ment & li­cens­ing for Mer­ck Re­search Lab­o­ra­to­ries.

Marc Lesnick (SVP, reg­u­la­to­ry and qual­i­ty) co-found­ed and was chief de­vel­op­ment of­fi­cer at Park Ther­a­peu­tics, and his reg­u­la­to­ry knowhow has tak­en him to such com­pa­nies as Sh­iono­gi, Cas­ca­di­an Ther­a­peu­tics and Spruce Ther­a­peu­tics. Jodie Gillon (SVP, cor­po­rate af­fairs and pa­tient ad­vo­ca­cy) is a Big Phar­ma alum who was re­cent­ly Abeona’s chief pa­tient of­fi­cer and head of cor­po­rate and med­ical af­fairs. Al­so new to Pitts­burgh-based Pep­ti­log­ics is Al­bert Fonti­ciel­la (VP of peo­ple), who has worked in the Steel City as VP of cor­po­rate ser­vices for Ed­wards Marc Brands, the choco­lati­er which al­so has The Milk Shake Fac­to­ry and Snap­pers pret­zel snacks with­in its um­brel­la. And Shire vet Steve Kulp (VP of op­er­a­tions) moves on from his cor­po­rate op­er­a­tions gig at Idera Phar­ma­ceu­ti­cals.

Thiel con­tributed to the $35.4 mil­lion Se­ries B that Pep­ti­log­ics an­nounced this past De­cem­ber be­fore Christ­mas.

Lisa Danzig

→ The pieces to the lead­er­ship puz­zle at CRISPR play­er Ex­ci­sion Bio­Ther­a­peu­tics — built around the work of Kamel Khalili — con­tin­ue to fit in­to place with Lisa Danzig tak­ing the CMO reins. Danzig’s lead­er­ship on Ch­i­ron’s clin­i­cal meningo­coc­cal fran­chise team laid the ground­work for her ca­reer; she has held the CMO po­si­tion at Pax­Vax and was glob­al head of med­ical & sci­en­tif­ic af­fairs at No­var­tis. Since its Se­ries A, Ex­ci­sion has al­so ap­point­ed an SVP of clin­i­cal de­vel­op­ment, a CFO and a head of trans­la­tion­al med­i­cine.

→ An­ti-ag­ing play­er Alka­h­est, now a Gri­fols sub­sidiary af­ter a $146 mil­lion deal in Sep­tem­ber 2020, has pegged Am­gen vet César Cere­zo as CMO. Cere­zo piv­ots to Alka­h­est af­ter four years with the phar­ma gi­ant, which just chan­neled Mon­ty Hall again this week and made a deal to ac­quire Teneo­bio for $2.5 bil­lion. For the last year, Cere­zo was Am­gen’s VP, ther­a­peu­tic area head of glob­al af­fairs, gen­er­al med­i­cine in the fol­low­ing ther­a­peu­tic ar­eas: car­dio­vas­cu­lar/meta­bol­ic, bone, nephrol­o­gy, neu­ro­science, in­flam­ma­tion and biosim­i­lars.

Dan­nielle Ap­pel­hans

Dan­nielle Ap­pel­hans has been named COO at Pablo Cagnoni’s Ru­bius Ther­a­peu­tics, which saw its stock soar due to the mid-March re­lease of hu­man da­ta for its red blood cell-de­rived can­cer drug. Ap­pel­hans, an ex-team leader in phar­ma­ceu­ti­cal man­u­fac­tur­ing at Eli Lil­ly, was pre­vi­ous­ly SVP of tech­ni­cal op­er­a­tions and chief tech­ni­cal of­fi­cer for No­var­tis Gene Ther­a­pies. Ru­bius’ shares have since lev­eled off and the biotech is pin­ning its hopes on RTX-240 af­ter “de­pri­or­i­tiz­ing” its lead drug RTX-134 in March 2020.

RARE-X has tapped Char­lene Son Rig­by to helm its com­pa­ny as CEO of the rare dis­ease tech­nol­o­gy non­prof­it. Son Rig­by pre­vi­ous­ly served in po­si­tions at Or­a­cle and Dou­bletwist be­fore hop­ping over to the CBO role at Fab­ric Ge­nomics. Ad­di­tion­al­ly, Nicole Boice, RARE-X’s founder and cur­rent ex­ec­u­tive di­rec­tor, will shift over to the role of chief en­gage­ment of­fi­cer.

→ Fresh off its $40 mil­lion Se­ries A, Stephen Squin­to-led Gen­nao Bio has brought on Clau­dine Prowse as CFO af­ter the biotech an­nounced the ad­di­tion of COO Chris Duke a cou­ple weeks ago. Prowse wraps up her time at Rock­et Phar­ma­ceu­ti­cals (which pre­dates the In­otek merg­er) as SVP, strat­e­gy and cor­po­rate de­vel­op­ment, and she’s been an in­vestor re­la­tions ex­ec with Bio­gen and Hu­man Genome Sci­ences.

Sung You

→ Our Max Gel­man pro­filed Sali­o­Gen when it an­nounced its Se­ries A fi­nanc­ing in March, look­ing to play an in­te­gral part in gene ther­a­py 3.0 by us­ing mam­malian-de­rived en­zymes as its de­liv­ery sys­tem. This week Sali­o­Gen is as­sem­bling more mem­bers of the team with Sung You, chief busi­ness and strat­e­gy of­fi­cer; Nan­cy Craig, SVP of ge­net­ic en­gi­neer­ing and mo­bile el­e­ments; and Sandeep Ne­ma, SVP of tech­ni­cal op­er­a­tions. Be­fore be­com­ing a man­ag­ing part­ner with PBM Cap­i­tal, You was a health­care in­vest­ment bank­ing ex­ec with Mor­gan Stan­ley; Craig’s work in mo­bile ge­net­ic el­e­ments is the dri­ving force be­hind Sali­o­Gen’s gene cod­ing plat­form called ED­IT; and Ne­ma ends a 24-year as­so­ci­a­tion with Pfiz­er, mak­ing his ex­it as ex­ec­u­tive di­rec­tor of bio­ther­a­peu­tics phar­ma­ceu­ti­cal sci­ence.

→ When mi­Ra­gen bought out Virid­i­an last fall — tak­ing the Virid­i­an name with it — Jonathan Vi­o­lin was cho­sen to con­duct the Boul­der, CO biotech or­ches­tra and Bar­rett Katz land­ed the CMO slot. This week Virid­i­an has an­oth­er prin­ci­pal mu­si­cian to add with CFO and CBO Kris­t­ian Humer com­ing on board. Humer had been with Cit­i­group for 11 years, and since 2016 he was man­ag­ing di­rec­tor of bank­ing, cap­i­tal mar­kets & ad­vi­so­ry for Citi’s glob­al health­care team.

Tracey Lodie

→ Treg-fo­cused Quell Ther­a­peu­tics has pulled in Tracey Lodie as CSO, fol­low­ing a stint at Gami­da Cell where she served in the same role. Pri­or to that, she was SVP, tran­si­tion­al im­munol­o­gy at Blue­Rock Ther­a­peu­tics and VP of im­munol­o­gy at Sy­ros Phar­ma­ceu­ti­cals. Lodie jump-start­ed her ca­reer at Sanofi Gen­zyme.

→ With first-year CEO An­drin Os­wald at the con­trols, Cen­to­gene has tapped Patrice Denèfle as CSO start­ing Aug. 16. Denèfle picks up the man­tle from Phil Lam­bert, who’s leav­ing the Ger­man rare dis­ease biotech for undis­closed rea­sons af­ter less than two years on the job. Once the gen­er­al man­ag­er of the Roche In­sti­tute for Re­search and Trans­la­tion­al Med­i­cine, Denèfle has been a chief sci­en­tist be­fore with 4P-Phar­ma and Genethon.

Si­mon Harnest

Si­mon Harnest has an­swered the call to be chief in­vest­ment of­fi­cer at Emeryville, CA-based Metageno­mi, the gene edit­ing biotech that de­buted with a Se­ries A that Leaps by Bay­er co-led in No­vem­ber. When he first clocked in at Cel­lec­tis at 2015, Harnest was VP, fi­nance and in­vestor re­la­tions, and he leaves An­dré Chouli­ka’s team af­ter be­ing pro­mot­ed to chief in­vest­ment of­fi­cer this Jan­u­ary.

Bruce Ker­win

→ The cash spig­ot is flow­ing at Peer Re­view main­stay Umo­ja Bio­phar­ma af­ter its $210 mil­lion Se­ries B in June, and the Seat­tle-based com­pa­ny con­tin­ues its tor­rid hir­ing pace with three new ex­ecs. Bruce Ker­win (SVP of process and prod­uct de­vel­op­ment) was VP of drug prod­uct de­sign at Just Bio­ther­a­peu­tics — al­so out of Seat­tle — and served as a sci­en­tif­ic di­rec­tor in pro­tein for­mu­la­tion de­vel­op­ment at Am­gen, where he spent 16 years. Ryan Lar­son (VP and head of trans­la­tion­al sci­ence) co-found­ed the cell ther­a­py prod­uct sci­ences de­part­ment at Bris­tol My­ers and was se­nior di­rec­tor of the cell ther­a­py prod­uct and an­a­lyt­i­cal team. Fi­nal­ly, Mike Fitz­patrick (VP of busi­ness de­vel­op­ment and op­er­a­tions) is al­so a Bris­tol My­ers vet — spend­ing 15 years at Zy­mo­Ge­net­ics be­fore the 2010 buy­out — with re­spon­si­bil­i­ties rang­ing from pro­tein bio­chem­istry and process de­vel­op­ment to cor­po­rate op­er­a­tions.

Metri­on Bio­sciences has re­cruit­ed Nick Fos­ter as CCO and head of glob­al busi­ness de­vel­op­ment. Fos­ter joins with ex­pe­ri­ence from his times at Bio­Fo­cus (now Charles Riv­er Lab­o­ra­to­ries) as as­so­ciate di­rec­tor, busi­ness de­vel­op­ment Eu­rope; Optib­ri­um as head of com­mer­cial op­er­a­tions; and WuXi AppTec as di­rec­tor, busi­ness de­vl­op­ment.

Anand Shah

Mak­ing its plans to go pub­lic last week, Till­man Gern­gross and Ada­gio Ther­a­peu­tics are build­ing a blue-rib­bon group for its board of di­rec­tors, with Tom Hey­man, Anand Shah and Michael Wyz­ga re­serv­ing their seats along­side Ada­gio chair Rene Rus­so. Hey­man, the ex-pres­i­dent of John­son & John­son De­vel­op­ment Cor­po­ra­tion, re­tired in 2019 af­ter 37 years with J&J. Shah was deputy com­mis­sion­er for med­ical and sci­en­tif­ic af­fairs at the FDA for a year un­til he stepped aside in Jan­u­ary. And Wyz­ga, who was with Gen­zyme from 1993-2011 and was pres­i­dent and CEO of Ra­dius Health, is pres­i­dent of MSW Con­sult­ing, Inc.

Amy Garabe­di­an

→ Not shy­ing away from the IPO vol­cano that has erupt­ed the past cou­ple years, La­va Ther­a­peu­tics ex­ceed­ed $100 mil­lion with its raise in March and has wel­comed Amy Garabe­di­an this week as gen­er­al coun­sel and cor­po­rate sec­re­tary. Garabe­di­an had pre­vi­ous­ly been as­so­ciate gen­er­al coun­sel at Spark, where she had been lend­ing her le­gal ex­per­tise since 2015.

SPT Labtech has some changes in its lead­er­ship team. David New­ble, who has been serv­ing as man­ag­ing di­rec­tor has been tapped as the com­pa­ny’s CEO — tak­ing over for Patrick Ben­nett who will as­sume the role of chair­man of the board. Ad­di­tion­al­ly, Paul Ven­tu­ra has been named VP of sales and Jo­by Jenk­ins joins as VP of busi­ness de­vel­op­ment.

At­tralus has brought on Jake Bauer as an in­de­pen­dent di­rec­tor on its board of di­rec­tors. Bauer was most re­cent­ly CBO of MyoKar­dia and VP, busi­ness op­er­a­tions and head of cor­po­rate de­vel­op­ment at Ablex­is.

Adri­an Woolf­son

→ Af­ter Sang­amo’s R&D split last sum­mer, Adri­an Woolf­son has resur­faced as a board mem­ber at Im­munoScape, which ze­roes in on tech­nol­o­gy “that al­lows for im­mune pro­fil­ing and char­ac­ter­i­za­tion of the hu­man im­mune re­sponse at ex­treme­ly high res­o­lu­tion.” Ja­son Fontenot, the act­ing head of re­search af­ter Woolf­son’s de­par­ture, has since been pro­mot­ed to CSO, while Rob Schott came in to lead de­vel­op­ment at Sang­amo ear­li­er this year.

→ Siz­ing things up for an IPO ac­cord­ing to Bloomberg, Sin­ga­pore’s Hum­ming­bird Bio­science has beefed up its board of di­rec­tors with Fred Hutch pres­i­dent Tom Lynch. In May, Hum­ming­bird raised $125 mil­lion for its pre­ci­sion on­col­o­gy pipeline in a Se­ries C led by No­vo Hold­ings.

He­len Collins

Troy Wil­son-led Ku­ra On­col­o­gy has made He­len Collins a mem­ber of its board of di­rec­tors. The CMO at Five Prime un­til the Am­gen pur­chase, Collins has al­so been Gilead’s glob­al lead of on­col­o­gy biosim­i­lars.

→ Cam­bridge, MA im­muno-on­col­o­gy biotech On­corus has opened up a seat for Bar­bara Yan­ni on a board of di­rec­tors that has ex­pand­ed in the last year af­ter the ap­point­ments of Scott Canute and fel­low Mer­ck vet Er­ic Ru­bin. Yan­ni re­tired from Mer­ck in 2014 as VP and chief li­cens­ing of­fi­cer

Karimah Es Sabar

Lin­da Mar­bán and the folks at Capri­cor Ther­a­peu­tics are bring­ing in Karimah Es Sabar as a mem­ber of their board of di­rec­tors. Es Sabar is CEO and part­ner at Van­cou­ver-based Quark Ven­ture and she chairs the Health & Bio­sciences Eco­nom­ic Strat­e­gy Table for the gov­ern­ment of Cana­da.

→ Cell and gene ther­a­py biotech In­cep­tor Bio has named Mark Gilbert as chair of its sci­en­tif­ic ad­vi­so­ry board. Gilbert was the for­mer CMO of Juno Ther­a­peu­tics and was a fac­ul­ty mem­ber at Fred Hutch and the Uni­ver­si­ty of Wash­ing­ton in Seat­tle.

Janssen vet Mark Bach has gained a seat on the clin­i­cal sci­en­tif­ic ad­vi­so­ry board at Lu­mos Phar­ma. Bach is cur­rent­ly CMO for ShouTi, hav­ing joined the com­pa­ny from As­cendis Phar­ma.

Health­care Dis­par­i­ties and Sick­le Cell Dis­ease

In the complicated U.S. healthcare system, navigating a serious illness such as cancer or heart disease can be remarkably challenging for patients and caregivers. When that illness is classified as a rare disease, those challenges can become even more acute. And when that rare disease occurs in a population that experiences health disparities, such as people with sickle cell disease (SCD) who are primarily Black and Latino, challenges can become almost insurmountable.

David Meek, new Mirati CEO (Marlene Awaad/Bloomberg via Getty Images)

Fresh off Fer­Gene's melt­down, David Meek takes over at Mi­rati with lead KRAS drug rac­ing to an ap­proval

In the insular world of biotech, a spectacular failure can sometimes stay on any executive’s record for a long time. But for David Meek, the man at the helm of FerGene’s recent implosion, two questionable exits made way for what could be an excellent rebound.

Meek, most recently FerGene’s CEO and a past head at Ipsen, has become CEO at Mirati Therapeutics, taking the reins from founding CEO Charles Baum, who will step over into the role of president and head of R&D, according to a release.

Dave Lennon, former president of Novartis Gene Therapies

Zol­gens­ma patent spat brews be­tween No­var­tis and Re­genxbio as top No­var­tis gene ther­a­py ex­ec de­parts

Regenxbio, a small licensor of gene therapy viral vectors spun out from the University of Pennsylvania, is now finding itself in the middle of some major league patent fights.

In addition to a patent suit with Sarepta Therapeutics from last September, Novartis, is now trying to push its smaller partner out of the way. The Swiss biopharma licensed Regenxbio’s AAV9 vector for its $2.1 million spinal muscular atrophy therapy Zolgensma.

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Volker Wagner (L) and Jeff Legos

As Bay­er, No­var­tis stack up their ra­dio­phar­ma­ceu­ti­cal da­ta at #ES­MO21, a key de­bate takes shape

Ten years ago, a small Norwegian biotech by the name of Algeta showed up at ESMO — then the European Multidisciplinary Cancer Conference 2011 — and declared that its Bayer-partnered targeted radionuclide therapy, radium-223 chloride, boosted the overall survival of castration-resistant prostate cancer patients with symptomatic bone metastases.

In a Phase III study dubbed ALSYMPCA, patients who were treated with radium-223 chloride lived a median of 14 months compared to 11.2 months. The FDA would stamp an approval on it based on those data two years later, after Bayer snapped up Algeta and christened the drug Xofigo.

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Ex­elix­is pulls a sur­prise win in thy­roid can­cer just days ahead of fi­nal Cabome­tyx read­out

Exelixis added a thyroid cancer indication to its super-seller Cabometyx’s label on Friday — months before the FDA was expected to make a decision, and days before the company was set to unveil the final data at #ESMO21.

At a median follow-up of 10.1 months, differentiated thyroid cancer patients treated with Cabometyx (cabozantinib) lived a median of 11 months without their disease worsening, compared to just 1.9 months for patients given a placebo, Exelixis said on Monday.

Rafaèle Tordjman (Jeito Capital)

Con­ti­nu­ity and di­ver­si­ty: Rafaèle Tord­j­man's women-led VC firm tops out first fund at $630M

For a first-time fund, Jeito Capital talks a lot about continuity.

Rafaèle Tordjman had spotlighted that concept ever since she started building the firm in 2018, promising to go the extra mile(s) with biotech entrepreneurs while pushing them to reach patients faster.

Coincidentally, the lack of continuity was one of the sore spots listed in a report about the European healthcare sector published that same year by the European Investment Bank — whose fund is one of the LPs, alongside the American pension fund Teacher Retirement System of Texas and Singapore’s Temasek, to help Jeito close its first fund at $630 million (€534 million). As previously reported, Sanofi had chimed in €50 million, marking its first investment in a French life sciences fund.

Mi­rati tri­umphs again in KRAS-mu­tat­ed lung can­cer with a close­ly watched FDA fil­ing now in the cards

After a busy weekend at #ESMO21, which included a big readout for its KRAS drug adagrasib in colon cancer, Mirati Therapeutics is ready to keep the pressure on competitor Amgen with lung cancer data that will undergird an upcoming filing.

In topline results from a Phase II cohort of its KRYSTAL-1 study, adagrasib posted a response rate of 43% in second-line-or-later patients with metastatic non-small cell lung cancer containing a KRAS-G12C mutation, Mirati said Monday.

Den­mark's Gubra to col­lab­o­rate with Bay­er on pep­tides; Sam­sung and Bio­gen re­ceive FDA ap­proval for Lu­cen­tis biosim­i­lar

Danish biotech Gubra announced a research collaboration and license agreement with Bayer to develop peptide therapeutics to treat cardiorenal diseases. The collaboration will utilize Gubra’s peptide drug discovery platform to identify potential candidates.

This is not the first time Gubra has partnered with a company on peptide therapeutics — they partnered with Boehringer Ingelheim back in 2017 to create peptide therapeutics to treat obesity.

Ex-My­lan em­ploy­ee pleads guilty to in­sid­er trad­ing, il­le­gal­ly deal­ing on FDA ap­provals, earn­ings and Up­john merg­er

A former Mylan IT executive pleaded guilty Friday to an insider trading scheme where he bought and sold stock options on another executive’s advice.

Prosecutors secured the plea from Dayakar Mallu, Mylan’s former VP of global operations information technology, after uncovering the plan. Mallu collaborated with an unnamed “senior manager,” the SEC said, to trade options ahead of Mylan public announcements regarding FDA approvals, revenue reports and its merger with the Pfizer generics subsidiary Upjohn. The two subsequently shared profits.

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