Updated: Roche pays Alnylam $310M cash to partner on RNAi candidate for heart disease
Roche is buying into a mid-stage cardiovascular drug candidate out of Alnylam’s RNAi platform in a deal that starts with $310 million upfront and could add up to $2.8 billion.
The two companies will co-develop and co-commercialize the program, zilebesiran, as a treatment of hypertension in patients with high cardiovascular risk and other heart diseases by lowering blood pressure.
In the US, the duo will split profits and losses equally, while Roche will take on ex-US sales and pay Alnylam a royalty in those regions. It also agreed to shoulder 60% of the development costs for the first indication, which will include an expensive cardiovascular outcomes trial prior to filing for approval. Alnylam will lead that joint effort.
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