Samantha Truex, Upstream Bio CEO

Saman­tha Truex of­fi­cial­ly un­wraps Up­stream Bio, her se­cre­tive, Or­biMed-backed biotech with $200M in the bank

Af­ter Saman­tha Truex shut down Quench Bio ear­ly last year, she knew she want­ed to get back in­to the biotech world and run an­oth­er com­pa­ny. The path just end­ed up more wind­ing than ini­tial­ly ex­pect­ed.

Truex had joined At­las Ven­tures a cou­ple months af­ter Quench closed up shop, and the wheels were in mo­tion for her to run an At­las-backed com­pa­ny late last year, as End­points News pre­vi­ous­ly re­port­ed in Feb­ru­ary. But she soon de­cid­ed to change course and joined an Or­biMed-fund­ed biotech still in stealth, one that had raised $200 mil­lion, with records list­ing her as CEO as ear­ly as Nov. 30, 2021.

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