Sarep­ta snags its part­ner's CSO, Louise Rodi­no-Kla­pac, to lead new gene ther­a­py unit

Putting one more ar­row in its mus­cu­lar dy­s­tro­phy quiver, Sarep­ta has snagged a top ex­ec­u­tive from one of its part­ners to lead the com­pa­ny’s new­ly-cre­at­ed gene ther­a­py unit. Louise Rodi­no-Kla­pac is com­ing on board as vice pres­i­dent of gene ther­a­py.

Rodi­no-Kla­pac is com­ing from Sarep­ta’s part­ner Na­tion­wide Chil­dren’s Hos­pi­tal, where she was head­ing up the lab­o­ra­to­ry for gene ther­a­py re­search for mus­cu­lar dy­s­tro­phies. Her work has in­volved 11 in­ves­ti­ga­tion­al new gene ther­a­py drugs, and six that have reached hu­man tri­als. Sarep­ta is part­nered with the hos­pi­tal on a mi­cro-dy­s­trophin Duchenne gene ther­a­py that got IND clear­ance last No­vem­ber.

Doug In­gram

But Rodi­no-Kla­pac al­so has ties to an­oth­er Sarep­ta part­ner — she’s CSO of My­onexus, the com­pa­ny Sarep­ta li­censed five gene ther­a­pies from ear­li­er this month. The deal al­lowed Sarep­ta to edge in­to Limb-gir­dle mus­cu­lar dy­s­tro­phies, pay­ing My­onexus $60 mil­lion up­front with $45 mil­lion in po­ten­tial mile­stones — and snar­ing a buy­out op­tion at proof-of-con­cept.

She’s keep­ing her gig at My­onexus, too, ac­cord­ing to Sarep­ta’s state­ment.

“Mak­ing an im­pact on the lives of pa­tients af­fect­ed by mus­cu­lar dy­s­tro­phies has been cen­tral to my pro­fes­sion­al work,” said Rodi­no-Kla­pac. “Sarep­ta’s RNA plat­forms and mul­ti­ple gene ther­a­py pro­grams pro­vide sig­nif­i­cant op­por­tu­ni­ty to make a pro­found dif­fer­ence for pa­tients with neu­ro­mus­cu­lar dis­eases. I’m ex­cit­ed to join the Sarep­ta team lead­ing its gene ther­a­py de­vel­op­ment ef­forts, and share the or­ga­ni­za­tion’s ur­gency to ad­vance its ro­bust pipeline of po­ten­tial ther­a­pies.”

Sarep­ta’s CEO Doug In­gram had this to say:

Her ap­point­ment to lead our gene ther­a­py di­vi­sion per­fect­ly ex­em­pli­fies our strat­e­gy of quick­ly be­com­ing among the most mean­ing­ful glob­al ge­net­ic med­i­cine com­pa­nies by re­tain­ing and nur­tur­ing the field’s best and bright­est gene ther­a­py and neu­ro­mus­cu­lar sci­en­tists. It would be chal­leng­ing to find a sci­en­tist that has matched Dr. Rodi­no-Kla­pac’s record of ad­vanc­ing our un­der­stand­ing of gene ther­a­py and its ap­pli­ca­tion to neu­ro­mus­cu­lar con­di­tions while ac­cel­er­at­ing bench-side re­search in­to hu­man clin­i­cal tri­als.

Im­age: Louise Rodi­no-Kla­pac. NA­TION­WIDE CHIL­DREN’S HOS­PI­TAL

BiTE® Plat­form and the Evo­lu­tion To­ward Off-The-Shelf Im­muno-On­col­o­gy Ap­proach­es

Despite rapid advances in the field of immuno-oncology that have transformed the cancer treatment landscape, many cancer patients are still left behind.1,2 Not every person has access to innovative therapies designed specifically to treat his or her disease. Many currently available immuno-oncology-based approaches and chemotherapies have brought long-term benefits to some patients — but many patients still need other therapeutic options.3

Mark Genovese (Stanford via Twitter)

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Fangliang Zhang (Imaginechina via AP Images)

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Bris­tol My­ers Squib­b's just-launched MS drug Zeposia makes the cut in key ul­cer­a­tive col­i­tis tri­al

In March, Zeposia became the third oral S1P modulator to secure US approval for multiple sclerosis. Now, the drug has succeeded in a key ulcerative colitis study.

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