Shreds of Tregs: French biotech wins Medicxi backing to kill the rogue immunosuppressive agent to fight cancer
Existing CD25 drugs tend to thwart IL-2 signaling, which is imperative to shaping the body’s immune response. But a French drug developer thinks it has found a way to snuff out regulatory T cells (known to contribute to the early establishment and progression of tumors) by targeting CD25 without disturbing IL-2, and now has €18.5 million in its coffers to prove it.
The Parisian company, Alderaan Biotechnology, is still very early in its journey. The Series A round of funding from Advent France Biotechnology (AFB) and Medicxi will be used to complete the preclinical development of its regulatory T cell (Tregs) depleting CD25-specific antibody and take it into the clinic by 2022.
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