Watch out Alnylam/Ionis: Pfizer’s positive PhIII tafamidis data makes drug a new rival
Pfizer $PFE reported out some good news from a late-stage trial testing its drug tafamidis against a rare condition that leads to heart failure. The positive results of the Phase III study have both Alnylam $ALNY and Ionis $IONS investors squeamish, as it could be competition for patisiran and inotersen.
The Pfizer trial, called ATTR-ACT, tested its drug tafamidis in patients with transthyretin cardiomyopathy, an inherited condition in which proteins don’t fold into their normal shapes correctly. The misfolding makes them build up and cause damage to the nerves, heart, and other organs. In the trial, the drug met its primary endpoint, Pfizer said, and demonstrated a statistically significant reduction in the combination of all-cause mortality and frequency of cardiovascular-related hospitalizations compared to placebo at 30 months.
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