The new top 10 most ex­pen­sive drugs on the plan­et

Bio­Marin’s de­ci­sion last night to set the whole­sale ac­qui­si­tion cost of its new ul­tra rare dis­ease drug Brineu­ra for CLN2 at $702,000 — with a sig­nif­i­cant­ly low­er net amount — cre­ates a new en­try in the list of the 10 most ex­pen­sive ther­a­pies in the world. With uniQure’s gene ther­a­py Gly­bera un­used and head­ing for the shelves, we al­so de­cid­ed to drop that, leav­ing Hori­zon in the top slot with its WAC price for Hori­zon’s Rav­ic­ti, at *$793,632, ac­cord­ing to the orig­i­nal line­up from Rein­sur­ance Group of Amer­i­ca. Brineu­ra is the new num­ber 2. We’ll al­so note that you could ar­gue for a place on this list for Bio­gen’s Spin­raza, which starts with a $750,000 price for its first year, but then drops by half, falling be­low the new top 10.

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