Thermo Fisher's new manufacturing site in Chelmsford, MA

Ther­mo Fish­er con­tin­ues its ex­pan­sion dri­ve with open­ing of $160M Mass­a­chu­setts fa­cil­i­ty

Ther­mo Fish­er is look­ing much clos­er to home for its lat­est open­ing.

On Tues­day, the man­u­fac­tur­er opened a new $160 mil­lion, 85,000 square-foot fa­cil­i­ty in Chelms­ford, MA, 30 miles north of its head­quar­ters in Waltham. Ac­cord­ing to a Ther­mo Fish­er spokesper­son, the com­pa­ny broke ground on the site in 2020.

The Chelms­ford site al­so is part of a wider $650 mil­lion in­vest­ment that Ther­mo Fish­er has made in new sites across the US, UK, Sin­ga­pore and Chi­na.

The site will pro­duce resins that are used in med­i­cines and bi­o­log­ics as well as cell and gene ther­a­pies, ac­cord­ing to a spokesper­son. The spokesper­son al­so con­firmed that pro­duc­tion has al­ready be­gun.

The fa­cil­i­ty al­so will be able to hold around 250 em­ploy­ees when ful­ly staffed and cur­rent­ly em­ploys 140.

“The Chelms­ford site will help us pro­vide our cus­tomers with the crit­i­cal resin ma­te­ri­als they need as they scale up pro­duc­tion and bring new in­no­va­tions to mar­ket. This ul­ti­mate­ly helps en­sure more pa­tients get the treat­ments they need faster,” said Jean Luo, VP and gen­er­al man­ag­er for pu­rifi­ca­tion and phar­ma an­a­lyt­ics at Ther­mo Fish­er, in a state­ment.

Ther­mo Fish­er is in­vest­ing heav­i­ly in the Bay State, as it opened a $180 mil­lion, 300,000-square- foot vi­ral vec­tor man­u­fac­tur­ing site in Plain­view, about 48 miles from Boston, on­ly a few weeks ago.

As part of this $650 mil­lion in­vest­ment, the com­pa­ny has been steadi­ly open­ing sites across the na­tion through­out the year too.

In April, the com­pa­ny opened a $44 mil­lion site in Utah that man­u­fac­tures bio­process con­tain­er sys­tems.

Last month, the com­pa­ny re­al­ly picked up the pace as it opened new fa­cil­i­ties, in­clud­ing a $76 mil­lion cell cul­ture man­u­fac­tur­ing site opened out­side of Buf­fa­lo, NY, and a $105 mil­lion bi­o­log­ics site in Lebanon, TN, just out­side of Nashville.

Roger Perl­mut­ter lines up deals, fresh fund­ing at Eikon; Sec­ond RSV vac­cine ap­proved; Sev­er­al biotechs flash­ing red; and more

Welcome back to Endpoints Weekly, your review of the week’s top biopharma headlines. Want this in your inbox every Saturday morning? Current Endpoints readers can visit their reader profile to add Endpoints Weekly. New to Endpoints? Sign up here.

As you come back to our website this weekend for ASCO news, don’t forget to check out our updated event lineup at BIO, which will cover everything from the current state of VC investing in biotech to top pharma R&D chiefs discussing how to make pipeline decisions.

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Image courtesy of The Janssen Pharmaceutical Companies of Johnson & Johnson.

Pro­tect­ing the glob­al phar­ma­ceu­ti­cal in­no­va­tion ecosys­tem – what’s at stake?

We are living in a new era of healthcare that is rapidly advancing progress impacting patient outcomes and experiences. We’ve seen a remarkable pace of transformational innovation, applied research, and advanced clinical development over the last decade.

Despite this tremendous progress, there is much more work to be done, and patients are counting on us – now more than ever – to continue that momentum. At the heart of our industry is a focus on developing and delivering medicines for some of the world’s most challenging diseases, including those that have few or no effective treatments today.

Roger Perlmutter, Eikon Therapeutics CEO

Roger Perl­mut­ter builds Eikon's pipeline with deal-mak­ing flur­ry, rais­ing $106M more

Eikon Therapeutics announced three business development deals on Thursday, effectively dropping in a pipeline of cancer drugs alongside more than $100 million in fresh funding.

The Hayward, CA-based company has become one of biotech’s richest startups since its 2019 founding, having raised nearly $775 million. It’s developing a massive, automated research approach built around Nobel Prize-winning microscope science to peer inside cells and watch proteins in action. After its Series B last year, PitchBook reported a $3.02 billion valuation. And while CEO Roger Perlmutter declined to comment on that figure, he said its first tranche of nearly $106 million in Series C funding is a “meaningful step-up to our Series B valuation.”

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Catal­ent makes ad­di­tion­al lay­offs at In­di­ana fa­cil­i­ty

Contract manufacturer Catalent is making more staff cuts at one of its locations in the US amid dramatic corrective actions it’s been taking over the past few months.

In an email to Endpoints News, a Catalent spokesperson confirmed the company is making “a number of personnel changes” at a manufacturing facility in Bloomington, IN. While a specific number was not given to Endpoints, several local media outlets, including Indiana Public Media and the Bloomington Herald-Times, have put the number of layoffs at 150. No postings have been made to the Indiana Department of Workforce Development’s WARN notice.

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Roche plans to di­vest from lega­cy Genen­tech man­u­fac­tur­ing fa­cil­i­ty in Cal­i­for­nia

Roche is planning to make some changes to its subsidiary’s manufacturing network in California.

The Swiss pharma announced Wednesday that it plans to divest from Genentech’s manufacturing facility in Vacaville, CA, around 58 miles northeast of San Francisco. According to a statement from Roche, the move is part of a “broader strategy” to bring its manufacturing capabilities in line with its future pipeline. Roche is starting the process of finding a buyer for the site but has not named any candidates yet.

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Peter van de Sande, Synaffix CEO

Lon­za shells out $107M cash to snap up Synaf­fix and its ADC plat­form

After lining up a string of partnerships over the years, Dutch antibody-drug conjugate specialist Synaffix has found a new home: Lonza, the contract development and manufacturing giant.

Lonza is paying about $107 million (€100 million) in cash to acquire Synaffix, with up to $64 million (€60 million) in “additional performance-based consideration” on the table. Synaffix’s ADC tech platform will now become part of Lonza’s offering for biopharma clients, lending its bioconjugate technologies to not just ADCs but also targeted gene therapy, immune cell engagers and other applications.

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Grail’s blood test charts path for di­ag­nos­ing pa­tients sus­pect­ed of hav­ing can­cer in large study: #AS­CO23

Grail’s vision is simple but bold. The blood testing company has long held that people are often diagnosed with cancer too late. If seemingly healthy people were screened for early signs of the disease before symptoms appear, they may be able to get more effective treatments that nip cancer in the bud.

That premise is the basis of Grail’s commercial blood test, Galleri, which searches for the genetic fingerprints of cancer in the blood. The test, launched in 2021, reaped $55 million in sales last year, but now the company is setting its sights on a new market: patients suspected of having cancer due to symptoms such as abdominal pain, rectal bleeding or unexplained weight loss. Rather than administering expensive scans or conducting invasive biopsies right away, Grail hopes doctors will consider a simple blood test.

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Bala Venkataraman, Avego founder and managing partner (L), and Bruno Paquin, AtomVie CEO

Cana­di­an CD­MO se­cures more fund­ing to get its man­u­fac­tur­ing site up and run­ning

AtomVie Global Radiopharma Inc, a Canadian radiopharmaceutical contract manufacturer, has received additional funds to get its manufacturing facility up and running.

The manufacturer announced that it has raised an additional 90 million Canadian dollars ($66.9 million) in a “Tranche 2 Series A round,” led by the healthcare investment firm Avego Management. The company previously announced a $40 million Series A round last year, which contributed to the construction of a new 64,000-square-foot facility.

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GSK pro­motes rou­tine im­mu­niza­tions for adults amid post-pan­dem­ic vac­cine back­slide

GSK launched a new initiative on Thursday and committed up to $1 million in grant funding to improve adult routine vaccination rates.

While the pandemic spotlight was trained on the race for novel Covid-19 vaccines, other routine vaccination rates plummeted, raising concerns that missed doses may put children and even some adults at risk of preventable diseases such as measles or shingles. The World Health Organization last year reported the largest drop in childhood vaccinations in roughly three decades.

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