Theseus goes back to preclinical mode after axing lead targeted therapy over tolerability concerns, shares plummet
Theseus Pharmaceuticals has run into dose-limiting toxicities that’s forcing the company to abandon its KIT inhibitor, two months after presenting initial data on the program at ASCO.
Researchers are winding down the ongoing Phase I/II study and ending the development of THE-630 in patients with gastrointestinal stromal tumors (GIST) altogether after investigators flagged two cases of hand-foot skin reaction out of six patients who got a 27 mg dose.
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