Versant-backed precision oncology startup Repare Therapeutics scores $82M+ in latest round
More than two years after emerging out of stealth mode with $68 million and Versant as a founding investor, precision oncology drug developer Repare Therapeutics has scored another $82.5 million to take its lead product — carved out of the biotech’s synthetic lethality platform — into the clinic.
Synthetic lethality is a concept that relies on the idea that while tumors can tolerate individual defects in DNA, combinations of defects create distinct vulnerabilities in cancer cells which, when isolated, present opportunities for precision therapeutics. For instance, PARP inhibitors — such as Clovis’ Rubraca, AstraZeneca’s $AZN Lynparza and GSK’s $GSK Zejula — were developed to treat cancers with mutations in BRCA1 or BRCA2 genes.
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