With an assist from AstraZeneca, the salvage crew at Sierra bets another $216M they can resurrect an old Gilead JAK drug
Almost a decade ago, Gilead shelled out $510 million in cash for YM BioSciences and its only drug, a JAK inhibitor for a rare type of bone marrow cancer called myelofibrosis. But when the candidate didn’t show any benefit over its rival, Incyte’s Jakafi, the molecule ended up in the hands of Sierra Oncology.
Now, confident it’s got a diamond in the rough, Sierra $SRRA is putting that drug, momelotinib, through another Phase III trial in myelofibrosis. And on Thursday, the biotech unveiled a $216 million deal for the rights to AstraZeneca’s BRD4 BET inhibitor AZD5153, which it plans on putting through a Phase II trial in combination with momelotinib.
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