De­spite a suite of in­no­va­tions in on­co­log­ic ther­a­py, metasta­t­ic can­cer re­mains one of the lead­ing killers of US pa­tients, and the un­der­ly­ing dri­vers of its growth are still lit­tle known. A West Harlem biotech is look­ing at one po­ten­tial path to solv­ing metas­ta­sis, and now it’s work­ing with a high-pro­file part­ner to speed its ef­forts.

Volas­tra has closed an ex­pand­ed $44 mil­lion Se­ries A and iced a deal with Mi­crosoft to de­vel­op new dig­i­tal tools to iden­ti­fy bio­mark­ers for can­cer metas­ta­sis based on the com­pa­ny’s work study­ing chro­mo­so­mal in­sta­bil­i­ty, the biotech said in a pair of re­leas­es Tues­day.

Lewis Cant­ley

Found­ed on sci­ence from co-founders Lewis Cant­ley, Olivi­er El­e­men­to and Samuel Bakhoum, Volas­tra is look­ing to dis­cov­er and de­vel­op nov­el drugs tar­get­ing chro­mo­so­mal in­sta­bil­i­ty, a key dri­ver in the metasta­t­ic can­cer. The biotech us­es ar­ti­fi­cial in­tel­li­gence to iden­ti­fy bio­mark­ers for chro­mo­so­mal in­sta­bil­i­ty “at scale,” CEO Charles Hugh-Jones told End­points News, and is work­ing to de­vel­op nov­el mol­e­cules across three broad po­ten­tial modal­i­ties: im­mune ac­ti­va­tion, syn­thet­ic lethal­i­ty and CIN-path­way mod­u­la­tion.

The key there is “at scale,” and that’s the idea that sparked the part­ner­ship with Mi­crosoft. The tech gi­ant will pit its “com­put­er vi­sion” plat­form, which crunch­es da­ta sets for vi­su­al fea­tures, against Volas­tra’s grow­ing chro­mo­so­mal in­sta­bil­i­ty da­ta sets and hope­ful­ly be­gin churn­ing out bio­mark­ers soon­er than you might think.

Charles Hugh-Jones

“They’re re­al­ly in­ter­est­ed in how they can ap­ply their ma­chine vi­sion al­go­rithms and we’re bring­ing to the ta­ble the chro­mo­so­mal in­sta­bil­i­ty ex­per­tise,” Hugh-Jones said. “Com­bin­ing those two, we will have by the third quar­ter of this year a ma­chine vi­sion plat­form where we bulk iden­ti­fy chro­mo­so­mal in­sta­bil­i­ty.”

With that high-pro­file deal in place, Volas­tra will al­so take a fresh round of in­vestor cash to scale its own in­ter­nal dis­cov­ery plat­form and po­ten­tial­ly be ready to start un­veil­ing lead com­pounds in the near fu­ture. The biotech cur­rent­ly has two leads un­der wraps, Hugh-Jones said, and is look­ing to get in­to first hu­man stud­ies by ear­ly 2023.

Chro­mo­so­mal in­sta­bil­i­ty is a ripe field for study giv­en its role in dri­ving metasta­t­ic can­cer, which is di­ag­nosed in about 350,000 US pa­tients each year. On­ly about a third of those re­spond to tar­get­ed or im­munother­a­pies, Volas­tra said, leav­ing the door open for a wide range of al­ter­na­tive modal­i­ties.

The $44 mil­lion round ex­pands Volas­tra’s seed fund­ing and was head­lined by new in­vestors Vi­da Ven­tures and Catalio Cap­i­tal Man­age­ment, which joined a syn­di­cate that in­cludes Po­laris Part­ners, Droia Ven­tures, ARCH Ven­ture Part­ners and Quark Ven­ture.

Hugh-Jones joined the team in Sep­tem­ber, which bloomed pri­mar­i­ly from the work of Cor­nell’s Cant­ley, who dis­cov­ered the PI3K path­way in on­col­o­gy.

In biopharma, driving a drug to market is the ultimate goal — but none of that happens without a strong research and development program. At the most successful companies, those R&D efforts are spearheaded by true innovators in the field who are always looking for that next novel mechanism of action or breakthrough safety profile.

Now, Endpoints News is asking you to tell us who those guiding lights are.

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Hutchmed — recently renamed from Chi-Med, or Hutchison China MediTech — will look to raise $603 million as part of a Hong Kong IPO that serves as a homecoming of sorts for the Chinese-based oncology player, which has listed on Nasdaq since 2016.