In light of In­cyte's epaca­do­stat de­ba­cle, NewLink scraps PhI­II plans for its own IDO drug

Af­ter see­ing its shares get dragged down by In­cyte’s late-stage de­ba­cle, NewLink Ge­net­ics is scrap­ping a PhI­II tri­al for its own IDO drug, rais­ing fur­ther ques­tions about the path­way.

It will not ini­ti­ate the ran­dom­iza­tion por­tion of In­di­go301, the Ames, IA-based com­pa­ny $NLNK said, a melanoma study that would have eval­u­at­ed in­dox­i­mod in com­bi­na­tion with check­point in­hibitors Keytru­da or Op­di­vo in 600 pa­tients. In a press re­lease, NewLink ex­plained the de­ci­sion was made “in the con­text of the fail­ure of a com­peti­tor’s tri­al of its en­zy­mat­ic IDO in­hibitor in a sim­i­lar clin­i­cal set­ting.”

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