A Pfiz­er part­ner wel­comes ex-ADC Ther­a­peu­tics CMO Jay Fein­gold to the team; Amid tough sled­ding, Im­muno­vant choos­es Eli Lil­ly alum as CFO

Jay Fein­gold

→ Last week we told you about the CMO re­volv­ing door at ADC Ther­a­peu­tics, as Joseph Ca­mar­do re­placed the de­part­ing Jay Fein­gold. The next op­por­tu­ni­ty for Fein­gold in the CMO slot has opened up at an­ti­body-drug con­ju­gate and mAb de­vel­op­er Pyx­is On­col­o­gy, which has added sev­er­al new ex­ecs and sci­en­tif­ic ad­vi­so­ry board mem­bers in re­cent months, in­clud­ing ex-Im­muno­vant CFO Pamela Yanchik Con­nealy. Be­fore his tenure at ADC, Fein­gold was Dai­ichi Sankyo’s VP of US med­ical af­fairs and chair­man of the Glob­al Med­ical Af­fairs Over­sight Com­mit­tee. With­in weeks in March, Pyx­is struck a li­cens­ing deal with Pfiz­er for two of its AD­Cs and raked in $152 mil­lion from a Se­ries B round.

Re­nee Bar­nett

→ Mean­while, Im­muno­vant has found Con­nealy’s re­place­ment, se­lect­ing Re­nee Bar­nett as fi­nance chief a month af­ter Roivant de­cid­ed to pump $200 mil­lion in­to a mem­ber of Vivek Ra­maswamy’s Vant fam­i­ly that has wres­tled with tri­al sus­pen­sions and freefalling stocks. Un­til now the chief in­te­gra­tion of­fi­cer at tele­men­tal health provider Able­To, Bar­nett has spent a large por­tion of her ca­reer at Eli Lil­ly, ris­ing to CFO of Aus­tria & Switzer­land and lat­er di­rec­tor of fi­nan­cial plan­ning & analy­sis. LDL lev­els (the bad cho­les­terol) shot up con­sid­er­ably in pa­tients on the high and low dos­es of Im­muno­vant’s an­ti­body IMVT-1401 for thy­roid eye dis­ease in Feb­ru­ary, and new da­ta in June did lit­tle to quell con­cerns even as Im­muno­vant al­so forges ahead with IMVT-1401 in myas­the­nia gravis and warm au­toim­mune he­molyt­ic ane­mia (WAI­HA).

An­drew Pec­o­ra

Robert Hariri has a new pres­i­dent work­ing along­side him at New Jer­sey-based Celu­lar­i­ty, an­oth­er biotech that chose the SPAC route to gal­lop in­to Nas­daq — do­ing so here with GX Ac­qui­si­tion Corp. A hema­tol­o­gist and on­col­o­gist, An­drew Pec­o­ra was pres­i­dent of the Physi­cian En­ter­prise and chief in­no­va­tion of­fi­cer at Hack­en­sack Merid­i­an Health, and he co-found­ed, chaired and helmed Prog­en­i­tor Cell Ther­a­py. When the merg­er closed in Ju­ly, Hariri told our Am­ber Tong that Celu­lar­i­ty had waved the white flag on its Covid-19 ef­forts with its NK cell ther­a­py ap­proach: “The change in man­age­ment of pa­tients at the hos­pi­tal set­ting made it very very dif­fi­cult to find pa­tients who met the in­clu­sion cri­te­ria,” he said.

Jesse Hall

→ One month sep­a­rates big hires at San Fran­cis­co’s Al­tru­Bio, with Jesse Hall join­ing Judy Chou’s squad as CMO fol­low­ing the in­tro­duc­tion of CFO Jeroen Gras­man in ear­ly Au­gust. Since 2018, Hall was CMO for Sub­lim­i­ty Ther­a­peu­tics be­fore tak­ing on the same role at Al­tru­Bio, which brought in a $63 mil­lion Se­ries A haul in the spring and has a Phase Ib study un­der­way for graft-ver­sus-host dis­ease with its lead drug nei­hulizum­ab. From 2009-13, Hall was a med­ical di­rec­tor at Am­gen be­fore be­com­ing an ex­ec­u­tive med­ical di­rec­tor at Ardea Bio­sciences.

In­grid Simms

→ San Diego pre­ci­sion on­col­o­gy biotech Lengo Ther­a­peu­tics — where Dave John­son and Enoch Kar­iu­ki have re­unit­ed as chair­man and CEO re­spec­tive­ly af­ter their Velos­Bio days — has three new ex­ecs on the ros­ter, in­clud­ing an­oth­er fa­mil­iar face. In­grid Simms (SVP and prin­ci­pal ac­count­ing of­fi­cer) held the same ti­tle at Velos­Bio and from 2013-20 was the VP of fi­nance for Alder Bio­Phar­ma­ceu­ti­cals. Paul Pear­son (chief of de­vel­op­ment) was ex­ec­u­tive di­rec­tor of pre­clin­i­cal drug me­tab­o­lism dur­ing his years at Mer­ck Re­search Lab­o­ra­to­ries, and lat­er be­came Am­gen’s glob­al head of phar­ma­co­ki­net­ics and drug me­tab­o­lism. And the 11 years at Pfiz­er’s La Jol­la Lab­o­ra­to­ries for Er­ic Gruff (SVP of CMC) cul­mi­nat­ed in his role as re­search team leader in de­vel­op­ment of di­a­betes and frailty (mus­cle wast­ing) ther­a­pies.

→ By rais­ing a sub­stan­tial chunk of change for its Se­ries B in Au­gust, Jef­frey Blue­stone’s Sono­ma Bio­ther­a­peu­tics has 265 mil­lion rea­sons to grab every­one’s at­ten­tion, and this week Sono­ma has pulled in Doug Shee­hy as chief le­gal of­fi­cer and sec­re­tary. The ex-gen­er­al coun­sel and sec­re­tary at Aim­mune, Shee­hy al­so de­vot­ed nine years to Codex­is, where he was EVP, chief ad­min­is­tra­tive of­fi­cer, gen­er­al coun­sel and sec­re­tary.

Gu­darz Davar

→ CNS dis­ease-fo­cused Au­to­bahn Ther­a­peu­tics out of San Diego, lift­ing the lid in June 2020 with a $76 mil­lion round head­lined by ARCH and Cowen, has tapped Gu­darz Davar as CMO and pro­mot­ed Chan Beals to SVP, chief of trans­la­tion­al med­i­cine. Davar — who can sing his own vers­es of John­ny Cash’s “I’ve Been Every­where” with stints at Am­gen, Al­ler­gan and Bio­gen un­der his belt — just led R&D for a year at Aca­dia Phar­ma­ceu­ti­cals af­ter he was in charge of glob­al neu­rol­o­gy clin­i­cal de­vel­op­ment at Eli Lil­ly. Beals sped in­to Au­to­bahn in Jan­u­ary 2020 as SVP of trans­la­tion­al med­i­cine, and ear­li­er he was CMO at Abide Ther­a­peu­tics, which Lund­beck bought to boost a scuf­fling pipeline in the spring of 2019.

Sun­jeet Sawh­ney

No­vo Seeds led a mod­est fi­nanc­ing round in Oc­to­ber 2020 for Finnish can­cer start­up Rapp­ta Ther­a­peu­tics, fo­cused on pro­tein phos­phatase 2 (PP2A) in­hibitors. Found­ing CEO Mikko Man­nerkos­ki is slid­ing in­to the CFO role at Rapp­ta as Sun­jeet Sawh­ney steps in­to the spot­light in his place, ef­fec­tive im­me­di­ate­ly. Sawh­ney hails from Ipsen, where the new chief ex­ec­u­tive was glob­al head of the on­col­o­gy fran­chise, and his Big Phar­ma ex­pe­ri­ence start­ed ear­ly at Roche and Sanofi be­fore ris­ing to on­col­o­gy head of mar­ket­ing & com­mer­cial ex­cel­lence, emerg­ing growth mar­kets to con­clude his nine years at No­var­tis On­col­o­gy.

→ Start­ing Mon­day, Erik Skullerud will be CEO at Oslo, Nor­way-based Nordic Nanovec­tor, which takes aim at hema­to­log­i­cal can­cers with its ra­dioim­muno­con­ju­gate (RIC) Be­talutin. Skullerud suc­ceeds Ma­lene Brond­berg af­ter she had held the top spot on an in­ter­im ba­sis since Ju­ly. From 2000-16, Skullerud scaled the sales and mar­ket­ing peaks at Am­gen, leav­ing as the Big Phar­ma’s mar­ket­ing di­rec­tor, Eu­rope, on­col­o­gy/hema­tol­ogy.

Lars Boes­gaard

→ Stay­ing in Eu­rope, Dutch biotech AM-Phar­ma has brought on Lars Boes­gaard to be its CFO. The first AM-Phar­ma ex­ec­u­tive to be based in the US, the No­vo Nordisk and Alex­ion vet joins the com­pa­ny from Co­lum­bia Care just a week af­ter Ky­owa Kirin paid the biotech more than $23 mil­lion up­front for de­vel­op­ment and com­mer­cial­iza­tion rights in Japan on kid­ney drug ilo­fo­tase al­fa.

Tim­o­thy Ki­ef­fer

→ Proof-of-con­cept da­ta from a sin­gle pa­tient were re­leased in June from Vi­a­Cyte’s stem cell treat­ment for type 1 di­a­betes, and CEO Michael Yang has found a new CSO with the req­ui­site stem cell back­ground in this in­di­ca­tion. Tim­o­thy Ki­ef­fer was in charge of the Lab­o­ra­to­ry of Mol­e­c­u­lar and Cel­lu­lar Med­i­cine at the Uni­ver­si­ty of British Co­lum­bia, where he was al­so part of the Di­a­betes Re­search Group at the school’s Life Sci­ences In­sti­tute. The en­Gene co-founder re­places Kevin D’Amour, now the chief sci­en­tist at Brook­lyn Im­munoTher­a­peu­tics.

Ian Clark

Kyver­na Ther­a­peu­tics has re­cruit­ed two new faces with the ap­point­ments of for­mer Genen­tech CEO Ian Clark as chair of its board of di­rec­tors and Karen Walk­er as chief tech­nol­o­gy of­fi­cer. Pri­or to his sev­en-year tenure at the helm of Genen­tech, Clark was serv­ing as the com­pa­ny’s EVP of com­mer­cial op­er­a­tions and SVP and gen­er­al man­ag­er of bio-on­col­o­gy. Ear­li­er in his ca­reer, Clark served in a va­ri­ety of roles at No­var­tis, Sanofi, Ivax and Sear­le. This is far from Clark’s first board seat; he cur­rent­ly sits on the boards of Take­da, Agios Phar­ma­ceu­ti­cals, Guardant Health, Ole­ma Phar­ma­ceu­ti­cals, Corvus Phar­ma­ceu­ti­cals and Avro­bio.

Mean­while, Walk­er comes to Kyver­na af­ter stints at Roche/Genen­tech, Seagen, No­var­tis, Am­gen, Bay­er and Bris­tol My­ers Squibb. Walk­er most re­cent­ly served as se­nior ad­vi­sor, cell and gene ther­a­py man­u­fac­tur­ing at Roche/Genen­tech.

Found­ed by Bob Langer and head­ing in­to Phase III with its lead drug for chron­ic rhi­nos­i­nusi­tis, Lyra Ther­a­peu­tics has locked in Ja­son Cav­a­lier as CFO. Af­ter stops at Bear Stearns, Bar­clays and RBC Cap­i­tal Mar­kets, Cav­a­lier was Can­tor Fitzger­ald’s man­ag­ing di­rec­tor, head of life sci­ences merg­ers & ac­qui­si­tions.

Han Lee

Han Lee will de­part from his CFO po­si­tion at Ar­cel­lx to per­form the same role at Neo­gene Ther­a­peu­tics. Pri­or to Ar­cel­lx, Lee served as se­nior di­rec­tor in the cor­po­rate de­vel­op­ment and ven­tures group at As­traZeneca. Over the sum­mer, the South­ern Cal­i­for­nia TCR biotech al­so added Brent Pfeif­f­en­berg­er as COO.

David Liebowitz is step­ping over to Hous­ton-based DNA­trix as CMO. Liebowitz most re­cent­ly served as VP of clin­i­cal on­col­o­gy at Xen­cor. Pri­or to that stint, Liebowitz was the CMO for Vaxart and CSO and CMO of Vi­val­di Bio­sciences. Ear­li­er in his ca­reer, Liebowitz was with Galileo Phar­ma­ceu­ti­cals, Am­gen and Im­munex.

Jaa Rober­son

→ The sun shone bright­ly over South San Fran­cis­co pe­di­atric can­cer play­er Day One Bio­phar­ma­ceu­ti­cals when it start­ed trad­ing on Nas­daq with the tick­er $DAWN af­ter an up­sized IPO hit $160 mil­lion in May. CEO Je­re­my Ben­der con­tin­ues to piece to­geth­er the C-suite with Jaa Rober­son climb­ing on board as chief peo­ple of­fi­cer, piv­ot­ing from her role as a hu­man re­sources ex­ec at Bel­licum. Af­ter six years at Genen­tech as an HR busi­ness part­ner, Rober­son spent a year lead­ing HR at Achao­gen.

John Limon­gel­li

→ Thomas Jef­fer­son Uni­ver­si­ty spin­out Im­vax, led by ex-Spark COO John Furey, has locked in John Limon­gel­li as chief le­gal of­fi­cer. Limon­gel­li was gen­er­al coun­sel at Neos Ther­a­peu­tics and then at Tra­ve­na, where he tacked on the chief ad­min­is­tra­tive of­fi­cer ti­tle. Im­vax re­vealed pos­i­tive Phase Ib da­ta on its glioblas­toma mul­ti­forme drug IGV-001 in Jan­u­ary and has brought COO Sean Hem­ing­way and CFO Josh Munt­ner in­to the fold this year.

→ Pitts­burgh’s Krys­tal Biotech has added Lau­rent Goux as their gen­er­al man­ag­er for Eu­rope. Goux comes from Swiss der­ma­to­log­i­cal phar­ma Gal­der­ma, where he was in charge of glob­al strate­gic mar­ket­ing and mar­ket ac­cess. Krys­tal Biotech is in the mid­dle of a Phase III tri­al for epi­der­mol­y­sis bul­losa.

NeuBase Ther­a­peu­tics resur­faces in Peer Re­view yet again, as the Pitts­burgh ge­net­ic med­i­cine biotech waves in An­tho­ny Rosso­man­do as chief tech­nol­o­gy of­fi­cer. A staff sci­en­tist at Bay­er in the 1990s, Rosso­man­do has roamed the land­scape ex­ten­sive­ly, from his nine years at Bio­gen to his three years at Al­ny­lam as se­nior di­rec­tor of siR­NA bio­pro­cess­ing. The Anokion and Alex­ion vet heads to NeuBase af­ter a brief stay as chief process de­vel­op­ment of­fi­cer at Pine­tree Ther­a­peu­tics. With­in a year’s time, NeuBase has al­so bol­stered its C-suite with a new COO, CSO, CMO and chief busi­ness and strat­e­gy of­fi­cer.

Neal Mu­ni

→ Just a week af­ter tap­ping Jeff Hack­man as pres­i­dent and CEO, Re­Form Bi­o­log­ics is bring­ing in Neal Mu­ni as EVP and COO. Pri­or to join­ing Re­Form, Mu­ni most re­cent­ly served as the CEO of Azu­ri­ty, which is­sued a na­tion­al re­call of one lot of Fir­vanq last week.

→ Vi­va LaFrance: Part­ner­ing with Ra­dioMedix on the pro­duc­tion of its ra­dio­phar­ma­ceu­ti­cals, Plus Ther­a­peu­tics out of Austin, TX has ap­point­ed Nor­man LaFrance as CMO ef­fec­tive “on or around” Dec. 8. Be­fore join­ing the ra­dio­ther­a­peu­tic de­vel­op­er, LaFrance was SVP and CMO of Ju­bi­lant Phar­ma, and in the mid 2000s the for­mer mem­ber of the Johns Hop­kins med­ical fac­ul­ty was Bausch + Lomb’s VP, glob­al phar­ma­ceu­ti­cal de­vel­op­ment.

Gus­ta­vo Stolovitzky

Se­ma4, the J&J and Sanofi-part­nered pa­tient da­ta, test­ing and ge­nomics plat­form that merged with Eli Cas­din’s $450 mil­lion SPAC, has pulled in Gus­ta­vo Stolovitzky as CSO. Stolovitzky has spent the last two decades at IBM Re­search, where he was ap­point­ed IBM fel­low. Pri­or to his ap­point­ment as fel­low, Stolovitzky was the di­rec­tor of the trans­la­tion­al sys­tems bi­ol­o­gy and nanobiotech­nol­o­gy pro­gram.

Re­solve Bio­sciences has named Erik Wiberg as CFO. Wiberg comes aboard from RE­VA Med­ical, where he al­so served as CFO. Pri­or to his stint at RE­VA, Wiberg served at Gy­ros Pro­tein Tech­nolo­gies, Ther­mo Fish­er Sci­en­tif­ic, Al­liedSig­nal and the Cham­ber­lain Group.

Wendy Dwyer

San­iona has brought on Wendy Dwyer as CBO. Dwyer joins the com­pa­ny from Sur­face On­col­o­gy, where she served in the same role as CBO. Dwyer brings with her ex­pe­ri­ence from her time at Por­tal In­stru­ments, Ipsen Bio­science, As­traZeneca, Anti­gen­ics (now Agenus), En­do Phar­ma­ceu­ti­cals and In­de­vus Phar­ma­ceu­ti­cals.

In ad­di­tion, the San­iona has giv­en a seat to Robert Hoff­man on its board of di­rec­tors. This isn’t Hoff­man’s first board ap­point­ment, he cur­rent­ly sits on the boards of ASLAN Phar­ma­ceu­ti­cals, Kin­tara Ther­a­peu­tics and An­tibe Ther­a­peu­tics. Most re­cent­ly, Hoff­man served as CFO of Heron Phar­ma­ceu­ti­cals. Hoff­man jump­start­ed his ca­reer at Are­na Phar­ma­ceu­ti­cals.

Xen­ter has wel­comed Mark Tur­co aboard as pres­i­dent of its Xen­ter Med­ical Tech­nolo­gies busi­ness unit. Tur­co hails from Sir­tex Med­ical, where he served as EVP of re­search & de­vel­op­ment and glob­al CMO. In ad­di­tion, Tur­co pre­vi­ous­ly served as CMO of Co­vi­di­en and lat­er VP and CMO of Medtron­ic’s aor­tic, pe­riph­er­al and vas­cu­lar di­vi­sions.

Marni Kot­tle

Nor­bert Bischof­berg­er at Kro­nos Bio has looked to his old stomp­ing grounds at Gilead to wel­come Marni Kot­tle as SVP of cor­po­rate com­mu­ni­ca­tions and in­vestor re­la­tions. Kot­tle joined Gilead in 2013, over­lap­ping with Bischof­berg­er’s 28-year run with the Cal­i­for­nia phar­ma, and was VP of cor­po­rate com­mu­ni­ca­tions af­ter a ca­reer in me­dia where she was a re­porter for the San Fran­cis­co Chron­i­cle, Bloomberg and the Seat­tle Post-In­tel­li­gencer. Kro­nos got in on the 2020 IPO craze last fall, top­ping $250 mil­lion in an up­sized of­fer­ing.

Nicole Chi­ef­fo

→ It’s been a steady stream of new hires and pro­mo­tions at South San Fran­cis­co-based Sutro Bio­phar­ma, and this week is no dif­fer­ent with the in­tro­duc­tions of Nicole Chi­ef­fo (VP of clin­i­cal op­er­a­tions) and Wern­er Rubas (VP of pre­clin­i­cal de­vel­op­ment). Sutro poach­es Chi­ef­fo from Janssen, hold­ing such posts as se­nior di­rec­tor, on­col­o­gy glob­al op­er­a­tions head and lead on­col­o­gy clin­i­cal sci­en­tist. Rubas spent the last nine years at Nek­tar and was ex­ec­u­tive di­rec­tor in non-clin­i­cal phar­ma­co­ki­net­ics and phar­ma­co­dy­nam­ics. Along with Trevor Hal­lam’s pro­mo­tion to pres­i­dent of re­search and CSO, Sutro’s oth­er lead­er­ship moves in 2021 in­clude ap­point­ing CCO Jane Chung, pro­mot­ing David Paul­ing to gen­er­al coun­sel and el­e­vat­ing Robert Kiss to SVP of process and an­a­lyt­i­cal de­vel­op­ment.

jCyte just keeps on grow­ing too — its lat­est new­com­er is Vic­tor Chao as the Cal­i­for­nia biotech’s first VP of CMC op­er­a­tions, ap­point­ed late last week. Chao ar­rived at jCyte af­ter leav­ing San­ten Phar­ma­ceu­ti­cals as its head of com­mer­cial op­er­a­tions in North and Latin Amer­i­ca. The new jCyte staffers un­der first-year CEO Shan­non Blalock run the gamut from CFO Adam Walsh to gen­er­al coun­sel John Shol­ar, among sev­er­al oth­ers.

Tim Largen

→ Af­ter adding Daniela Dra­go from Bio­gen as chief reg­u­la­to­ry of­fi­cer last month, Au­ri­on Biotech ap­points Tim Largen as VP of man­u­fac­tur­ing. Largen over­saw man­u­fac­tur­ing at Lykan Bio­science af­ter spend­ing near­ly a decade climb­ing the ranks at Den­dreon. Au­ri­on, which has head­quar­ters in the US and Japan, is fo­cused on push­ing for­ward its first can­di­date, a cell ther­a­py to treat corneal en­dothe­lial dys­func­tion.

Ae­tion, the New York health tech start­up that has for­mer FDA com­mis­sion­er Scott Got­tlieb sit­ting on its board of di­rec­tors, has named Mar­la Kessler its first chief cus­tomer of­fi­cer. Kessler comes to the com­pa­ny from IQVIA, where she served as SVP, strat­e­gy, mar­ket­ing and com­mu­ni­ca­tion. In ad­di­tion to her role at IQVIA, Kessler has served at Pfiz­er and McK­in­sey. Kessler cur­rent­ly sits on the board of Iron­wood Phar­ma­ceu­ti­cals.

Ra­tio­nal Vac­cines, fo­cused on the treat­ment and pre­ven­tion of her­pes, has wel­comed Ker­stin Westritschnig as CMO. Westritschnig hails from Ape­iron Bi­o­log­ics, where she al­so served in the role of CMO. Pri­or to that, she was SVP and mem­ber of the ex­ec­u­tive com­mit­tee of Val­ne­va.

Christi­na Isac­son

→ Run­ning in par­al­lel with the news of a third and largest ven­ture fund — $375 mil­lion, to be ex­act — Light­stone Ven­tures has al­so named Christi­na Isac­son as part­ner and Young Kwon as op­er­at­ing part­ner. The ex-Third Rock prin­ci­pal and in­ter­im head of busi­ness de­vel­op­ment and strat­e­gy at Deci­bel, Isac­son had been CBO at Ma­gen­ta Ther­a­peu­tics un­til this March. Kwon spent a decade with Mo­men­ta, ini­tial­ly as VP of busi­ness de­vel­op­ment and then work­ing his way up to chief fi­nan­cial and busi­ness of­fi­cer.

→ Lon­don-based VC Abing­worth has named Jay Cui and Lu­cille Con­roy prin­ci­pals, while Diya Mal­ho­tra jumps ship from LEK Con­sult­ing to be an in­vest­ment man­ag­er. Cui was most re­cent­ly a di­rec­tor at Ab­b­Vie Ven­tures, while Con­roy was a se­nior as­so­ciate at F-Prime Cap­i­tal af­ter al­most two years at McK­in­sey.

Kathy Biber­stein

→ Churn­ing out biotechs at its usu­al steady clip, Flag­ship Pi­o­neer­ing has brought on Kathy Biber­stein as gen­er­al coun­sel and will of­fi­cial­ly join the team on Mon­day. In 2018 Biber­stein wrapped up a 15-year as­so­ci­a­tion with Alk­er­mes in which she wore a num­ber of ex­ec­u­tive hats — EVP, chief ad­min­is­tra­tive of­fi­cer, chief com­pli­ance of­fi­cer, chief risk of­fi­cer, and chief le­gal of­fi­cer. She’s al­so left the board of Nes­san Berming­ham-chaired Triplet Ther­a­peu­tics af­ter on­ly serv­ing less than a year in that ca­pac­i­ty.

Eliz­a­beth Bekiroğlu

→ No yel­low cards for Icosavax as the Seat­tle-based vac­cine biotech push­es for­ward with Neil King’s VLP “soc­cer ball” tech­nol­o­gy — and Eliz­a­beth Bekiroğlu in­tends to keep it that way as gen­er­al coun­sel. Bekiroğlu stays in Seat­tle af­ter be­ing Seagen’s as­so­ciate gen­er­al coun­sel, and once up­on a time she was gen­er­al coun­sel at Emer­gent BioSo­lu­tions. Icosavax end­ed up rais­ing $182 mil­lion in an up­sized IPO this sum­mer.

Hex­Trans­for­ma has reeled in Kevin Mor­ris as chief tech­nol­o­gy of­fi­cer. Mor­ris pre­vi­ous­ly served as VP of en­gi­neer­ing at Me­di­da­ta So­lu­tions. Mor­ris al­so brings with him ex­pe­ri­ence from his roles at Rovi Eu­rope (now Ti­Vo), Macro­vi­sion and Shal­bourne Tech­nol­o­gy.

→ Neu­rode­gen­er­a­tive dis­ease-fo­cused Alzheon has brought on two new hires with the ap­point­ments of Adem Al­bayrak as head of op­er­a­tions and Earvin Liang as VP of clin­i­cal de­vel­op­ment. Al­bayrak comes from Health Cat­a­lyst’s life sci­ences busi­ness, where he served as SVP for tech­nol­o­gy. Ear­li­er in his ca­reer, Al­bayrak worked at Knome and the Dana-Far­ber Can­cer In­sti­tute.

Mean­while, Liang brings with him ex­pe­ri­ence from his time at Elan Phar­ma­ceu­ti­cals, Janssen, Alzheimer’s Im­munother­a­py and Tran­si­tion Ther­a­peu­tics.

Bri­an Di Do­na­to

Jim Wil­son‘s new start­up iECURE, which came from his work with Tachi Ya­ma­da, has reeled in Bri­an Di Do­na­to to its board of di­rec­tors. Di Do­na­to is cur­rent­ly CFO and head of strat­e­gy at Im­muno­core. Pri­or to his work with Im­muno­core, Di Do­na­to was SVP and CFO at Achillion.

Don Nichol­son

→ Ex-Nim­bus CEO Don Nichol­son has been elect­ed in­de­pen­dent chair­man of the board at Dan­ish-Bel­gian neu­rode­gen­er­a­tive dis­ease biotech Mu­na Ther­a­peu­tics. Nichol­son, who’s on the boards of Kymera and Gen­er­a­tion Bio, al­so chairs Disc Med­i­cine, Jnana Ther­a­peu­tics and NodThera.

→ ROME if you want to: Up­on the news of the Se­ries B fi­nanc­ing at Rosana Kapeller’s ROME Ther­a­peu­tics, Steven Kaf­ka and Jim Tren­kle have tak­en seats on the board of di­rec­tors. Kaf­ka is man­ag­ing part­ner at Sec­tion 32 and Tren­kle leads in­vest­ments at Sanofi Ven­tures, two VCs that fac­tored heav­i­ly in­to the $77 mil­lion round.

Deb­o­rah Dun­sire

Deb­o­rah Dun­sire has been ap­point­ed to the board of di­rec­tors at Sy­ros, which is pre­sent­ing Phase I da­ta for its can­cer drug SY-5609 at ES­MO. For­mer­ly a board mem­ber at Alex­ion and Al­ler­gan, Dun­sire has helmed Lund­beck since 2018 and is on the board of di­rec­tors at Ul­tragenyx.

John John­son

Chris­t­ian Itin’s crew at CAR-T out­fit Au­to­lus has named long­time biotech ex­ec John John­son chair­man of the board. The Big Phar­ma vet chaired the board at Strong­bridge Bio­phar­ma un­til he took over as CEO in Ju­ly 2020, but John­son has re­tained his board seat af­ter Garheng Kong suc­ceed­ed him as chair­man.

→ Gaithers­burg, MD-based Adap­tive Phage Ther­a­peu­tics, which scored a Se­ries B that ex­ceed­ed $40 mil­lion in May, has ap­point­ed George­town pro­fes­sor Jesse Good­man to the board of di­rec­tors. From 2009-14, Good­man was chief sci­en­tist at the FDA, and for three years with­in that pe­ri­od he took on the role of deputy com­mis­sion­er for sci­ence and pub­lic health.

Ruth Williams-Brink­ley

→ Two days be­fore reach­ing a li­cens­ing deal with Vi­for Phar­ma, for­mer Mar­tin Shkre­li com­pa­ny Tra­vere Ther­a­peu­tics added Ruth Williams-Brink­ley to its board of di­rec­tors. Williams-Brink­ley over­sees Kaiser Per­ma­nente’s op­er­a­tions in DC and sur­round­ing ar­eas, and was the CEO for mul­ti­ple hos­pi­tal sys­tems in her ca­reer.

→ Ex-Kymab CEO Si­mon Sturge’s next en­deav­or will be as ex­ec­u­tive chair­man of fi­bro­sis biotech Me­di­ar Ther­a­peu­tics out of Cam­bridge, MA. Sturge helmed Kymab un­til it was sold for close to $1.5 bil­lion in one of sev­er­al M&A deals Paul Hud­son has made at Sanofi this year.

Jen­nifer Her­ron

→ ADC Ther­a­peu­tics SVP and chief com­mer­cial of­fi­cer Jen­nifer Her­ron has joined the board of di­rec­tors at Chip Clark-led can­cer biotech Geno­cea Bio­sciences. The 10-year Bris­tol My­ers vet has al­so been CCO at Im­muno­Gen and Ari­ad Phar­ma­ceu­ti­cals.

→ Gilead and Pfiz­er vet Roger Mills has made his way to the board of di­rec­tors at Philadel­phia-based En­terin. Mills was EVP of de­vel­op­ment and then CMO at Aca­dia Phar­ma­ceu­ti­cals af­ter his tenure as Pfiz­er’s VP of glob­al R&D.

Ji­gar Raythatha

Ji­gar Raythatha be­comes a mem­ber of the board of di­rec­tors at Jounce Ther­a­peu­tics as Third Rock part­ner Cary Pf­ef­fer re­signs from the board on Dec. 31. Raythatha helmed Con­stel­la­tion Phar­ma­ceu­ti­cals from 2017 un­til its $1.7 bil­lion sale to Mor­phoSys, which was an­nounced in June.

Owl­stone Med­ical has ap­point­ed Mark Capone to its board of di­rec­tors as an in­de­pen­dent non-ex­ec­u­tive di­rec­tor. Capone is the for­mer pres­i­dent and CEO of Myr­i­ad Ge­net­ics and pre­vi­ous­ly held a 17-year stint at Eli Lil­ly.

Ruth McK­er­nan

Cu­mu­lus Neu­ro­science’s own founder and di­rec­tor, Ruth McK­er­nan, will be adding on the role of chair to her du­ties. McK­er­nan, who is a neu­ro­sci­en­tist, is al­so a ven­ture part­ner at the De­men­tia Dis­cov­ery Fund. Ad­di­tion­al­ly, McK­er­nan has pre­vi­ous­ly served as SVP at Pfiz­er and head of the Mer­ck Neu­ro­science Re­search Cen­tre.

→ Fun­gal dis­ease-fo­cused F2G has added Camil­la Soen­der­by to its board of di­rec­tors. Soen­der­by most re­cent­ly served as chief pa­tient val­ue & prod­uct strat­e­gy of­fi­cer at Take­da af­ter its ac­qui­si­tion of Shire. Pri­or to that, Soen­der­by was SVP, head of glob­al prod­uct strat­e­gy for Shire, and held roles at Roche, Ab­bott (now Ab­b­Vie) and Scher­ing-Plough.

Phase­Bio Phar­ma­ceu­ti­cals has brought on William Humphries to its board of di­rec­tors. Humphries is cur­rent­ly the CEO of Isosce­les Phar­ma­ceu­ti­cals and pre­vi­ous­ly served at Or­tho Der­ma­to­log­ics, the North Amer­i­can busi­ness of Merz and Stiefel Lab­o­ra­to­ries.

In ad­di­tion, an­oth­er di­rec­tor at Phase­Bio, Justin Klein, is step­ping down.

Snap­drag­on Chem­istry has ap­point­ed Don­na Black­mond to its sci­en­tif­ic ad­vi­so­ry board. Black­mond, a chem­i­cal en­gi­neer­ing pro­fes­sor, is cur­rent­ly the John C. Mar­tin en­dowed chair in chem­istry at the Scripps Re­search In­sti­tute.

Paul Schloess­er al­so con­tributed to this edi­tion.

Op­ti­miz­ing Cell and Gene Ther­a­py De­vel­op­ment and Pro­duc­tion: How Tech­nol­o­gy Providers Like Corn­ing Life Sci­ences are Spurring In­no­va­tion

Remarkable advances in cell and gene therapy over the last decade offer unprecedented therapeutic promise and bring new hope for many patients facing diseases once thought incurable. However, for cell and gene therapies to reach their full potential, researchers, manufacturers, life science companies, and academics will need to work together to solve the significant challenges facing the industry.

David Baker working with a student on their protein design (Jason Mast)

Sci­en­tists are fi­nal­ly learn­ing how to de­sign pro­teins from scratch. Drug de­vel­op­ment may nev­er be the same

SEATTLE — It’s a cloudy Thursday afternoon in mid-July and David Baker is reclining into the futon in his corner office at the University of Washington, arms splayed out like a daytime talk show host as he coaches another one of his postdocs through the slings and arrows of scientific celebrity.

“Be jealous of your time,” he says, before plotting ways of sneaking her out of Zooms. “It’s this horrible cost to science that you’re tied up in some stupid meeting.”

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Pre­sent­ing a live End­points News event: Man­ag­ing a biotech in tur­bu­lent times

Biotech is one of the smartest, best educated industries on the planet. PhDs abound. We’ve had a long enough track record to see a new generation of savvy, experienced execs coming together to run startups.

And in these times, they are being tested as never before.

Biotech is going through quite a rough patch right now. For 2 years, practically anyone with a decent resume and some half-baked ideas on biotech could start a company and get it funded. The pandemic made it easy in many ways to pull off an IPO, with traditional road shows shut down in exchange for a series of quick Zoom meetings. Generalist investors flocked as the numbers raised soared into the stratosphere.

Patty Murray, D-WA (Graeme Sloan/Sipa USA)(Sipa via AP Images)

Sen­ate user fee reau­tho­riza­tion bill omits ac­cel­er­at­ed ap­proval re­forms, shows wide gaps with House ver­sion

The Senate health committee on Tuesday released its first version of the bill to reauthorize all the different FDA user fees. But unlike the House version, there are only a few controversial items in the Senate’s version, which does not address either accelerated approval reforms or clinical trial diversity (as the House did).

While it’s still relatively early in the process of finalizing this legislation (the ultimate statutory deadline is the end of September), the House and Senate, at least initially, appear to be starting off in different corners on what should be included.

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Warren Buffett, Berkshire Hathaway CEO

Berk­shire Hath­away pulls out of Ab­b­Vie, Bris­tol My­ers Squibb in­vest­ments

It looks like Warren Buffett is sticking to ice cream and railroads for the moment.

The billionaire CEO of Berkshire Hathaway backed out of two major holdings in the pharma industry, Forexlive first reported, including a $410 million investment in AbbVie and a $324.4 million stake in Bristol Myers Squibb.

The move comes after Berkshire abandoned its Teva shares just last quarter, Bloomberg reported.

Long-ex­pect­ed UK lay­offs im­mi­nent for No­var­tis fol­low­ing sale

Nearly a year ago, more than 200 workers at Novartis’ Grimsby, UK, facility were able to hang on to their jobs after the pharma closed a Switzerland site as a part of its workforce restructuring plan. Now, it looks like those employees’ time is up, as the site has been sold, Grimsby Telegraph reported today.

The manufacturing site has been sold to Humber Industrials, a subsidiary of International Process Plants. None of the current staff members will be working with the new owners, however.

Clay Siegall (Photo by Dimitrios Kambouris/Getty Images for Gabrielle's Angel Foundation)

UP­DAT­ED: Clay Sie­gall re­signs from Seagen amid in­ves­ti­ga­tion in­to do­mes­tic vi­o­lence claims

A week after Seagen revealed that longtime CEO Clay Siegall was on leave due to an allegation of domestic violence, he has resigned.

Since that shocking revelation, more details about the claims have emerged into the public eye. As Endpoints News reported, Siegall was arrested on April 23. A police report about that night and a subsequent temporary restraining order described a pattern of abusive behavior against his wife and a physical altercation that left her with multiple bruises. Siegall denied the claims.

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FDA lob­bies Con­gress over rare dis­ease court rul­ing with wide im­pli­ca­tions

Usually reserved for making decisions on drug applications or enforcing what Congress stipulates, the FDA is now dipping its toe into the wild world of congressional politics as it attempts to fix a major court decision that could have a chilling effect on rare disease R&D.

The case in question from last October saw a US appeals court overturn a prior FDA court win, saying that the agency never should’ve approved a rare disease drug because a previously approved but more expensive drug with the same active ingredient has orphan drug exclusivity barring such an approval.

Peter Marks (Greg Nash/Pool via AP)

Even FDA's Pe­ter Marks is wor­ried about the com­mer­cial vi­a­bil­i­ty of gene and cell ther­a­pies

When bluebird bio’s gene therapy to treat beta thalassemia won European approval in 2019, the nearly $2 million per patient price tag for the potential cure seemed like a surmountable hurdle.

Fast forward two years later, and bluebird has withdrawn Zynteglo, the beta thal drug, along with the rest of its gene therapy portfolio from Europe, which the company said is generally unwilling to pay a fair price for the treatment.