Michael Milone and Saba Ghassemi (Penn)

A team at Penn says it has slashed CAR-T cell ther­a­py man­u­fac­tur­ing time­frame to just 24 hours

The fu­ture of CAR-T cell ther­a­py re­search has come a long way over the years, but sci­en­tists have still been plagued by one prob­lem: how to cut down on the time­frame, which typ­i­cal­ly takes be­tween 9 and 14 days.

Ex­cept now. Re­searchers at Penn say that they have short­ened the process, en­hanc­ing an­ti-tu­mor po­ten­cy in just 24 hours. The pre­clin­i­cal study, car­ried out by re­searchers Michael Milone and Sa­ba Ghas­se­mi, has been pub­lished in Na­ture Bio­med­ical En­gi­neer­ing. The re­sults show the po­ten­tial for a stark re­duc­tion of time, ma­te­ri­als and la­bor that’s re­quired to make CAR-T cells, which could be the most ben­e­fi­cial for those who are ex­pe­ri­enc­ing rapid­ly-pro­gress­ing dis­ease in en­vi­ron­ments with lim­it­ed re­sources.

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