Laurie Glimcher, Dana-Farber president and CEO (Franck Fife/AFP via Getty Images)

Dana-Far­ber CEO Lau­rie Glim­ch­er re­signs from GSK board — is she the next NIH di­rec­tor nom­i­nee?

GSK an­nounced this morn­ing in a Lon­don Stock Ex­change fil­ing that Lau­rie Glim­ch­er, pres­i­dent and CEO of the Dana-Far­ber Can­cer In­sti­tute, has ad­vised the com­pa­ny of her in­ten­tion to re­tire from its board of di­rec­tors on Oct. 13.

The com­pa­ny did not dis­close why Glim­ch­er has de­cid­ed to move on now af­ter more than five years as a non-ex­ec­u­tive di­rec­tor, but Glim­ch­er’s ap­point­ment her­ald­ed a much big­ger in­ter­est in on­col­o­gy at GSK, and she’s mov­ing on now as GSK’s R&D chief Hal Bar­ron al­so hits the ex­it.

A pi­o­neer­ing sci­en­tist and a cham­pi­on for ad­vanc­ing women to se­nior po­si­tions in the bio­med­ical world, Glim­ch­er took on the role at GSK af­ter de­part­ing from her role on the board of Bris­tol My­ers Squibb for two decades, where her im­muno-on­col­o­gy ex­per­tise proved valu­able.

So what’s next for Glim­ch­er? Dana-Far­ber told End­points in an emailed state­ment that she will con­tin­ue her lead­er­ship of Dana-Far­ber Can­cer In­sti­tute.

“I’m very proud of my ser­vice on the GSK Board as an ad­vo­cate for pa­tients with can­cer and ad­vanced can­cer re­search,” said Glim­ch­er. “I re­main fo­cused on re­duc­ing the bur­den of can­cer here and around the world. This means en­sur­ing ex­pert, com­pas­sion­ate, and eq­ui­table care for all pa­tients and ad­vanc­ing new treat­ments and cures.”

She said she will al­so con­tin­ue serv­ing on the board of di­rec­tors for Ana­log De­vices, a Wilm­ing­ton-based high per­for­mance de­vice mak­er, which she would al­so like­ly have to drop if NIH comes call­ing.

Her name has been float­ed in in­ner NIH and FDA cir­cles to lead both those agen­cies. While she pre­vi­ous­ly told End­points News she was not a can­di­date to be the next com­mis­sion­er of the FDA (pri­or to Rob Califf’s con­fir­ma­tion), she’s been an ad­vo­cate for boost­ing NIH re­sources over the years.

In her post­doc days, she did a three-year stint at Bill Paul’s lab­o­ra­to­ry at NIH, where Paul was the leader of the NIH im­munol­o­gy com­mu­ni­ty. She al­so penned an op-ed a few years ago about how the NIH is in dan­ger of los­ing its edge in bio­med­ical in­no­va­tion.

Her re­search and ex­ec­u­tive ex­pe­ri­ence would make her a top choice for the NIH, es­pe­cial­ly as for­mer NIH di­rec­tor Fran­cis Collins re­tired but then had to re­turn to help out when Pres­i­dent Biden’s sci­en­tif­ic lead­er­ship was in flux af­ter the White House’s top sci­en­tist Er­ic Lan­der re­signed af­ter de­mean­ing women in his of­fice.

While some might say that Biden’s sci­en­tif­ic lead­er­ship is still in flux, the re­cent ad­di­tions of Califf at FDA, Ashish Jha as the White House coro­n­avirus re­sponse co­or­di­na­tor, and the ex­pect­ed nom­i­na­tion of Mon­i­ca Bertag­nol­li, an em­i­nent sur­gi­cal on­col­o­gist and physi­cian-sci­en­tist at the Na­tion­al Can­cer In­sti­tute, could pave the way for a new gov­ern­ment role for Glim­ch­er.

Ed­i­tor’s note: Ar­ti­cle up­dat­ed with com­ment from Glim­ch­er and Dana-Far­ber.

Forge Bi­o­log­ics’ cGMP Com­pli­ant and Com­mer­cial­ly Vi­able Be­spoke Affin­i­ty Chro­matog­ra­phy Plat­form

Forge Biologics has developed a bespoke affinity chromatography platform approach that factors in unique vector combinations to streamline development timelines and assist our clients in efficiently entering the clinic. By leveraging our experience with natural and novel serotypes and transgene conformations, we are able to accelerate affinity chromatography development by nearly 3-fold. Many downstream purification models are serotype-dependent, demanding unique and time-consuming development strategies for each AAV gene therapy product1. With the increasing demand to propel AAV gene therapies to market, platform purification methods that support commercial-scale manufacturing of high-quality vectors with excellent safety and efficacy profiles are essential.

Mathai Mammen, FogPharma's next CEO

Math­ai Mam­men hands in J&J's R&D keys to lead Greg Ver­dine’s Fog­Phar­ma 

In the early 1990s, Mathai Mammen was a teaching assistant in Greg Verdine’s Science B46 course at Harvard. In June, the former R&D head at Johnson & Johnson will succeed Verdine as CEO, president and chair of FogPharma, the same month the seven-year-old biotech kickstarts its first clinical trial.

After leading R&D at one of the largest drugmakers in the world, taking the company through more than half a dozen drug approvals in the past few years, not to mention a Covid-19 vaccine race, Mammen departed J&J last month and will take the helm of a Cambridge, MA biotech attempting to go after what Verdine calls the “true emperor of all oncogenes” — beta-catenin.

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Cy­to­ki­net­ics’ ALS drug fails PhI­II, leav­ing the biotech with a sin­gle late-stage prospect

Cytokinetics’ candidate for the muscle disease amyotrophic lateral sclerosis, or ALS, failed a Phase III trial, the Bay Area biotech announced Friday morning.

At a second interim analysis of the trial, an independent review committee recommended that Cytokinetics discontinue its COURAGE-ALS trial for reldesemtiv, as it “found no evidence of effect” compared to placebo on the primary or key secondary endpoints.

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TScan Therapeutics' departing CEO David Southwell and CSO/COO Gavin MacBeath

TCR up­start an­nounces CEO ex­it, with CSO now act­ing re­place­ment

A public T cell biotech’s chief executive has decided to leave the company.

TScan Therapeutics said Friday morning that CEO David Southwell stepped down earlier this week, leaving both his chief executive and board member roles. Filling in is Gavin MacBeath, the company’s CSO and COO. He became the acting CEO on Tuesday, and will continue to remain CSO and COO, TScan’s announcement read.

Sen­ate Fi­nance Com­mit­tee lobs more bi­par­ti­san pres­sure on­to PBMs

Congress is honing in on how it wants to overhaul the rules of the road for pharmacy benefit managers, with a Senate Finance Committee hearing Thursday serving as the latest example of the Hill’s readiness to make changes to how pharma middlemen operate.

While pledging to ensure patients and pharmacies “don’t get a raw deal,” Finance Committee Chair Ron Wyden (D-OR) laid out the beginning of what looks like a major bipartisan effort — moves the PBM industry is likely to challenge vigorously.

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Nicklas Westerholm, Egetis Therapeutics CEO

Ac­qui­si­tion talks on­go­ing for Swedish rare dis­ease biotech Egetis, shares up al­most 40%

Shares of the Sweden-based rare disease biotech Egetis Therapeutics skyrocketed on Thursday afternoon as the company said it’s engaged in “ongoing discussion” with external parties regarding a “potential acquisition.”

Egetis confirmed rumors with a statement on Thursday while noting that there is no certainty that a takeover offer will be made.

Nonetheless, the possibility of an acquisition has shot up Egetis’ share price. By the afternoon on Thursday, its stock price was {$EGTX.ST} up over 38%. An Egetis spokesperson told Endpoints News in an email that it has no further comments.

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Lu­pus drug de­vel­op­ment mar­ket heat­ing up, while FDA links with ad­vo­ca­cy group to fur­ther ac­cel­er­ate re­search

The long-underserved systemic lupus erythematosus (SLE) market is suddenly buzzing with treatment possibilities. Less than two years after AstraZeneca’s approval for Saphnelo — the first new SLE drug in a decade and joining just one other approved in GSK’s Benlysta – the pipeline of potential drugs numbers in the dozens.

Although most are very early stage — Spherix Global Insights estimates five in Phase II/III — the pharma R&D enthusiasm is catching on among doctors, patients and advocacy groups. On Wednesday, the Lupus Research Alliance and the FDA formed a novel private-public partnership called Lupus Accelerating Breakthroughs Consortium (Lupus ABC) to help advance lupus clinical trial success.

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Austin biotech Mol­e­c­u­lar Tem­plates lays off more than 100 staffers as pipeline nar­rows

Molecular Templates is ridding itself of a Phase I HER2 asset and fine-tuning its pipeline to focus on three programs and a preclinical Bristol Myers Squibb collaboration. With the narrowed scope on its so-called engineered toxin bodies, the Austin, TX biotech is laying off about half of its staff.

That’s a little more than 100 employees, per an SEC filing. Molecular’s layoffs, approved by its board Wednesday, add to the dozens of pullbacks in the industry in the first three months of 2023.

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Aptinyx eval­u­ates fu­ture of the com­pa­ny fol­low­ing two failed tri­als, 60% lay­offs

This year has been tough for Aptinyx — two failed trials, a 60% cut in its workforce, and now the company has brought on a firm to help evaluate the future of the company.

The press release noted it’s working with the firm Ladenburg Thalmann as its financial advisor to assist in exploring and evaluating “strategic alternatives” — a process that a growing group of struggling biotechs has embarked on, sometimes ending in a merger, asset sale or wind-down.

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