Dyno sketch­es tens of thou­sands of vi­able next-gen AAV cap­sids with the help of ma­chine learn­ing — pa­per

Since its launch in May 2020, Dyno Ther­a­peu­tics has tout­ed its plat­form’s po­ten­tial to dis­cov­er vi­able vari­a­tions of cur­rent-gen AAVs with no­tice­able lim­i­ta­tions in terms of pa­tient safe­ty and ef­fi­ca­cy. Now, ac­cord­ing to a new study, Dyno has used its neur­al net­work to out­line tens of thou­sands of vari­ants that could add weight to its mis­sion to build a bet­ter cap­sid.

In a study meant to de­ter­mine how many vi­able vari­ants of the AAV2 cap­sid it could de­sign with the aid of ma­chine learn­ing, Dyno sketched out more than 100,000 virus­es that could be used to car­ry gene ther­a­pies, ac­cord­ing to a new pa­per pub­lished in Na­ture Biotech­nol­o­gy.

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