J&J joins block­buster HIV com­bo race with new­ly ap­proved 4-in-1 pill

Slid­ing in­to the HIV com­bo ri­val­ry be­tween Gilead and GSK, J&J has notched an ap­proval for a 4-in-1 pill based on its an­ti­retro­vi­ral med darunavir.

To be mar­ket­ed as Sym­tuza, the drug is a sin­gle dai­ly pill that com­bines J&J’s darunavir (800mg) with co­bici­s­tat (150 mg), emtric­itabine (200 mg) and teno­fovir alafe­namide (10 mg) from Gilead. The lat­ter two form the back­bone com­bi­na­tion for Gilead’s block­buster triplet Bik­tarvy — with 2022 pro­ject­ed sales at $3.71 bil­lion — while co­bici­s­tat is a phar­ma­co­ki­net­ic en­hancer.

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