New cardio target ANGPTL3 with promising new studies; Liverpool says Redx is delinquent; Aslan's $33M Taipei IPO
→ Regeneron and Ionis each have publications in The New England Journal of Medicine aimed at a brand new cardio target ANGPTL3. The New York Times chronicles the story, which begins in 1994 when a woman in St. Louis gave a blood sample at an employer-sponsored health fair. Regeneron is working on a monoclonal antibody which they say has reduced atherosclerotic lesions in mice and lowered triglycerides and LDL in humans. Ionis is going after the same target using an antisense oligonucleotide targeting Angptl3 messenger RNA. They say they observed dose-dependent reductions in triglycerides and LDL, slowing of atherosclerosis progression and an increase in insulin sensitivity in mice that received the compound. Human participants who received weekly injections of the oligonucleotide had triglyceride reductions ranging from 33% to 63%, LDL reductions ranging from 1% to 33%, VLDL reductions of 28%-60%, and non-HDL level reductions of 10% to 36.6%.
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