Pfizer/Merck KGaA launch solid tumor combo study with Leap; AstraZeneca and Immunomedics to test ADC cancer combo
→ Pfizer and Merck KGaA are teaming up with Leap Therapeutics $LPTX to evaluate the small Cambridge, MA-based company’s drug in a combo with Bavencio (avelumab) and chemo. Leap is developing a drug called TRX518, a humanized monoclonal antibody that binds to the glucocorticoid-inducible TNF-superfamily receptor. It’s believed to boost the body’s anti-tumor response, and will be tested in this combo in patients with solid tumors. Under the terms of the deal, Leap will conduct a Phase I/II study, with enrollment starting in Q1 2019.
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