Results, Setbacks

Roche pulls another major piece out of the wobbly Alzheimer’s jenga, shuttering crenezumab PhIIIs

When AC Immune announced two years ago that its partners at Genentech is launching a second Phase III for its Alzheimer’s drug, CEO Andrew Pfeifer touted crenezumab as a “distinct” hope amid disappointing results of other anti-amyloid beta therapies, given at higher doses and targeting earlier stages of the disease.

Today crenezumab has become a big disappointment itself — marking another prominent failure in a frustration-prone field.


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Wren Therapeutics Boston, MA
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Northpond Ventures Washington, DC
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Schrödinger New York, NY

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