Geoffrey Porges, SVB Leerink

Top an­a­lyst maps a rocky road for Ver­tex — un­less they adopt a $10B M&A cam­paign to save the pipeline

Af­ter re­peat­ed­ly pok­ing Ver­tex $VRTX ex­ecs with point­ed crit­i­cism of their R&D strat­e­gy, top SVB Leerink an­a­lyst Ge­of­frey Porges is now turn­ing up the heat to a full-scale roast­ing.

In a note out ear­ly Mon­day morn­ing, Porges spot­lights the im­pact of Ver­tex’s re­cent fol­low-up fail­ure on AATD — their treat­ment hit the end­point but missed on com­mer­cial prospects — rewrit­ing his rec­om­mend­ed sce­nario for CEO Resh­ma Ke­wal­ra­mani as she grap­ples with the set­back.

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