Drug Development

Two flops in two weeks for Marinus Pharmaceuticals’ ganaxolone 

Days after Marinus Pharmaceutical’s ganaxolone failed on an epilepsy study, the same drug failed a Fragile X syndrome trial, further bruising the biotech’s already badly damaged market value.

Rather incredibly, the biotech ($MRNS) claims it didn’t expect to hit the primary endpoint: overall improvement across the Fragile X syndrome. Instead the biotech hailed data on ganaxolone’s effectiveness in treating anxiety for patients and intends to use that to find some path forward for the GABAA modulator.

Christopher Cashman, CEO

Christopher Cashman, CEO of Marinus

“Our goal for this study was to measure improvement in these behaviors based upon the anxiolytic activity of ganaxolone and use the results from this exploratory study to inform enrollment criteria and endpoint selection in future studies. The data we observed in several analyses related to patient anxiety and attention are encouraging and clearly warrant further investigation,” offered Marinus CEO Christopher Cashman in a prepared statement.

Its shares are down under $2.00 this morning on the news. The company traded as high as $17.00 this time last year.

Get Endpoints News in your inbox

Newsletters for those who discover, develop, and market drugs. Enjoy the news with the story intact — entire articles in your inbox, no clicks required. Join 12,000+ biopharma pros who read Endpoints News every day. Free subscription.


Subscribe to Endpoints

John Carroll, Editor and Co-Founder

We produce two daily newsletters designed to give you a complete picture of what's important in biopharma.

Early Edition is a skimmable digest of original sources you need to see by ~7:15a ET, and our Main Edition is the daily chronicle of biotech, with every story inside the email ~11:55a ET.
2x/weekdays. Privacy policy