Ar­a­vive merges with strug­gling Ver­sar­tis, gain­ing ac­cess to Nas­daq; Si­lence Ther­a­peu­tics CEO Ali Mor­taza­vi leaves the RNAi biotech

→ Right on the heels of its first clin­i­cal proof-of-mech­a­nism da­ta, Ar­a­vive Bi­o­log­ics an­nounced it will con­tin­ue the de­vel­op­ment of GAS6-AXL in­hibitor AVB-S6-500 as a pub­lic com­pa­ny formed through merg­ing with a Ver­sar­tis $VSAR sub­sidiary. Jay Shep­ard, CEO of Men­lo Park, CA-based Ver­sar­tis, will take the helm of the new com­pa­ny, which will have its head­quar­ters in Ar­a­vive’s home of Hous­ton. The deal fills a gap­ing hole in Ver­sar­tis’ pipeline, which has been bar­ren since its growth hor­mone flopped in a Phase III last Sep­tem­ber, and piv­ots its fo­cus from en­docrinol­o­gy to on­col­o­gy. Ar­a­vive, on the oth­er hand, is in for the “fi­nan­cial re­sources and ex­pe­ri­enced lead­er­ship.” “Ver­sar­tis’ de­vel­op­ment and com­mer­cial plan­ning ex­per­tise, as well as its op­er­a­tional pro­fi­cien­cy, will com­ple­ment the strong sci­en­tif­ic and clin­i­cal ca­pa­bil­i­ties of the Ar­a­vive team,” said Ar­a­vive ex­ec­u­tive chair­man Ray Tabib­i­azar, who is one of sev­en board di­rec­tors of the new biotech.

Ali Mor­taza­vi

Si­lence Ther­a­peu­tics is part­ing ways with CEO Ali Mor­taza­vi af­ter six years and putting now ex­ec­u­tive chair An­nal­isa Jenk­ins in charge while it search­es for a per­ma­nent chief. Though found­ed in 1994, the Lon­don-based biotech is still in pre­clin­i­cal phas­es as it went through some soul-search­ing in 2012 — when Mor­taza­vi joined the com­pa­ny — and de­cid­ed to fo­cus on RNA-based drugs. With his back­ground in fi­nance, Mor­taza­vi con­vinced in­vestors to back Si­lence’s tech plat­form, which promis­es to in­hib­it (or “si­lence”) the ex­pres­sion of dis­ease-caus­ing genes through RNA in­ter­fer­ence. Its pipeline now spans hema­tol­ogy, meta­bol­ic dis­eases and oth­er dis­eases like al­co­hol use dis­or­der. “We be­lieve to­day that our RNAi plat­form and R&D ca­pa­bil­i­ties of­fer an op­por­tu­ni­ty to ad­vance our lead pro­gramme in iron me­tab­o­lism to­wards the clin­ic and to es­tab­lish re­search part­ner­ships that will max­imise share­hold­er val­ue. We wish Ali every suc­cess in his fu­ture en­deav­ours,” said Jenk­ins, who’s al­so CEO of liq­uid biop­sy com­pa­ny Pla­que­Tec.

→ Enyo Phar­ma is push­ing for­ward its hep B and NASH pro­grams with cash it just closed as part of a €40 mil­lion ($46.9 mil­lion) Se­ries B round an­nounced Mon­day. The Ly­on, France-based com­pa­ny is work­ing on lead project EYP001, a syn­thet­ic far­ne­soid X re­cep­tor (FXR) ag­o­nist the com­pa­ny hopes can cure chron­ic he­pati­tis B. It’s al­so be­ing ex­am­ined as a NASH drug. The new fund­ing, backed by Or­bimed as the lead, will take Enyo in­to Phase II tri­als for both in­di­ca­tions through 2018 and 2019, the com­pa­ny said in a state­ment.

Norbert Bischofberger. Kronos

Backed by some of the biggest names in biotech, Nor­bert Bischof­berg­er gets his megaround for plat­form tech out of MIT

A little over a year ago when I reported on Norbert Bischofberger’s jump from the CSO job at giant Gilead to a tiny upstart called Kronos, I noted that with his connections in biotech finance, that $18 million launch round he was starting off with could just as easily have been $100 million or more.

With his first anniversary now behind him, Bischofberger has that mega-round in the bank.

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Francesco De Rubertis

Medicxi is rolling out its biggest fund ever to back Eu­rope's top 'sci­en­tists with strange ideas'

Francesco De Rubertis built Medicxi to be the kind of biotech venture player he would have liked to have known back when he was a full time scientist.

“When I was a scientist 20 years ago I would have loved Medicxi,’ the co-founder tells me. It’s the kind of place run by and for investigators, what the Medicxi partner calls “scientists with strange ideas — a platform for the drug hunter and scientific entrepreneur. That’s what I wanted when I was a scientist.”

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Af­ter a decade, Vi­iV CSO John Pot­tage says it's time to step down — and he's hand­ing the job to long­time col­league Kim Smith

ViiV Healthcare has always been something unique in the global drug industry.

Owned by GlaxoSmithKline and Pfizer — with GSK in the lead as majority owner — it was created 10 years ago in a time of deep turmoil for the field as something independent of the pharma giants, but with access to lots of infrastructural support on demand. While R&D at the mother ship inside GSK was souring, a razor-focused ViiV provided a rare bright spot, challenging Gilead on a lucrative front in delivering new combinations that require fewer therapies with a more easily tolerated regimen.

They kept a massive number of people alive who would otherwise have been facing a death sentence. And they made money.

And throughout, John Pottage has been the chief scientific and chief medical officer.

Until now.

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Chas­ing Roche's ag­ing block­buster fran­chise, Am­gen/Al­ler­gan roll out Avastin, Her­ceptin knock­offs at dis­count

Let the long battle for biosimilars in the cancer space begin.

Amgen has launched its Avastin and Herceptin copycats — licensed from the predecessors of Allergan — almost two years after the FDA had stamped its approval on Mvasi (bevacizumab-awwb) and three months after the Kanjinti OK (trastuzumab-anns). While the biotech had been fielding biosimilars in Europe, this marks their first foray in the US — and the first oncology biosimilars in the country.

Seer adds ex-FDA chief Mark Mc­Clel­lan to the board; Her­cules Cap­i­tal makes it of­fi­cial for new CEO Scott Bluestein

→ On the same day it announced a $17.5 million Series C, life sciences and health data company Seer unveiled that it had lured former FDA commissioner and ex-CMS administrator Mark McClellan on to its board. “Mark’s deep understanding of the health care ecosystem and visionary insights on policy reform will be crucial in informing our thinking as we work to bring our liquid biopsy and life sciences products to market,” said Seer chief and founder Omid Farokhzad in a statement.

Daniel O'Day

No­var­tis hands off 3 pre­clin­i­cal pro­grams to the an­tivi­ral R&D mas­ters at Gilead

Gilead CEO Daniel O’Day’s new task hunting up a CSO for the company isn’t stopping the industry’s dominant antiviral player from doing pipeline deals.

The big biotech today snapped up 3 preclinical antiviral programs from pharma giant Novartis, with drugs promising to treat human rhinovirus, influenza and herpes viruses. We don’t know what the upfront is, but the back end has $291 million in milestones baked in.

Vas Narasimhan, AP Images

On a hot streak, No­var­tis ex­ecs run the odds on their two most im­por­tant PhI­II read­outs. Which is 0.01% more like­ly to suc­ceed?

Novartis CEO Vas Narasimhan is living in the sweet spot right now.

The numbers are running a bit better than expected, the pipeline — which he assembled as development chief — is performing and the stock popped more than 4% on Thursday as the executive team ran through their assessment of Q2 performance.

Year-to-date the stock is up 28%, so the investors will be beaming. Anyone looking for chinks in their armor — and there are plenty giving it a shot — right now focus on payer acceptance of their $2.1 million gene therapy Zolgensma, where it’s early days. And CAR-T continues to underperform, but Novartis doesn’t appear to be suffering from it.

So what could go wrong?

Actually, not much. But Tim Anderson at Wolfe pressed Narasimhan and his development chief John Tsai to pick which of two looming Phase III readouts with blockbuster implication had the better odds of success.

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On a glob­al romp, Boehringer BD team picks up its third R&D al­liance for Ju­ly — this time fo­cused on IPF with $50M up­front

Boehringer Ingelheim’s BD team is on a global deal spree. The German pharma company just wrapped its third deal in 3 weeks, going back to Korea for its latest pipeline pact — this time focused on idiopathic pulmonary fibrosis.

They’re handing over $50 million to get their hands on BBT-877, an ATX inhibitor from Korea’s Bridge Biotherapeutics that was on display at a science conference in Dallas recently. There’s not a whole lot of data to evaluate the prospects here.

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Servi­er scoots out of an­oth­er col­lab­o­ra­tion with Macro­Gen­ics, writ­ing off their $40M

Servier is walking out on a partnership with MacroGenics $MGNX — for the second time.

After the market closed on Wednesday MacroGenics put out word that Servier is severing a deal — inked close to 7 years ago — to collaborate on the development of flotetuzumab and other Dual-Affinity Re-Targeting (DART) drugs in its pipeline.

MacroGenics CEO Scott Koenig shrugged off the departure of Servier, which paid $20 million to kick off the alliance and $20 million to option flotetuzumab — putting a heavily back-ended $1 billion-plus in additional biobuck money on the table for the anti-CD123/CD3 bispecific and its companion therapies.